The Effect of Artery Bifurcation Angles on Fluid Flow and Wall Shear Stress in the Middle Cerebral Artery

Jones, Zachary Ramey

doi:10.15368/theses.2014.168

Cited by 3 publications

(3 citation statements)

References 38 publications

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“…We created a total of nine different synthetic models with the stenotic levels of 30, 60, and 80% and the lesion locations of anterior (5 mm away from the bifurcation), middle (10 mm away from the bifurcation), and posterior (15 mm away from the bifurcation) of MCA. The MCA was further bifurcated into two arterioles with an angle of 75 • (Jones, 2014). The inlet of the model was located at ICA, while the outlets included one at ACA and two at MCA.…”

Section: Synthetic Modelmentioning

confidence: 99%

Digital Subtraction Angiography Contrast Material Transport as a Direct Assessment for Blood Perfusion of Middle Cerebral Artery Stenosis

Cai

Zhang

et al. 2021

Front. Physiol.

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Digital subtraction angiography (DSA) is a fluoroscopic technique used extensively in interventional radiology for visualizing blood vessels. It has also been used to evaluate blood perfusion. However, the perfusion obtained in previous techniques was extracted from signal intensity rather than by the transport of contrast material (CM) through blood flow. The main aim of this study is to evaluate the morphological effects on the hemodynamics and the CM concentration in the middle cerebral artery (MCA) stenosis. We proposed a quantitative parameter, i.e., contrast material remaining time (CMRT), to describe the variation in the transport of CM over time. Computational fluid dynamics simulations were performed on both reconstructive synthetic and patient-derived models. In the synthetic models, we evaluated the variation of flow patterns and the transport of CM with different degrees of stenosis and the location of the lesion. It was found that an increase in the degree of stenosis (from 30 to 80%) resulted in a significant increase in CMRT at the anterior cerebral artery (ACA) outlet (p = 0.0238) and a significant decrease in CMRT at the MCA outlet (p = 0.012). The patient-derived models were reconstructed from the pre- and post-interventional DSA images of a patient with MCA stenosis. Both blood flow velocity and CMRT increased at the ACA outlet but decreased at the MCA outlet. The perfusion analysis demonstrated that the perfusion function was improved after interventional surgery. In conclusion, changes in stenotic degree at MCA may lead to apparent differences in the hemodynamic distribution and the transport of CM. CMRT could be a quantitative indicator to evaluate the changes in blood perfusion after the intervention for MCA stenosis.

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Section: Synthetic Modelmentioning

confidence: 99%

Digital Subtraction Angiography Contrast Material Transport as a Direct Assessment for Blood Perfusion of Middle Cerebral Artery Stenosis

Cai

Zhang

et al. 2021

Front. Physiol.

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“…Sabe-se que as paredes de vasos sanguíneos possuem certa elasticidade e se movem de acordo com as pulsações cardíacas. No entanto, paredes de artérias cerebrais possuem pouca elastina (Jones, 2014) e segundo Dempere-Marco et al (2006), a inclusão de elasticidade nas paredes em simulações resultou em apenas sutis variações em variáveis hemodinâmicas. Assim, a hipótese de paredes rígidas com condição de aderência foi adotada.…”

Section: Simulaçõesunclassified

Análise Fluidodinâmica Computacional De Escoamento Pulsátil Em Aneurisma

Boite

Wajnberg²,

Klein³

et al. 2018

Anais Do II Congresso Brasileiro De Fluidodinâmica Computacional

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RESUMO-A influência de variáveis hemodinâmicas no crescimento e ruptura de aneurismas tem sido crescentemente investigada com o uso de fluidodinâmica computacional. Perfis de escoamento e da tensão cisalhante são destacados na literatura como sinalizadores de ruptura. Neste trabalho estes parâmetros foram analisados através de simulações CFD em um aneurisma sacular localizado na artéria cerebral média (MCA) utilizando a geometria real de um paciente. Mesmo com a utilização de condições de contorno não específicas do paciente, os resultados mostram corroborar com a literatura.

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“…The three element model does a good job approximating the waveform but has issues when transitioning between systole and diastole [38].…”

Section: Windkessel Modelmentioning

confidence: 99%

Analysis of Particles Thorough the Aortic Arch During Transcatheter Aortic Valve Replacement

Janicki

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Ischemia caused by particles becoming dislodged during transcatheter aortic valve replacement (TAVR) is a possible complication of TAVR. The particles that become dislodged can travel out of the aortic valve, into the aortic arch, and then into either the brachiocephalic artery, the left common carotid artery, the left subclavian artery or continue into the descending aorta. If the particles continue into the descending aorta it poses no risk of causing ischemia however if it travels into the other arteries then it increases the possibility of the particle causing an ischemic event. The goal of this study is to determine what parameters cause the particle to enter one artery over another. The parameters analyzed are the particle diameter, the particle density, the blood pressure, and the diameter of the catheter used in the surgery. This was done by creating a finite element model in COMSOL Multiphysics® to track the particles flowing through a scan of an actual aortic arch. It was determined that the particle diameter, particle density, and the blood pressure affect which artery the particles take to exit the aortic arch. However the diameter of the surgical catheter used in a transaortic approach is not statistically significant when determining which artery the particles will exit. The study shows that larger diameter particle would lead to a higher transmissions probability into the brachiocephalic artery, the left common carotid artery, and the left subclavian artery while a smaller diameter particle would have a higher transmission probability for the descending aorta. Averaging all particle diameters, densities and blood pressure found that 54.95 ± 13.66% of the particles released will travel into the cerebral circulatory system. v

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The Effect of Artery Bifurcation Angles on Fluid Flow and Wall Shear Stress in the Middle Cerebral Artery

Cited by 3 publications

References 38 publications

Digital Subtraction Angiography Contrast Material Transport as a Direct Assessment for Blood Perfusion of Middle Cerebral Artery Stenosis

Digital Subtraction Angiography Contrast Material Transport as a Direct Assessment for Blood Perfusion of Middle Cerebral Artery Stenosis

Análise Fluidodinâmica Computacional De Escoamento Pulsátil Em Aneurisma

Analysis of Particles Thorough the Aortic Arch During Transcatheter Aortic Valve Replacement

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