The Effect of Beta-Cyclodextrin on Percutaneous Absorption of Commonly Used Eusolex® Sunscreens

Shokri, Javad; Hasanzadeh, D.; Ghanbarzadeh, Saeed; Dizadji-Ilkhchi, M.; Adibkia, Khosro

doi:10.1055/s-0033-1349089

Cited by 10 publications

(4 citation statements)

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“…Shokri et al [36] investigated the fate of AVO, BP-3 and ESZ formulated in a cosmetic O/W emulsion as free filters or included in a complex with β-cyclodextrin in permeation studies through abdominal skin of Wistar rats, which were shaved with razors 24 h prior of the experiments. It is necessary to emphasize that these products are among the most common UV filters on the market and that, after cutaneous application, in vivo have been demonstrated to permeate the skin in significant amounts.…”

Section: In Vitro Methodsmentioning

confidence: 99%

“…In order to increase the dimension of the solar filter and its concentration in the upper stratum corneum, the formation of inclusion complexes with cyclodextrins has been investigated, also to increase the sunscreen photostability. Shokri et al [36] prepared an inclusion complex of β-cyclodextrin with three different UV filters (AVO, BP-3 and ESZ) by different methods, i.e., co-evaporation, grinding and kneading. They found that the complexation reduced the rate of permeation of sunscreens with respect to when the free filter was taken in account, also increasing the lag time, while the physical mixture affected permeation only for a little extent.…”

Section: Formulation Strategiesmentioning

confidence: 99%

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Cutaneous Permeation and Penetration of Sunscreens: Formulation Strategies and In Vitro Methods

et al. 2017

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Sunscreens are the most common products used for skin protection against the harmful effects of ultraviolet radiation. However, as frequent application is recommended, the use of large amount of sunscreens could reflect in possible systemic absorption and since these preparations are often applied on large skin areas, even low penetration rates can cause a significant amount of sunscreen to enter the body. An ideal sunscreen should have a high substantivity and should neither penetrate the viable epidermis, the dermis and the systemic circulation, nor in hair follicle. The research of methods to assess the degree of penetration of solar filters into the skin is nowadays even more important than in the past, due to the widespread use of nanomaterials and the new discoveries in cosmetic formulation technology. In the present paper, different in vitro studies, published in the last five years, have been reviewed, in order to focus the attention on the different methodological approaches employed to effectively assess the skin permeation and retention of sunscreens.

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Section: In Vitro Methodsmentioning

confidence: 99%

Section: Formulation Strategiesmentioning

confidence: 99%

Cutaneous Permeation and Penetration of Sunscreens: Formulation Strategies and In Vitro Methods

et al. 2017

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“…Al-Rawashdeh et al (2010) reported the micro-encapsulation of commercial UV filters (oxybenzone ( 10 ), EHMC ( 21 ), and octocrylene ( 30 )) in hydroxypropyl-β-cyclodextrins system that successfully acted as photostabilisers [ 44 ]. Studies with cyclodextrins encapsulation using other UV filters have been also reported [ 45 , 46 , 47 ]. Moreover, the stabilisation of avobenzone ( 11 ) mediated by the combination with other UV filters, such methylbenzylidene camphor ( 7 ) or octocrylene ( 30 ) [ 48 ], or with bis-ethylhexyloxyphenol methoxyphenyl triazine ( 27 ) [ 35 ], was proved as an advantageous option that confers more stability to the photounstable UV filters.…”

Section: Challengesmentioning

confidence: 99%

UV Filters: Challenges and Prospects

et al. 2022

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The use of sunscreens is an established and recommended practice to protect skin from solar-induced damage. Around 30 UV filters can be used in sunscreen products in the European Union, which ought to follow the requirements of the regulation 1223/2009 to ensure their efficacy and safety for humans. Nevertheless, low photostability and putative toxicity for humans and environment have been reported for some UV filters. Particularly, the negative impact in marine organisms has recently raised concern on the scientific community. Therefore, it is important to develop new UV filters with improved safety profile and photostability. Over the last two decades, nearly 200 new compounds have revealed promising photoprotection properties. The explored compounds were obtained through different approaches, including exploration of natural sources, synthetic pathways, and nanotechnology. Almost 50 natural products and around 140 synthetic derivatives, such as benzimidazoles, benzotriazoles, hydroxycinnamic acids, xanthones, triazines, among others, have been studied aiming the discovery of novel, effective, and safer future photoprotective agents. Herein, we provide the reader with an overview about UV filters’ challenges and prospects, offering a forward-looking to the next-generation of UV filters.

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“…Likewise, the inclusion complex of oxybenzone in HPβ-CD and sulfobutylether-β-CD (SBE-β-CD) led to an increase in the aqueous solubility of oxybenzone (up to 1049-fold) whilst significantly limiting its percutaneous absorption (Figure 7) [81]. Furthermore, Shokri et al reported that the absorption lag time and overall percutaneous flux of avobenzone, oxybenzone, and ensulizole were reduced by 4 to 15-fold after complexation with β-CD [82]. Due to its relatively low price and its absorption of both UVA and UVB radiation, UV filter benzophenone-3 is regularly used in sunscreen formulations.…”

Section: Uv Filters/cds Inclusion Complexmentioning

confidence: 99%

Sunscreens Containing Cyclodextrin Inclusion Complexes for Enhanced Efficiency: A Strategy for Skin Cancer Prevention

et al. 2021

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Unprotected exposure of skin to solar ultraviolet radiation (UVR) may damage the DNA of skin cells and can lead to skin cancer. Sunscreens are topical formulations used to protect skin against UVR. The active ingredients of sunscreens are UV filters that absorb, scatter, and/or reflect UVR. Preventing the formation of free radicals and repairing DNA damages, natural antioxidants are also added to sunscreens as a second fold of protection against UVR. Antioxidants can help stabilise these formulations during the manufacturing process and upon application on skin. However, UV filters and antioxidants are both susceptible to degradation upon exposure to sunlight and oxygen. Additionally, due to their poor water solubility, natural antioxidants are challenging to formulate and exhibit limited penetration and bioavailability in the site of action (i.e., deeper skin layers). Cyclodextrins (CDs) are cyclic oligosaccharides that are capable of forming inclusion complexes with poorly soluble drugs, such as antioxidants. In this review, we discuss the use of CDs inclusion complexes to enhance the aqueous solubility of antioxidants and chemical UV filters and provide a protective shield against degradative factors. The role of CDs in providing a controlled drug release profile from sunscreens is also discussed. Finally, incorporating CDs inclusion complexes into sunscreens has the potential to increase their efficiency and hence improve their skin cancer prevention.

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The Effect of Beta-Cyclodextrin on Percutaneous Absorption of Commonly Used Eusolex® Sunscreens

Abstract: Considering the ability of β-CDX complexation in the reduction of flux and enhancement ratio as well as prolongation of absorption lag time, this technique could be very helpful for reducing systemic absorption of the UV filters and subsequent toxicity and allergic reaction.

Cited by 10 publications

References 1 publication

Cutaneous Permeation and Penetration of Sunscreens: Formulation Strategies and In Vitro Methods

Cutaneous Permeation and Penetration of Sunscreens: Formulation Strategies and In Vitro Methods

UV Filters: Challenges and Prospects

Sunscreens Containing Cyclodextrin Inclusion Complexes for Enhanced Efficiency: A Strategy for Skin Cancer Prevention

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