The Effect of Black Raspberry Extracts on MnSOD Activity in Protection Against Concanavalin A Induced Liver Injury

Li, Xuanyi; Li, Yan; States, Vanessa; Li, Suping; Zhang, Xiang; Martin, Robert C.

doi:10.1080/01635581.2014.922201

Cited by 12 publications

(8 citation statements)

References 34 publications

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“…A similar effect was observed in infections caused by influenza A virus where inclusion of MnSOD in aerosols led to a mild improvement of the disease. Other natural antimicrobials are also known for their antioxidant effect 12 also when included in the feed of farmed poultr 34 with a direct effect in controlling the levels of MnSOD 35 .…”

Section: Discussionmentioning

confidence: 99%

Antiviral activity of a novel mixture of natural antimicrobials, in vitro, and in a chicken infection model in vivo

Balta

Ştef

Peţ

et al. 2020

Sci Rep

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The aim of this study was to test in vitro the ability of a mixture of citrus extract, maltodextrin, sodium chloride, lactic acid and citric acid (AuraShield L) to inhibit the virulence of infectious bronchitis, Newcastle disease, avian influenza, porcine reproductive and respiratory syndrome (PRRS) and bovine coronavirus viruses. Secondly, in vivo, we have investigated its efficacy against infectious bronchitis using a broiler infection model. In vitro, these antimicrobials had expressed antiviral activity against all five viruses through all phases of the infection process of the host cells. In vivo, the antimicrobial mixture reduced the virus load in the tracheal and lung tissue and significantly reduced the clinical signs of infection and the mortality rate in the experimental group E2 receiving AuraShield L. All these effects were accompanied by a significant reduction in the levels of pro-inflammatory cytokines and an increase in IgA levels and short chain fatty acids (SCFAs) in both trachea and lungs. Our study demonstrated that mixtures of natural antimicrobials, such AuraShield L, can prevent in vitro viral infection of cell cultures. Secondly, in vivo, the efficiency of vaccination was improved by preventing secondary viral infections through a mechanism involving significant increases in SCFA production and increased IgA levels. As a consequence the clinical signs of secondary infections were significantly reduced resulting in recovered production performance and lower mortality rates in the experimental group E2.

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Section: Discussionmentioning

confidence: 99%

Antiviral activity of a novel mixture of natural antimicrobials, in vitro, and in a chicken infection model in vivo

Balta

Ştef

Peţ

et al. 2020

Sci Rep

View full text Add to dashboard Cite

show abstract

“…A volume of 10 μL of sample or standard was added to 200 μL of diluted “radical detector” in a 96‐well plate. Addition of 1 mmol/L potassium cyanide (KCN) was used to block Cu/Zn‐SOD and extracellular SOD activity, resulting in detection of only Mn‐SOD activity in samples (Li et al ). Reactions were initiated by adding 20 μL of supplied xanthine oxidase using a multichannel pipette.…”

Section: Methodsmentioning

confidence: 99%

Optimization of Dietary Manganese for Rainbow Trout, Oncorhynchus mykiss, Fed a Plant‐based Diet

Welker

Overturf

Abernathy

et al. 2017

J World Aquaculture Soc

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Juvenile rainbow trout were fed a plant-based diet supplemented with inorganic Mn added at 0, 0.5, 1, 2, 4, 8, 16, or 32 mg/kg diet for 12 wk. Whole-body Mn concentrations increased with increasing dietary levels. Rainbow trout fed 2-8 mg Mn/kg diet exhibited weight gain that was significantly higher than fish fed 0, 0.5, 1, 16, and 32 mg Mn/kg diet. Feed conversion ratio (FCR) showed a similar trend, where FCR values decreased with increasing dietary Mn until concentrations reached 8 mg Mn/kg, after which they increased. A rational nonlinear model (R 2 = 0.84) fit to weight-gain data showed that the optimal predicted supplementation level for Mn was 4.8 mg/kg diet. The optimal predicted supplementation level for Mn was similar for FCR (5 mg Mn/kg diet). The predicted 5 mg/kg diet of supplemental Mn required for the plant-based diet formulation examined in this study is lower than the National Research Council-recommended supplementation level of 12 mg/kg. However, due to potential differences in bioavailability or retention of Mn among plant-protein sources, the level of dietary supplementation for optimal growth could be slightly higher or lower depending on the dietary formulation.

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“…Numerous reports have revealed potential therapeutic approaches to improve Con A-induced liver injury through suppression of oxidative stress and apoptotic cell death 34 – 36 . Our results indicated that the MDA level was significantly increased in the aged mice compared with that of the young mice, and a further elevation was observed in aged mice after Con A challenge (Fig.…”

Section: Resultsmentioning

confidence: 99%

Resveratrol Pretreatment Attenuates Concanavalin A-induced Hepatitis through Reverse of Aberration in the Immune Response and Regenerative Capacity in Aged Mice

Huang

Chen

Liu³

et al. 2017

Sci Rep

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Loss of regenerative capacity plays a critical role in age-related autoimmune hepatitis. Evidence implicates SIRT1 and p66shc in cell senescence, apoptosis, oxidative stress, and proliferation. This study investigated the effect of resveratrol on concanavalin A (Con A)-induced hepatitis in aged mice and the roles of SIRT1 and p66shc. Aged mice were administrated resveratrol (30 mg/kg orally) seven times at an interval of 12 h before a single intravenous injection of Con A (20 mg/kg). Results showed that the cytokines, TNF-α, IL-6, IFN-γ, and MCP-1, as well as infiltration of macrophages, neutrophils, and T lymphocytes in liver were dramatically enhanced in the mice given only Con A. The aged mouse livers showed markedly raised oxidative stress and cell apoptosis. This oxidative stress further aggravated regenerative dysfunction as indicated by the decreased levels of Ki67, PCNA, Cyclin D1, and Cdk2. Conversely, these phenomena were attenuated by pretreatment with resveratrol. Moreover, resveratrol suppressed the elevation of p66shc in the liver by reversing Con-A-mediated downregulation of SIRT1. The findings suggest that resveratrol protected against Con A-induced hepatitis in aged mice by attenuating an aberration of immune response and liver regeneration, partially via the mechanism of SIRT1-mediated repression of p66shc expression.

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The Effect of Black Raspberry Extracts on MnSOD Activity in Protection Against Concanavalin A Induced Liver Injury

Cited by 12 publications

References 34 publications

Antiviral activity of a novel mixture of natural antimicrobials, in vitro, and in a chicken infection model in vivo

Antiviral activity of a novel mixture of natural antimicrobials, in vitro, and in a chicken infection model in vivo

Optimization of Dietary Manganese for Rainbow Trout, Oncorhynchus mykiss, Fed a Plant‐based Diet

Resveratrol Pretreatment Attenuates Concanavalin A-induced Hepatitis through Reverse of Aberration in the Immune Response and Regenerative Capacity in Aged Mice

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