The effect of blood glucose regulation on sarcopenia parameters in obese and diabetic patients

Öztürk, Zeynel Abidin; Türkbeyler, İbrahim Halil; Demir, Zeynep; Bilici, Muhammet; Kepekçi, Yalçı́n

doi:10.5606/tftrd.2018.1068

Cited by 12 publications

(16 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Pearson or Spearman correlation analysis was used to test correlations between the variables, depending on the distribution of the parameters (r=0.00; no correlation, r=0.01-0.29 range; low level correlation, r=0.30 -0.70; medium level correlation, r=0.71 -0.99; high level correlation, r=1.00; perfect correlation). 13 A p value <0.05 was considered as statistically significant.…”

Section: Discussionmentioning

confidence: 99%

Postural Stability and Risk of Fall in Vitamin B12 Deficiency

Kul¹,

Bilge²,

Uzkeser³

et al. 2020

J PMR Sci

View full text Add to dashboard Cite

We aimed to evaluate postural stability and risk of fall in patients with asymptomatic vitamin B12 deficiency. Material and Methods: Fifty patients (34 women, 16 men; mean age ± SD: 35±12 years; age range: 18-58 years) who applied to physical medicine and rehabilitation outpatient clinic due to complaints of upper extremity with vitamin B12 deficiency (<200 pq/dl) and without neuropathy according to electromyography results were included in the study. In addition, a total of 49 healthy control subjects (mean age 34±8 years; range 24 to 60 years), 35 females and 14 males with similar age and sex, were included. Gender, age, body mass index (BMI) values and fall history in the last year of the participants were recorded. Fear of falling was evaluated with the Falls Efficacy Scale International (FES-I). With the Tetrax interactive balance system, which is an objective computerized method, posturographic evaluation of the participants was made. In the evaluation of postural stability; the stability index (SI) based on the displacement of the center of gravity and weight distribution index (WDI) on 4 platforms were used. On the other hand, the fall risk results were determined as a numerical value between 0-100. Postural stability and fall risk analyses were evaluated according to the results of the posturographic examination. Results: In the patient group, fall history, FES-I score, some SI values and the risk of falling were significantly higher (p<0.05). There was no significant relationship between FES-I and gender, age, BMI, and history of fall, while there was a weak negative correlation between some SI values and fall risk (r=0.03 and p<0.05). However, there was no correlation between the severity of vitamin B12 deficiency and the risk of falling. Conclusions: It was found that postural stability is affected, and the risk of fall is increased in patients with asymptomatic vitamin B12 deficiency. This increase in risk of fall was found to be associated with vitamin B12 deficiency but not with the severity of the deficiency.

show abstract

Section: Discussionmentioning

confidence: 99%

Postural Stability and Risk of Fall in Vitamin B12 Deficiency

Kul¹,

Bilge²,

Uzkeser³

et al. 2020

J PMR Sci

View full text Add to dashboard Cite

show abstract

“…Morley and colleagues reported that the prevalence of sarcopenia was higher in diabetic than in nondiabetic individuals in Korea, India, and the UK [34]. Moreover, a previous study showed that patients with improved blood glucose regulation demonstrated improved physical functions, including gait speed and handgrip strength [35]. Abnormal fasting glucose level (>126 mg/dL) was selected as an independent predictor of sarcopenia in the TRSS model, after adjusting for history of diabetes mellitus and other comorbidities.…”

Section: The Associations Between Sarcopenia and Items From Trss Modelmentioning

confidence: 99%

Development of Taiwan Risk Score for Sarcopenia (TRSS) for Sarcopenia Screening among Community-Dwelling Older Adults

Tseng

Hsiao

et al. 2020

IJERPH

View full text Add to dashboard Cite

The SARC-F questionnaire has been suggested by the European Working Group on Sarcopenia in Older People (EWGSOP) as a first-step screening tool for sarcopenia. However, the sensitivity to SARC-F is low among community-dwelling older adults. Therefore, this study aimed to develop a new prediction model for sarcopenia screening in the community setting. We conducted a cross-sectional analysis of data from the Taiwan Integration of Health and Welfare (TIHW) study. Covariates including comorbidities, socioeconomic status, social support, health behaviors, body composition, and serum biomarkers were collected for analysis. Sarcopenia was defined using handgrip strength and gait speed cut-off values suggested by the Asian Working Group for Sarcopenia. Risk scores for sarcopenia were estimated by stepwise logistic regression. Among 1025 participants (mean age, 71.95 ± 6.89 years), 179 (17.5%) had sarcopenia. Seven items, including age, female sex, receiving social assistance pension, absence of exercise, being underweight, abnormal fasting glucose levels, and abnormal creatinine levels were selected for the Taiwan Risk Scores for Sarcopenia (TRSS) with a cutoff value of 76 (sensitivity, 71.8%; specificity, 71.1%) and area under the curve (AUC) of 0.757. Our results suggested that the TRSS model could be applied cost-effectively in the community for early detection of sarcopenia.

show abstract

“…5 Due to this important role in glucose utilization, loss of skeletal muscle mass (sarcopenia) will worsen insulin resistance (IR) in T2DM. 6 Macroautophagy (autophagy) is a process in a cell characterized by developing a closed double-membrane vesicle called the autophagosome. The autophagosome then fused with the lysosome to degrade its content.…”

Section: Introductionmentioning

confidence: 99%

The effect of metformin on autophagy by LC3 expression in Type 2 Diabetes Mellitus (T2DM) human skeletal muscle cell culture

Prajitno

Pranoto

Adiwinoto³

et al. 2022

Bali Med J.

View full text Add to dashboard Cite

Background: Skeletal muscle is an essential tissue in glucose metabolism. Reduced autophagic capacity to remove damaged contractile proteins in skeletal muscle cells will contribute to the loss of muscle mass. Metformin is the first-line agent for treating type 2 diabetes mellitus (T2DM) patients. This study aims to investigate the effects of metformin on autophagy through LC3 expression in human skeletal muscle cell culture (SkMC). Methods: The T2DM human SkMC was obtained from T2DM treatment naïve patients, purchased from AcceGen Biotech®. Fully differentiated myotubes were randomized into the control and treatment groups. The treatment group was given Metformin in three doses (1 mM, 2 mM, and 3 mM). An immunoblotting assay of AMPKα and LC3 was performed using electrochemiluminescence (ECL). The quantitative expression of AMPKα and LC3 were measured at baseline, after 24-hour, 48-hour, and 72-hour. Data were analyzed using SPSS version 22 for Windows.Results: AMPKα and LC3 expression were higher in the treatment group compared to the control group. The levels of AMPKα and LC3 expression in the treatment group increased dose-dependent. Linear regression analysis demonstrated a significant correlation between metformin administration and LC3 expression levels (p<0.0001). Conclusion: Metformin administration on T2DM human SkMC resulted in increased autophagic activity, marked by increased LC3 expression.

show abstract

The effect of blood glucose regulation on sarcopenia parameters in obese and diabetic patients

Cited by 12 publications

References 53 publications

Postural Stability and Risk of Fall in Vitamin B12 Deficiency

Postural Stability and Risk of Fall in Vitamin B12 Deficiency

Development of Taiwan Risk Score for Sarcopenia (TRSS) for Sarcopenia Screening among Community-Dwelling Older Adults

The effect of metformin on autophagy by LC3 expression in Type 2 Diabetes Mellitus (T2DM) human skeletal muscle cell culture

Contact Info

Product

Resources

About