The effect of alpha lipoic acid on passive avoidance and social interaction memory, pain perception, and locomotor activity in REM sleep-deprived rats

Mahdavi, Mohadese Sadat; Nasehi, Mohammad; Vaseghi, Salar; Mousavi, Zahra; Zarrindast, Mohammad‐Reza

doi:10.1007/s43440-020-00161-8

Cited by 17 publications

(5 citation statements)

References 48 publications

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“…This apparatus consisted of clear perspex container box (height: 30 × 30 × 40 cm) divided into 16 equal-sized squares. Locomotor activity was evaluated as the number of crossings from one square to another during 300 s (Mahdavi et al, 2021; Rezaie et al, 2021). Furthermore, anxiety level was measured by recording the time spent in the four middle squares of the field (a preference to stay close to the walls of the field considered as anxiety; Ennaceur, 2014).…”

Section: Methodsmentioning

confidence: 99%

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Psilocybe cubensis extract potently prevents fear memory recall and freezing behavior in short- but not long-term in a rat model of posttraumatic stress disorder.

Ghofrani-Jahromi,

Nouri-Darehno,

Rahimi-Danesh

et al. 2024

Behavioral Neuroscience

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Psilocybe cubensis is a species of psilocybin mushroom (magic mushroom) of moderate potency whose principal active compounds are psilocybin and psilocin. Recent studies have shown the significant procognitive and mood-enhancer effects of Psilocybe cubensis. However, evidence is so limited, especially in preclinical studies. We aimed to investigate the effect of Psilocybe cubensis extract on posttraumatic stress disorder (PTSD)-like behavior, pain perception, locomotor activity, and anxiety in a rat model of PTSD. Male rats were exposed to three consecutive shocks (0.8 mA, 3 s interval) paired with three sounds broadcasted 3 s before delivering shocks (75 dB, 3 s). After 1, 3, or 21 days, freezing rate was measured in the fear-conditioning apparatus. Open filed test and hot plate were used to assess locomotor activity and anxiety, and pain subthreshold, respectively. Psilocybe cubensis was injected intraperitoneal at the dose of 25 mg/kg (single administration) before (pretrain) or after (posttrain) shocks, or before the test (pretest). Results showed psilocybin potently alleviated PTSD symptom is short-but not long-term after the induction of PTSD. Psilocybe cubensis decreased locomotor activity only in a short period after administration. Psilocybe cubensis also increased pain subthreshold and decreased anxiety. In conclusion, Psilocybe cubensis effects on PTSD-like behavior and locomotor activity seem to be remained in short-term, while Psilocybe cubensis effects on pain subthreshold and anxiety remained long-term. This is the first study evaluating the effect of Psilocybe cubensis on PTSD-like behavior in rats in three different time protocols (1, 3, and 21 days after fear conditioning).

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Section: Methodsmentioning

confidence: 99%

“…The temperature of the apparatus was set at 50 °C. The cutoff time was 120 s (Mahdavi et al, 2021). The score was automatically recorded by the device, while the experimenter was blinded to groups.…”

Section: Hot Plate Apparatusmentioning

confidence: 99%

Psilocybe cubensis extract potently prevents fear memory recall and freezing behavior in short- but not long-term in a rat model of posttraumatic stress disorder.

Ghofrani-Jahromi,

Nouri-Darehno,

Rahimi-Danesh

et al. 2024

Behavioral Neuroscience

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“…OFT consisted of clear perspex container box (120 × 120 × 50 cm) with 16 equal-sized squares. The total traveled distance during 300s showed the level of locomotor activity (Mahdavi et al ., 2021; Rezaie et al ., 2021). In contrast, anxiety level was measured by recording the time spent in the four middle squares of the field (a preference to stay close to the walls of the field was considered as anxiety-like behavior) (Ennaceur, 2014).…”

Section: Methodsmentioning

confidence: 99%

“…The temperature of the apparatus was set at 50 °C and was stable during each test. The cutoff time was 100 s (Mahdavi et al ., 2021). The scores were automatically recorded by the device; however, the experimenter was also blinded to groups.…”

Section: Methodsmentioning

confidence: 99%

Crocin (bioactive compound of Crocus sativus L.) potently restores REM sleep deprivation-induced manic- and obsessive-compulsive-like behaviors in female rats

Houshyar,

Karimi,

Ghofrani-Jahromi

et al. 2024

Behavioural Pharmacology

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Rapid-eye movement (REM) sleep deprivation (SD) can induce manic-like behaviors including hyperlocomotion. On the other hand, crocin (one of the main compounds of Crocus sativus L. or Saffron) may be beneficial in the improvement of mental and cognitive dysfunctions. Also, crocin can restore the deleterious effects of SD on mental and cognitive processes. In this study, we investigated the effect of REM SD on female rats’ behaviors including depression- and anxiety-like behaviors, locomotion, pain perception, and obsessive-compulsive-like behavior, and also, the potential effect of crocin on REM SD effects. We used female rats because evidence on the role of REM SD in modulating psychological and behavioral functions of female (but not male) rats is limited. REM SD was induced for 14 days (6h/day), and crocin (25, 50, and 75 mg/kg) was injected intraperitoneally. Open field test, forced swim test, hot plate test, and marble burying test were used to assess rats’ behaviors. The results showed REM SD-induced manic-like behavior (hyperlocomotion). Also, REM SD rats showed decreased anxiety- and depression-like behavior, pain subthreshold (the duration it takes for the rat to feel pain), and showed obsessive compulsive-like behavior. However, crocin at all doses partially or fully reversed REM SD-induced behavioral changes. In conclusion, our results suggested the possible comorbidity of OCD and REM SD-induced manic-like behavior in female rats or the potential role of REM SD in the etiology of OCD, although more studies are needed. In contrast, crocin can be a possible therapeutic choice for decreasing manic-like behaviors.

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“…As we know, SD induces a wide-range of negative effects on cognitive functions (Rezaie et al, 2020[ 91 ][ 92 ]). Previous studies have shown that memory and mood state are highly affected following SD (Javad-Moosavi et al, 2020[ 45 ]; Kordestani-Moghadam et al, 2020[ 52 ]; Mahdavi et al, 2020[ 65 ]). But why do sleep restrictions dramatically disrupt many of the cognitive and physiological processes?…”

Section: Introductionmentioning

confidence: 99%

Inconsistent effects of sleep deprivation on memory function

Vaseghi

Arjmandi-Rad

Kholghi

et al. 2021

EXCLI Journal; 20:Doc1011; ISSN 1611-2156

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The effect of alpha lipoic acid on passive avoidance and social interaction memory, pain perception, and locomotor activity in REM sleep-deprived rats

Cited by 17 publications

References 48 publications

Psilocybe cubensis extract potently prevents fear memory recall and freezing behavior in short- but not long-term in a rat model of posttraumatic stress disorder.

Psilocybe cubensis extract potently prevents fear memory recall and freezing behavior in short- but not long-term in a rat model of posttraumatic stress disorder.

Crocin (bioactive compound of Crocus sativus L.) potently restores REM sleep deprivation-induced manic- and obsessive-compulsive-like behaviors in female rats

Inconsistent effects of sleep deprivation on memory function

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