The effect of caffeic acid phenethyl ester on isoproterenol-induced myocardial injury in hypertensive rats

İlhan, Selçuk; Yılmaz, Nigar; Nacar, Emel; Motor, Sedat; Oktar, Süleyman; Şahna, Engin

doi:10.5152/akd.2014.4825

Cited by 16 publications

(8 citation statements)

References 38 publications

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“…In accordance with our results, Ilhan et al shown that SOD and CAT enzyme activities decreased when compared to control group. 43 There were significantly decreased GPX levels in the ISOtreated group when compared to the control, DEX+ISO and ISO+DEX groups. In parallel to our results, Panda and Kar 44 reported that GPX declined significantly in ISOtreated rats as compared to the respective values of normal control rats.…”

Section: Discussionmentioning

confidence: 84%

Protective and therapeutic effects of dexpanthenol on isoproterenol‐induced cardiac damage in rats

Kalkan

Parlakpınar

Disli

et al. 2018

J of Cellular Biochemistry

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The purpose of the study was to explore the protective and therapeutic effects of dexpanthenol (DEX) on isoproterenol (ISO)-induced cardiac damage. Forty rats were distributed into four groups: group I (Control); group II (ISO); ISO (150 mg/kg/day) was given to rats once a day for 2 consecutive days with an interval of 24 h; group III (DEX+ISO): DEX (250 mg/kg) was applied 30 min before the first ISO administration and continued in the next two days after second ISO administration; group IV (ISO+DEX): After the ISO treatment at 1st and 2nd days, DEX was given at 3rd and 4th days. Rats were monitored for mean arterial blood pressure (BP), heart rate, oxygen saturation (%SO ), and electrocardiography (ECG). Heart tissue levels of malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX), reduced glutathione (GSH), total oxidant status (TOS); total antioxidant capacity (TAC), oxidative stress index (OSI), and caspase-3 were determined. BP and SO values indicated a significant decrease in the ISO group. Also, T wave negativity was observed in 6 of 10 rats, SOD, CAT, and GPX levels were significantly lower in ISO group than control group. ISO administration increased TOS and OSI levels, whereas DEX treatment significantly reduced these parameters. Also, ISO-induced morphological alterations such as disorganization of cardiomyocytes, loss of myofibrils and cytoplasmic vacuolization whereas these histological damages were significantly decreased in ISO+DEX and DEX+ISO groups when compared to the ISO group. This study implies the cardioprotective effects of DEX on ISO-induced cardiotoxicity.

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Section: Discussionmentioning

confidence: 84%

Protective and therapeutic effects of dexpanthenol on isoproterenol‐induced cardiac damage in rats

Kalkan

Parlakpınar

Disli

et al. 2018

J of Cellular Biochemistry

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“…Our results were in agreement with many authors; Li et al, (48) reported a significant increase in the levels of lipid peroxidation products (MDA) in ISOinduced rats due to oxidative damage and increased production of free radicals. İlhan et al, (49) demonstrated that, a decrease in SOD and CAT activities in ISO given rats and oxidative stressmediated possible MI. This is due to the fact that excessive superoxide anions may inactivate SOD enzyme, which convert superoxide anion free radicals (O 2 -) to H 2 O 2 and to molecular oxygen (50) .…”

Section: Histological Studies In All Studied Groupsmentioning

confidence: 99%

Cardio-Protective Effect of Rooibos against Isoproterenol Induced Myocardial Infarction in Male Albino Rats

