The Effect of Copper and Magnesium Sulfate on Inflammation*

Stone, Orvitte J.; Willis, Carolyn J.

doi:10.1111/j.1365-4362.1969.tb05325.x

Cited by 5 publications

(2 citation statements)

References 7 publications

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“…Magnesium deficiency is associated with increased levels of inflammatory cytokines such as IL-6, IL-1β and TNFα 31, 32 . However, despite MgSO 4 being studied as an inflammatory modulator for decades 33, 34 , its mechanism of action in obstetrical use is still unclear. Since chorioamnionitis is a major risk factor for preterm birth, the objective of this study was to determine whether MgSO 4 could modulate FM inflammation in response to infectious products, and whether timing of MgSO 4 exposure was important using an in vitro human FM explant system.…”

Section: Discussionmentioning

confidence: 99%

Magnesium sulfate differentially modulates fetal membrane inflammation in a time‐dependent manner

Cross

Nelson

Potter

et al. 2018

American J Rep Immunol

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Section: Discussionmentioning

confidence: 99%

Magnesium sulfate differentially modulates fetal membrane inflammation in a time‐dependent manner

Cross

Nelson

Potter

et al. 2018

American J Rep Immunol

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“…They could also influence ground substance viscosity. I have shown in experimental models that both mercury and iodide increase the movement of polymorphonuclear leukocytes into injured or inflamed areas 15,16 . This would explain the reactions at a tattoo site or in an iododerma.…”

Section: Mechanismsmentioning

confidence: 97%

Hyperinflammatory Proliferative (Blastotnycosis‐like) Pyodermas: Review, Mechanisms, and Therapy

Stone

1986

The Journal of Dermatologic Surgery and Oncology

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Some sites of chronic localized infection have a vigorous granulocytic inflammatory response and develop marked tissue proliferation. This is most common in patients with poor nutrition, halogen ingestion or foreign bodies. The granulocytes release connective tissue-activating peptides which cause fibroblast proliferation and ground substance formation. The dermal papillae enlarge and support a larger germinative cell volume, producing pseudoepitheliomatous hyperplasia. Hypertrophic granulation tissue or "proud flesh" appears to be a similar phenomenon without the epithelial component. In a milder physiologic range this phenomenon probably accounts for the term "laudable pus."

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