The effect of combined functional training on BDNF, IGF-1, and their association with health-related fitness in the multiple sclerosis women

Abbaspoor, Elnaz; Zolfaghari, Mehdi; Ahmadi, Babak; Khodaei, Kazem

doi:10.1016/j.ghir.2020.101320

Cited by 24 publications

(39 citation statements)

References 38 publications

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“…1. Eighteen studies (34.6%) involved only aerobic exercises [5,[29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45], 16 studies (30.8%) involved only resistance exercise [46][47][48][49][50][51][52][53][54][55][56][57][58][59][60][61], and 18 studies (34.6%) involved a combination of aerobic and resistance exercise [62][63][64][65][66][67][68][69][70][71][72][73][74][75][76][77]…”

Section: Resultsmentioning

confidence: 99%

“…1 . Eighteen studies (34.6%) involved only aerobic exercises [ 5 , 29 – 45 ], 16 studies (30.8%) involved only resistance exercise [ 46 – 61 ], and 18 studies (34.6%) involved a combination of aerobic and resistance exercise [ 62 – 79 ]. Of these, ten studies were multi-armed trials that evaluated different rates of aerobic and resistance exercise [ 75 ], various aerobic exercise protocols [ 5 , 79 ] or different community exercise interventions [ 67 ], or compared aerobic and/or resistance exercise to an ineligible intervention arm (such as yoga) [ 29 , 38 , 40 , 48 , 49 , 54 , 67 ].…”

Section: Resultsmentioning

confidence: 99%

“… ? None Moradi et al (2015) [ 60 ] + + + + NR NR ↑ Estimated 1RM strength (seated rowing, chest press, leg extension, leg press), functional capacity (3-min step test, TUG); ↓ EDSS Aerobic and resistance exercise Abbaspoor et al (2020) [ 62 ] + + ? + NR NR ↑ Handgrip strength, IGF-1, walking speed Aidar et al (2017) [ 63 ] + NR ?…”

Section: Resultsmentioning

confidence: 99%

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Systematic Review of Exercise Studies in Persons with Multiple Sclerosis: Exploring the Quality of Interventions According to the Principles of Exercise Training

et al. 2021

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Introduction: The objective of this systematic review is to explore the application and reporting of (i) the principles of exercise training in exercise trials, (ii) the components of exercise prescription, and (iii) the adherence towards the prescribed programmes in randomised controlled trials (RCTs) in persons with multiple sclerosis (pwMS). Methods:The MEDLINE, CINAHL, SPORTDiscus, PubMed and Embase electronic databases were searched from 1 January 2000 to 16 October 2020. RCTs comprising at least 3 weeks of aerobic and/or resistance exercise intervention in pwMS that reported at least one physiological outcome and were published in peerreviewed journals were eligible for inclusion. Results: Out of 52 RCTs included in this review, 58 intervention arms were examined. None applied more than four principles of exercise training. Specificity was addressed by 85%, progression by 33%, overload by 59%, initial values by 26%, reversibility by 0% and diminishing returns by 2% of trials. Fifty-two percent of trials reported all components of exercise prescription, and 3% of trials reported the level of adherence to the prescribed exercise. Marit L. Schlagheck and Niklas Joisten contributed equally and share first authorship. Annette Rademacher and Philipp Zimmer contributed equally and share last authorship.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Systematic Review of Exercise Studies in Persons with Multiple Sclerosis: Exploring the Quality of Interventions According to the Principles of Exercise Training

et al. 2021

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“…In addition, IGF-I, as an effector of Th17/ Treg cell balance, induced proinflammatory responses in EAE (13). Therefore, IGF-I is not only considered as a neuroprotective agent but is also discussed concerning health-related fitness in MS patients after aerobic training (19). Accordingly, substantial reasons argue for the assessment of the IGF system in MS patients, both in CSF and in the circulation.…”

Section: Discussionmentioning

confidence: 99%

“…This effect was also significant in the male subgroup. A previous study showed that after aerobic training, the serum concentrations of IGF-I in MS patients are significantly correlated with muscle strength (left and righthand strength, quadriceps strength) and walking speed (19). Low levels of IGF-I in the circulation were further associated with fatigue and cognitive impairment in MS patients (24).…”

Section: Effects Of Triamcinolone Acetonide Applicationmentioning

confidence: 96%

Reduced Fragmentation of IGFBP-2 and IGFBP-3 as a Potential Mechanism for Decreased Ratio of IGF-II to IGFBPs in Cerebrospinal Fluid in Response to Repeated Intrathecal Administration of Triamcinolone Acetonide in Patients With Multiple Sclerosis

Hoeflich

Fitzner²,

Walz

et al. 2021

Front. Endocrinol.

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Multiple sclerosis (MS) is a chronic autoimmune disease of the brain and spinal cord causing a wide range of symptoms such as impaired walking capability, spasticity, fatigue, and pain. The insulin-like growth factor (IGF) system has regulatory functions for the induction of inflammatory pathways in experimental encephalomyelitis. We have therefore assessed expression and regulation of the IGF system on the level of IGFs and IGFBPs in serum and cerebrospinal fluid (CSF) in the course of four repeated triamcinolone acetonide (TCA) administrations in two female and four male MS patients. Sample series of 20 treatment cycles were analyzed. IGF-I and IGF-II were quantified by ELISAs, and IGFBPs were analyzed by quantitative Western ligand (qWLB) and Western immunoblotting (WIB) in order to differentiate intact and fragmented IGFBPs. The ratios of fragmented to intact IGFBP-2 and -3 were calculated in serum and CSF. Finally, the ratios of IGF-I and IGF-II to the total IGF-binding activity, quantified by qWLB, were determined as an indicator of IGF-related bioactivity. After the fourth TCA administration, the average level of IGF-I was increased in serum (p < 0.001). The increase of IGF-I concentrations in serum resulted in an increased ratio of IGF-I to IGFBPs in the circulation. By contrast in CSF, fragmentation of IGFBP-2 and IGFBP-3 and the ratio of IGF-II to intact IGFBPs were decreased at the fourth TCA administration (p < 0.01). Furthermore, reduced fragmentation of IGFBP-3 in CSF was accompanied by increased concentrations of intact IGFBP-3 (p < 0.001). We conclude that reduced fragmentation of IGFBPs and concomitant reduction of IGF-II to IGFBP ratios indicate regulation of bioactivity of IGF-II in CSF during repeated intrathecal TCA administration in MS patients.

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Elastic Band Training on Body Composition in Healthy Middle-Aged and Elderly People: A Meta-Analysis

Dagang,

Ghani

2024

Lecture Notes in Bioengineering

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The effect of combined functional training on BDNF, IGF-1, and their association with health-related fitness in the multiple sclerosis women

Cited by 24 publications

References 38 publications

Systematic Review of Exercise Studies in Persons with Multiple Sclerosis: Exploring the Quality of Interventions According to the Principles of Exercise Training

Systematic Review of Exercise Studies in Persons with Multiple Sclerosis: Exploring the Quality of Interventions According to the Principles of Exercise Training

Reduced Fragmentation of IGFBP-2 and IGFBP-3 as a Potential Mechanism for Decreased Ratio of IGF-II to IGFBPs in Cerebrospinal Fluid in Response to Repeated Intrathecal Administration of Triamcinolone Acetonide in Patients With Multiple Sclerosis

Elastic Band Training on Body Composition in Healthy Middle-Aged and Elderly People: A Meta-Analysis

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