Fekry

Ezz

Keshta

et al. 2014

Biochemistry Letters

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Background: Myocardial infarction (MI) is the most lethal manifestation of cardiovascular disease, cause morbidity and mortality in the world. Rooibos (Aspalathus linearis) naturally derived plant, used as a traditional medicine against cardiovascular diseases (CVD). Aim: The present study aims to elucidate whether rooibos possesses cardio-protective effect against MI driven by isoproterenol (ISO). Materials & Methods: Swiss male adult albino rats were divided into 5 groups: 1 st gp served as negative control; 2 nd gp served as Rooibos group administrated orally 3 times a week for 8 weeks, ‫‬ 3 rd gp served as ISO group injected with 85 mg/kg S.C. for days 54, 55; 4 th gp served as preventive group rooibos administrated then ‫‬ injected with ISO; and 5 th gp served as therapeutic group ‫‬ injected with ISO then rooibos administrated. Blood and tissues samples were collected for some biochemical and histopathological studies. Results: Isoproterenol induced MI that characterized by alterations in cardiac markers and functions, enhanced the levels of antioxidant level in heart tissue, and induced myocardial necrosis and inflammation; as these changes were accompanied with elevation of lipid profile except HDL. Our data resulted in Rooibos could ameliorate cardiac injury (aspartate transferase, lactate dehydrogenase, creatine kinase-MB, troponin and Galectin-3), up-regulate antioxidant systems (decreasing MDA and increasing superoxide dismutase, catalase, glutathione reduced, glutathione peroxidase in heart homogenate), and maintain the levels of circulating lipids driven by ISO as well. Rooibos showed significant preventive effects in all the biochemical and histological studies in myocardial infarcted rats rather than therapeutic ones. Conclusions: Rooibos extract may be apparently safe and non-toxic exerts strong favorable cardio-protective action in ISO induced rats due to high antioxidant capacity that decrease the oxidative stress, anti-dyslipidemia, and inhibition of lipid peroxidation.

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“…On the one hand, CAPE may have a positive inotropic agent (induction of beta adrenergic receptor by NO) and promote coronary vasodilation by increasing cardiac output; on the other hand it may decrease peripheral resistance by its vasorelaxant effect. In this way, the mean blood pressure might remain stable (Ilhan et al, 2014). For this reason, the effect of CAPE and other CA derivatives on hemodynamics should be clarified in vivo by simultaneously assessing perfusion and blood pressure.…”

Section: Caffeic Acid Phenethyl Estermentioning

confidence: 99%

Cardiovascular Effects of Caffeic Acid and Its Derivatives: A Comprehensive Review

Silva

Lopes

2020

Front. Physiol.

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Caffeic acid (CA) and its phenethyl ester (CAPE) are naturally occurring hydroxycinnamic acids with an interesting array of biological activities; e.g., antioxidant, anti-inflammatory, antimicrobial and cytostatic. More recently, several synthetic analogs have also shown similar properties, and some with the advantage of added stability. The actions of these compounds on the cardiovascular system have not been thoroughly explored despite presenting an interesting potential. Indeed the mechanisms underlying the vascular effects of these compounds particularly need clarifying. The aim of this paper is to provide a comprehensive and up-to-date review on current knowledge about CA and its derivatives in the cardiovascular system. Caffeic acid, CAPE and the synthetic caffeic acid phenethyl amide (CAPA) exhibit vasorelaxant activity by acting on the endothelial and vascular smooth muscle cells. Vasorelaxant mechanisms include the increased endothelial NO secretion, modulation of calcium and potassium channels, and modulation of adrenergic receptors. Together with a negative chronotropic effect, vasorelaxant activity contributes to lower blood pressure, as several preclinical studies show. Their antioxidant, anti-inflammatory and anti-angiogenic properties contribute to an important anti-atherosclerotic effect, and protect tissues against ischemia/reperfusion injuries and the cellular dysfunction caused by different physico-chemical agents. There is an obvious shortage of in vivo studies to further explore these compounds’ potential in vascular physiology. Nevertheless, their favorable pharmacokinetic profile and overall lack of toxicity make these compounds suitable for clinical studies.

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The effect of caffeic acid phenethyl ester on isoproterenol-induced myocardial injury in hypertensive rats

Cited by 16 publications

References 38 publications

Protective and therapeutic effects of dexpanthenol on isoproterenol‐induced cardiac damage in rats

Protective and therapeutic effects of dexpanthenol on isoproterenol‐induced cardiac damage in rats

Cardio-Protective Effect of Rooibos against Isoproterenol Induced Myocardial Infarction in Male Albino Rats

Cardiovascular Effects of Caffeic Acid and Its Derivatives: A Comprehensive Review

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