The effect of azithromycin on reactive oxygen species in rosacea

Bakar, Özgür; Demirçay, Zeynep; Yüksel, Meral; Haklar, Goncagül; Sanisoğlu, Yavuz

doi:10.1111/j.1365-2230.2006.02322.x

Cited by 92 publications

(72 citation statements)

References 23 publications

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“…In rosacea lesions, there was a higher ROS activity and a lower SOD level when compared to the controls [6]. The inhibition of ROS activity in neutrophils with various topical and systemic drugs used in the treatment of rosacea supports the "oxidative stress phenomenon" hypothesis [7][8][9]. On the other hand, PON1 is an enzyme having antioxidant and anti-inflammatory activity and it was found that serum PON1 levels decreased in rosacea [10].…”

Section: Introductionmentioning

confidence: 65%

Decreased arylesterase activity and increased total oxidative status in rosacea

Şener¹,

Fadime²,

Akbaş³

et al. 2017

Our Dermatol Online

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Background: Rosacea is an inflammatory skin disease of face. In recent years, it is revealed that imbalance is significant in oxidant/antioxidant system in pathophysiology. Objective: In this study, the role of oxidative stress on rosacea was investigated. Methods: 34 rosacea patients and 33 healthy control cases between 18 and 70 years old are included in the study. In all the cases, serum lipids, Paraoxonase1(PON1), stimulated Paraoxonase1(stPON1), Arylesterase(ARES), Total Oxidant Status (TOS) and Total Antioxidant Status (TAS) levels are measured. Results: ARES levels were significantly lower and TOS levels were significantly higher in the patient group (p<0,001). Oxidative Stress Index(OSI) was found to be shifted towards the oxidative side in the patient group (p<0,001). Conclusion: This situation shows that oxidative stress may have a role in the rosacea pathophysiology.

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Section: Introductionmentioning

confidence: 65%

Decreased arylesterase activity and increased total oxidative status in rosacea

Şener¹,

Fadime²,

Akbaş³

et al. 2017

Our Dermatol Online

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“…24 The best results of azithromycin are achieved at the end of 4 weeks and maintained until 12 weeks. 64 For prolonged effect, the drug may be used for several months in reduced dosages. A study comparing oral azithromycin with doxycycline for 3 months found both drugs to be equally efficacious, but the azithromycin group had more patients with diarrhea, while the doxycycline group had some patients who experienced epigastric pain.…”

Section: Azithromycinmentioning

confidence: 99%

Ocular Rosacea—a Review

Dhingra¹,

Malhotra²,

Jain³

2017

US Ophthalmic Review

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Ocular rosacea, a disease often associated with acne rosacea, can present with a variety of clinical features, which are often nonspecific. However, in about one-third of cases, it may occur as an isolated entity without skin involvement. Appropriate diagnosis and management is essential as potentially sight-threatening corneal involvement can occur in a significant number of patients if the condition remains unrecognized and untreated. Diagnosis remains mainly clinical and includes recognition of the commonly occurring signs of chronic blepharoconjunctivitis, lid margin telangiectasis,meibomian gland dysfunction, dry eyes, and corneal involvement in the form of vascularization, infiltration, and even perforation. Management depends on the severity of the disease, with milder forms being amenable to treatment with local measures like lid hygiene and topical lubricants, while more severe forms require treatment with systemic drugs including tetracyclines, azithromycin, erythromycin, or metronidazole and more aggressive local therapy with topical steroids and/or topical cyclosporine. Surgical treatment may be required to manage the sequelae of chronic ocular surface inflammation.

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“…Reaktywne formy tlenu (ROS), takie jak aniony nadtlenkowe, rodniki hydroksylowe, tlen cząstecz-kowy i nadtlenek wodoru, powstają jako efekt wydzielania przez granulocyty wielojądrzaste, jak rów-nież w wyniku działania promieni słonecznych, co prowadzi do uszkodzenia tkanek [17,18].…”

Section: Rola Reaktywnych Form Tlenuunclassified

“…Z tego względu podejmowane są ciągle próby stosowania innych leków z tej grupy. Szczególne zainteresowanie wzbudza azytromycyna, która istotnie hamuje powstawanie ROS, ponadto wydaje się hamować produkcję cytokin prozapalnych [17,75] i w szeregu doniesień dotyczących pojedynczych pacjentów lub niewielkich grup chorych okazała się bardzo skuteczna w rosacea [79]. Dotychczas nie ma ustalonego schematu podawania tego leku.…”

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Rosacea – new data on pathogenesis and treatment

Placek¹,

Wolska²

2016

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StreSzczenieTrądzik różowaty jest częstą dermatozą, występującą przeważnie u kobiet i mającą istotny niekorzystny wpływ na jakość życia pacjentów. Obecnie przyjmuje się, że w jego przebiegu mogą przeważać zmiany rumieniowe lub zapalne, a w niektórych przypadkach przerostowe, niekoniecznie stanowiące kolejne etapy nasilenia choroby. Badania ostatnich lat wskazują, że podstawową rolę w rozwoju rosacea odgrywają zaburzona wrodzona odpowiedź immunologiczna i patologie w obrębie ukła-du naczyniowego skóry. Uwzględnia się również podłoże genetyczne i rolę skórnych, ale nie tylko, patogenów (np. Helicobacter pylori, Demodex). W związku z powyższym zalecane metody terapii uwzględniają działanie zarówno przeciwzapalne, jak i ukierunkowane na pasożyty skórne. Podstawowymi preparatami w terapii miejscowej są metronidazol, kwas azelainowy, antybiotyki, leki przeciwpasożytnicze, takie jak iwermektyna, oraz leki oddziałujące wybiórczo na zmiany naczyniowe. W cięższych przypadkach za leki z wyboru uznaje się obecnie tetracykliny, alternatywnie makrolidy, a w skrajnie ciężkich postaciach izotretynoinę. W związku z bezsprzeczną, co najmniej pogarszającą chorobę rolą promieniowania ultrafioletowego (UV) zaleca się rygorystyczną ochronę przed UV, a także -co również wynika z obserwacji klinicznych -odpowiednią dietę. Wraz z postępem techniki coraz większe znaczenie w leczeniu rosacea mają różnego typu terapie świetlne. AbStrActRosacea is a common dermatosis more prevalent in females, significantly impairing quality of life. Currently erythematous, papulo-pustular and phymatous subtypes are distinguished, which do not necessarily represent consecutive stages. Recent findings indicate in the pathogenesis of rosacea the role of the impaired innate immune system and vascular abnormalities. Additionally, the role of genetic and infectious factors is suggested. The therapy of rosacea is directed not only against inflammatory changes but also anti-parasitic. In topical treatment the most commonly used are metronidazole and azelaic acid. Other drugs are topical antibiotics, antiparasitic agents such as ivermectin and preparations directly influencing erythema. In more severe cases tetracyclines or macrolides are used, and in the most severe cases, isotretinoine. As ultraviolet light is a recognized trigger for rosacea, regular sunscreen use is necessary. Also, proper diet is indicated. Presently in the treatment of rosacea more and more techniques using different lights are employed.

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The effect of azithromycin on reactive oxygen species in rosacea

Abstract: Rosacea patients have higher ROS levels than healthy controls. The results of our study support the antioxidant properties of azithromycin in rosacea.

Cited by 92 publications

References 23 publications

Decreased arylesterase activity and increased total oxidative status in rosacea

Decreased arylesterase activity and increased total oxidative status in rosacea

Ocular Rosacea—a Review

Rosacea – new data on pathogenesis and treatment

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