The effect of cell type on surgico-pathologic risk factors in endometrial cancer

Turan, Ahmet Taner; Dündar, Betül; Gündoğdu, Burcu; Boztosun, Abdullah; Özgül, Nejat; Boran, Nurettin; Tulunay, Gökhan; Özfuttu, Ahmet; Köse, Mehmet

doi:10.5152/jtgga.2011.03

Cited by 3 publications

(4 citation statements)

References 25 publications

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“…Lymphatic spread is an important prognostic factor representing the most common extrauterine area of disease spread in endometrial cancer. Nodal metastasis is detected in 5% of women who are supposed to have low-risk endometrial cancer and 22% of women who are supposed to have moderate-risk endometrial cancer (10) 16), tumor size (17), and tumor type (18) as important factors in determining extrauterine spread. The present study identified the presence of LVI, cervical invasion, peritoneal cytology positivity and tumor type as independent prognostic factors for predicting extrauterine spread.…”

Section: Discussionmentioning

confidence: 99%

A model for predicting extrauterine tumor spread in patients with endometrial cancer

Karayünlü

Ünsal

Kılıç

et al. 2023

Hitit Medical Journal

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A model for predicting extrauterine tumor spread in patients with endometrial cancer Abstract Background: The factors predicting extrauterine spread in patients undergoing staging surgery with the diagnosis of endometrial cancer were investigated. Aims: The study aimed to create a model using demographic, surgical, and pathological factors to predict extrauterine spread. Methods: Included in the study were 355 patients with a final diagnosis of endometrial cancer who underwent surgery for staging purposes. The effect of surgical-prognostic factors on extrauterine spread was analyzed using univariate analysis and multivariate logistic regression analysis. Results: Extrauterine spread was detected in 97 patients. A multivariate logistic regression model that was created to determine the factors affecting extrauterine spread identified the presence of lymphovascular invasion, cervical invasion, peritoneal cytology positivity and tumor type as independent factors. A model was created using these four independent risk factors. According to this model, the rate of extrauterine spread was 6.4% in patients who did not have the risk factors and 100% in patients who had all the risk factors (p

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Section: Discussionmentioning

confidence: 99%

A model for predicting extrauterine tumor spread in patients with endometrial cancer

Karayünlü

Ünsal

Kılıç

et al. 2023

Hitit Medical Journal

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“…Hücre tiplerine göre lenf nodu metastazlarını inceleyen bir çalışmada, agresif hücre tipli endometrium kanserli olgularda pelvisin tüm bölgelerinde metastaz saptanırken, para-aortik lenf nodu metastazının hücre tipinden bağımsız olduğu bildirilmiştir (9) . Bizim çalışmamızda agresif hücre tipi komponenti olan olgularda pelvik ve para-aortik lenf nodu metastazı varlığı anlamlı düzeyde daha yüksek bulunmuştur (p=0,041).…”

Section: Discussionunclassified

“…Peritoneal sitoloji pozitifliği dört hastada, adneksiyal tutulum altı hastada ve servikal stromal invazyon 11 hastada saptandı. Omentumun değerlendirildiği 32 hastanın 30'unda (%90, 9) omental metastaz saptanmadı. Hastaların cerrahi patolojik verileri Tablo 1'de ayrıntılı olarak belirtilmiştir.…”

Section: Bulgularunclassified

Analysis of mixed type endometrial carcinoma

Duzguner¹,

Ilgın²,

Taşçı³

et al. 2014

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Amaç: Bu çalışmanın amacı miks tip endometrium kanserinde görülen lokal cerrahi-patolojik faktörler ve bu faktörlerin hücre tipleri ile olan ilişkisini incelemektir. Gereç ve Yöntemler: Ocak 1993-Mayıs 2013 yılları arasında nihai tanısı miks hücre tipi endometrium kanseri olan 33 olguya ait veriler retrospektif olarak değerlendirildi. Bulgular: Endometrium kanseri tanısı alıp tedavisi yapılmış 1640 hastanın 33'ü (%2) miks hücre tipine sahipti. Hasta grubunun ortalama yaşı 60 yıldı. 2009 FIGO evreleme sistemine göre hastaların 18'i evre 1'di. Tümör beş olguda (%15,2) endometrioid ve seröz, 12 olguda (%36,4) endometrioid ve berrak hücreli, 12 olguda (%36,4) endometrioid ve müsinöz, dört olguda (%12,1) seröz ve berrak hücreli kompanentten oluşmaktaydı. Yirmi bir olguda (%63,6) berrak hücreli veya seröz kompanentlerden en az biri mevcuttu. Lenf nodu metastazı varlığı sadece berrak hücreli veya seröz hücre tiplerinden en az birini içeren olgularda izlendi (p=0,041). Yaş, tümör boyutu, evre, myometrial invazyon varlığı ve derinliği, servikal yayılım, lenfovasküler alan invazyonu, adneksiyal tutulum, peritoneal sitoloji ve çıkarılan lenf nodu sayısı berrak hücre ve/veya seröz hücre tipini içeren ve içermeyen olgularda istatistiksel olarak benzer bulundu. Median takip süresi 24 aydı ve bu süre içerisinde iki hastada rekürrens gelişti ve bir hastada adjuvan tedavi sırasında progresyon izlendi. Bu üç hastanın ikisinde agresif hücre tipi mevcuttu ve bunlar evre IV-B tümör olup lenf nodu metastazına sahiptiler. Diğer hastada tümör endometrioid ve müsinöz kompanentlerden oluşmakta olup servikal stromal invazyon izlendi. Sonuç: Tümörün seröz veya berrak hücre kompanenti içermesi sağ kalım açısından önemli prognostik faktör olan lenf nodu metastazını belirlemekteydi. J Turk Soc Obstet Gynecol 2014;2:119-25 Anahtar Kelimeler: Miks tip, berrak hücreli, seröz tümör Objective: To analyze local surgical-pathological factors of mixed type endometrial carcinoma and to examine their relationship with cell types. Material and Methods: Data of 33 cases, definitely diagnosed with mixed type endometrial carcinoma between January 1993 and May 2013, were examined retrospectively. Results: Of 1640 patients diagnosed with endometrial carcinoma and received treatment, 33 (2%) had mixed cell type. Average age of the study group was 60 years. According to the FIGO 2009 staging, 18 patients were stage I. Tumors were composed of endometrioid and serous components in 5 cases (15.2%), endometrioid and clear cell components in 12 cases (36.4%), endometrioid and mucinous components in 12 cases (36.4%) and serous and clear cell components in 4 cases (12.1%). In 21 cases (63.6%) at least one of the serous and clear cell components was present. The presence of lymph node metastasis was noticed only in cases composed of serous or clear cell type of endometrial carcinoma (p=0.041). Other surgical-pathological factors such as age, tumor size, grade, presence and depth of myometrial invasion, cervical and lymphovascular area invasion, adnexal involvement, per...

