The Effect of Chronic Administration of a Synthetic LH‐RH Analogue Intranasally in Cryptorchid Boys

Abstract

Eighteen boys with either unilateral or bilateral cryptorchidism were treated with a synthetic LH-RH analogue ("D-Leu 6, Des-Gly-10 LH-RH ethylamide") intranasally. The peptide was dissolved in aqueous solution (25 micrograms in 0,2 ml) and administered in the form of nasal drops. The patients were divided in two groups: in group A, 50 micrograms of the synthetic LH-RH analogue were administered intranasally every 48 h for 36 days; in group B same dose was given every 24 h. Additionally, in 4 cases a LH-RH test prior the trial was performed with the same peptide. The nasal administration resulted in a fivefold increase of LH and of FSH plasma concentration in 30 min and in 60 min, respectively. The endocrine profiles for T, LH and FSH were studied in each group over the treatment period and in group B (same dose was given every 24 h) a significant decrease of the LH and FSH plasma levels could be found. The clinical effect of treatment was same in the both groups. In the whole material 44% had either unilateral or bilateral descent of the testis after the therapy.

Efficacy and safety of hormonal treatment of cryptorchidism: current state of the art

“…Great variation of the effects of hormonal treatment have been reported, with success rates from 0% to 55% and 9% to 78% with hCG and GnRH, respectively, depending on inclusion of different proportions of boys with retractile testes (3). Cryptorchidism has also been treated with human menopausal gonadotropin (4), synthetic analogues of GnRH (5–7) and combined hormonal therapy (4,8–12).…”

Clinical Effect of Cryptocur by Undescended Testicles/Der klinische Effekt von Cryptocur (LH-RH-Spray) bei Behandlung des Hodenhochstandes

“…Its use in Hungary is limited by the expences and difficulties in commercial availability. Literature data and our own experience show that besides its advantageous properties this treatment modality reaches or even depasses the effectiveness of other conservative drug regimens (Bulyovszky and Racz -1982;Molnar -1971;Papp -1985) HCG and LH-RH treatment may not only the combined but following unsuccessful LH-RH therapy an adjuvant Choriogonin cure is strongly advocated (Hadziselimovic -1983). When this latter remains without effect LH-RH treatment should be repeated.…”

“…First a younger age is chosen for therapeutic actions that is less than two years of age instead of puberty (Bartsch and Frick -1974). Secondly conservative treatment was completed by the use of drugs containing LH-RH (Bartsch and Frick -1974;Frick et al -1980;Happ et al -1975;Papp -1988;Schreiber et al -1986). Nowadays infertility due to cryptor-chidism can be prevented in many cases with adequate therapy.…”

“…Later mainly due to the treatment modality which was developed during the last decade and is routinely used throughout Europe meant a new trend in medical therapy. Because of its evident advantages it became one of the main elements of therapeutic schemes (Hadziselimovic -1983;Weissbach and Struth -1983). In our country Vegh (1987) gained favourable experience with the application of this product.…”