The Effect of Cellular Proliferative Activity on Recurrence and Local Tumour Extent of Localized Giant Cell Tumour of Tendon Sheath

Kitagawa, Yasuyuki; Ito, Hiromoto; Yokoyama, Munehiro; Sawaizumi, Takuya; Maeda, Shin

doi:10.1016/j.jhsb.2004.06.012

Cited by 26 publications

(50 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, Kitagawa et al [8] did not support this theory. The authors advocated that bone involvement in patients with localised GCTTS was due to simple erosion, caused by the pressure effect of the tumour, and was not a true invasion.…”

Section: Discussionmentioning

confidence: 95%

See 1 more Smart Citation

Giant Cell Tumour of Tendon Sheath of the Digits. A Systematic Review

Fotiadis

Papadopoulos

Svarnas

et al. 2011

Hand (New York, N,Y.)

View full text Add to dashboard Cite

Background We reviewed the literature to evaluate the demographic, clinical and histological profile of giant cell tumour of tendon sheath of the digits (GCTTSD). The overall recurrence rate and the factors affecting tumour recurrence were also assessed. Methods We searched for published articles regarding the GCTTSD in the English literature the last 30 years using the PubMed search engine. All retrieved papers were analysed and their reference lists were also screened if relevant. Clinical studies with less than five patients and follow-up less than 2 years were excluded from further evaluation. For each report, information was gathered related to trial characteristics and study population. Location and multicentricity of lesions, kind and severity of symptoms, type of applied treatment modality and histopathological features of the excised tumours were additionally recorded. A meta-analysis for estimating the pooled recurrence rate after surgical excision was also conducted. Statistical significance was assumed for p ≤0.05. Results We found 21 studies with histological confirmation of GCTTS. However, only 10 studies including 605 patients were reviewed according to selection criteria (average follow-up 36.7 to 79 months). The male-to-female ratio was 1:1.47 (p < 0.005) and the mean age ranged from 32 to 51 years. Pain or sensory disturbances reported only in 15.7% and 4.57% of cases, respectively. A definite history of trauma recorded in 5% of lesions. The most frequent tumour location was the index finger (29.7%). In total, 14.8% of patients had tumour recurrence. Type I tumours (single lesions) were more frequently detected (78.7%) than type II tumours (two or more distinct tumours that were not joined together) (21.3%) but the latter were associated with a higher recurrence rate (p < 0.001). Study design also affected the possibility of recurrence as it was lower in prospective studies compared to retrospective studies (p = 0.003). Even though bone erosion was detected in 28.39%, recurrence was not more common in this group. In addition, recurrence was not significantly associated with a specific finger or phalanx. Conclusions Intrinsic biology of the tumour seems to play a more fundamental role in recurrence than tumour location or local invasiveness. More prospective welldesigned studies including a large number of cases are necessary to identify tumours prone to recurrence and determine the proper treatment protocol for each individual patient.

show abstract

Section: Discussionmentioning

confidence: 95%

“…In total, 14.8% of patients had tumour recurrence (83/559 patients) [1,5,6,8,9,15,18,20,23]. Fourteen patients where local irradiation was applied did not experience a tumour recurrence but due to the small number of cases this was not statistically significant [9].…”

Section: Resultsmentioning

confidence: 99%

Giant Cell Tumour of Tendon Sheath of the Digits. A Systematic Review

Fotiadis

Papadopoulos

Svarnas

et al. 2011

Hand (New York, N,Y.)

View full text Add to dashboard Cite

show abstract

“…Reilly et al (1999) and Grover et al (1998) noticed that bone erosion, as confirmed in plain X-rays, might be a reason for recurrence (8,27). However, Kitagawa (2004) did not support this theory, he advocated the bone involvement was due to simple erosion, caused by the pressure effect of the tumor, and was not a true invasion (11). Lowyck (2006) did not find significant correlation of recurrence with pressure erosions, or degenerative joint disease, neither with the location at the distal interphalangeal joint (28).…”

Section: Discussionmentioning

confidence: 98%

Giant cell tumor of tendon sheath: study of 64 cases and review of literature

Grazia¹,

Succi²,

Fragetta³

et al. 2013

G Chir

View full text Add to dashboard Cite

Giant cell tumor of the tendon sheath (GCTTS) is the second most common tumor of the hand after ganglion cysts (1,2). It is a slowly growing, usually painless benign lesion of soft tissues. The tumor affects individuals between the age of 30 and 50 years old and is found more often in women than men (3-6). Despite its benign character, local recurrence after excision has been reported in up to 45% of cases (7); there isn't still a defined treatment protocol and local excision with or without radiotherapy is the treatment of choice to date (1,2,7-13).We made a retrospective study of literature of the last 15 years and evaluated the demographic, clinical and histological aspects of the GCTTS of the hand and compared the results with our experience in a series of 64 cases from 2000 to 2012 to assess the factors that mostly contribute to incidence and recurrence of this tumor. Patients and methodsWe searched for published articles regarding the GCTTS from 1998 using the PubMed search engine. The keywords used were as follows: "giant cell tumor, tumor tendon, hand tumor"; all retrieved papers were analysed and their reference list were also screened if relevant. For each report, information was gathered on characteristics of the trial and study population, location and multicentricity of lesion, kind and severity of symptoms. We also recorded the applied treatment modality, histopathological examination of the excised tumor and recurrence rate.A retrospective study was conducted in our Department of Plastic and Reconstructive Surgery and all data were collected from medical records of 64 GCTTS patients within this Department from 2000 to 2012. Medical record included the age, gender, tumor location, presentation and size, clinical features, treatment modality, histopathological report and neurovascular or tendon involvement.All cases were operated under tourniquet control, using a magnifying loupe. Special care was taken to excise the tumor in total, retaining the capsule, if present, with margin of normal tissue. The operating field is searched for presence of satellite lesions.The histopathological diagnosis and immunohistochemical studies were conducted by the Department of Pathology within the same Hospital. Follow-up ranged from 2-153 months.

show abstract

“…1 The proliferative activity in localized nodular form of GCTTS is not related to its high recurrence rate and local aggressiveness. 12 Because of the extreme rarity of the metastasizing form of GCTTS, it is justifiable to adopt a conservative approach when interpreting these atypical features.…”

Section: Discussionmentioning

confidence: 99%