2023
DOI: 10.3389/fncel.2023.1131168
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The effect of cerium dioxide nanoparticles on the viability of hippocampal neurons in Alzheimer’s disease modeling

Abstract: The possibilities of using nanoparticle materials based on cerium dioxide (CNPs) are exciting since they are low toxic and have specific redox, antiradical properties. It can be supposed that CNPs’ biomedical use is also relevant in neurodegenerative diseases, especially Alzheimer’s disease (AD). AD is known as the pathologies leading to progressive dementia in the elderly. The factor that provokes nerve cell death and cognitive impairment in AD is the pathological accumulation of beta-amyloid peptide (Aβ) in … Show more

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Cited by 7 publications
(2 citation statements)
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“…There are contradictory reports on whether CeO 2 NPs may act as an oxidant causing toxicity or as an antioxidant, being able to scavenge free radicals and protect the cells from oxidative damage. CeO 2 NPs displayed low toxicity without increasing the number of necrotic cells compared to the control group, which can significantly inhibit the number of dead hippocampal neurons [21]. In tau-induced Drosophila models of Alzheimer's disease, CeO 2 NPs were reducing the levels of tau at the transcriptional level.…”
Section: Introductionmentioning
confidence: 94%
“…There are contradictory reports on whether CeO 2 NPs may act as an oxidant causing toxicity or as an antioxidant, being able to scavenge free radicals and protect the cells from oxidative damage. CeO 2 NPs displayed low toxicity without increasing the number of necrotic cells compared to the control group, which can significantly inhibit the number of dead hippocampal neurons [21]. In tau-induced Drosophila models of Alzheimer's disease, CeO 2 NPs were reducing the levels of tau at the transcriptional level.…”
Section: Introductionmentioning
confidence: 94%
“…Hippocampal cultures are widely used to study the mechanisms and strategies for treating the central nervous system's disorders, including AD (Calvo-Rodriguez et al, 2019;Coelho et al, 2019;Hanzha et al, 2023). In our studies, the AD model was obtained by 24-h incubation of hippocampal culture neurons with 2 μM Aβ1-42 (Sigma-Aldrich, St. Louis, MO, United States).…”
Section: Introductionmentioning
confidence: 99%