The Effect of Continuous Subcutaneous Insulin Infusion Treatment, Insulin Analog, and Human Insulin of Children With Diabetes

Abstract

Abstract:The aim of this study was to evaluate the cost-effectiveness of continuous subcutaneous insulin infusion (CSII) to multiple daily insulin injection (MDI) either with analogues or with human insulin, based on the achieved therapeutic results such as changes in glycated hemoglobin level (HbA1c) in the various therapies. The study was performed with children with type-1 diabetes in Bulgaria. The objective of this study was to serve for the Bulgarian National Health Fund (NHIF). Methods:A combined retrospective and prospective study was performed at the Endocrinology diabetes and genetic diseases clinic. 51 children with type-1 diabetes were observed for 7 months diveded into three group: Group 1 -on continuous subcutaneous insulin infusion (CSII), Group 2 -on multiple daily insulin analogues injections (MDI), and Group 3 -on human insulin (HI). Patient demographic data, age, sex, weight, duration of disease, HbA1c -values before the start of the study and after the end of the observation and type of treatment (CSII; MDI or HI) were observed. Cost-effectiveness, sensitivity, and statistical analyses are applied to studied long-term therapeutic results.