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“…Although ECa is the most common gynecologic cancer worldwide and numerous studies have been performed on risk factors or prognostic factors, the underlying carcinogenic mechanisms remain unknown (24,25). Unopposed and prolonged estrogen stimulation, including stimulation by nulliparity, late menopause, and obesity, has been identified as a risk factor for the development of ECa.…”

Section: Discussionmentioning

confidence: 99%

Association of endothelial nitric oxide synthase gene polymorphisms with endometrial carcinoma: a preliminary study

Öztürk¹,

Dıkensoy²,

Balat³

et al. 2011

J Turkish German Gynecol Assoc

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Objective: To investigate the relationship between specific endothelial nitric oxide synthase (eNOS) gene polymorphisms and endometrial cancer (ECa). Material and Methods:The study group consisted of 89 patients histologically diagnosed with the endometrioid type of endometrial carcinoma. The control group consisted of 60 randomly selected individuals who had undergone total hysterectomy. Genomic DNA was isolated from paraffin-embedded endometrial tissues. We investigated the G894T polymorphisms (G894T) and variable number tandem repeats polymorphisms in intron 4 (VNTR intron 4) in the eNOS gene by using polymerase chain reaction (PCR) and/or restriction fragment length polymorphism (RFLP). The genotype distributions and allele frequencies of the two groups were compared. Results: Analysis of the VNTR intron 4 polymorphisms in eNOS generevealed that the frequency of the AA genotype was significantly higher in the control group, whereas the frequency of the BB genotype was significantly higher in the ECa group. Analysis of the G894T polymorphisms in eNOS gene revealed a significantly higher frequency of the GG genotype in the control group but a significantly higher frequency of the TT genotype in the endometrial cancer group. Key words: eNOS gene polymorphisms, endometrial carcinoma Received: 21 August, 2011 Accepted: 11 September, 2011 Amaç: Endometrium kanseri ile Endotelyal Nitrik Oksit Sentetaz (eNOS) gen polimorfizmi arasındaki ilişkinin ortaya konulması. Conclusion: Gereç ve Yöntemler:Araştırmaya endometrioid tip endometrial karsinom tanısı almış 89 hasta çalışma grubu olarak, diğer benign sebeplerle total histerektomi uygulanmış 60 hasta kontrol grubu olarak dahil edilmiştir. Genomik DNA endometrial dokuların parafin bloklarından elde edilmiştir. Bu çalışmada eNOS geninin G894T polimorfizmleri ve intron 4'deki değişken tekrarlayan dizi polimorfizmleri (VNTR intron 4) polimeraz zincir reaksiyonu (PCR) ve/veya enzim kesimi (RFLP) ile değerlendirilmiştir.Bulgular: eNOS geninin VNTR intron 4 gen polimorfizmi değerlen-dirildiğinde AA genotip sıklığı kontrol grubunda istatistiksel olarak anlamlı ölçüde yüksek saptanırken, BB genotip sıklığı endometrial kanser grubunda yüksek olarak izlenmiştir. eNOS geninin G894T polimorfizminde ise GG genotip sıklığı kontrol grubunda yüksek izlenirken TT genotip sıklığı hasta grubunda istatistiksel olarak anlamlı ölçüde yüksek olarak saptanmıştır.

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The effect of cell type on surgico-pathologic risk factors in endometrial cancer

Abstract: Aggressive cell types significantly increase the adnexial and lymph node metastasis in endometrial cancer.

Cited by 3 publications

References 25 publications

A model for predicting extrauterine tumor spread in patients with endometrial cancer

A model for predicting extrauterine tumor spread in patients with endometrial cancer

Analysis of mixed type endometrial carcinoma

Association of endothelial nitric oxide synthase gene polymorphisms with endometrial carcinoma: a preliminary study

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