The effect of cortisone on bronchial asthma and hay fever occurring in subjects sensitive to ragweed pollen

Carryer, Haddon M.; Koelsche, Giles A.; Prickman, Louis E.; Maytum, Charles K.; Lake, Clifford F.; Williams, Henry L.

doi:10.1016/0021-8707(50)90059-1

Cited by 92 publications

(31 citation statements)

References 7 publications

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“…Glucocorticoids have been known for a long time to be the most effective treatment for chronic asthma [20]. Glu cocorticoids inhibit the recruitment and activation of eosinophils, thereby blocking the development of the LAR [21,22], Accumulating evidence suggests that LAR is a consequence of eosinophilic inflammation in the lung [6,7,21] and highly dependent upon T cells and T cell cytokine, IL-5 [4,8], Our finding that glucocorticoids sup press IL-5 production may suggest the sequelae that inhi bition of IL-5 production leads to reduced eosinophilic inflammation.…”

Section: Resultsmentioning

confidence: 99%

Regulation of lnterleukin-5 Production by Peripheral Blood Mononuclear Cells from Atopic Patients with FK506, Cyclosporin A and Glucocorticoid

Mori

Suko

Nishizaki

et al. 1994

Int Arch Allergy Immunol

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Upon stimulation with phorbol ester and ionomycin, peripheral blood mononuclear cells (PBMC) of atopic patients with moderate eosinophilia produced significantly higher amounts of IL-5 compared to that of normal subjects. This finding renders further support to the notion that T cell-eosinophilic inflammation plays a central role in allergic disorders. IL·5 induction in vitro was completely inhibited by immunosuppressant FK506, cyclosporin A and dexamethasone. FK506 applied in vivo effectively suppressed clinical symptoms of atopic dermatitis and IL-5 production of PBMC. FK506 and cyclosporin A may become a better therapeutic modality against allergic diseases.

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Section: Resultsmentioning

confidence: 99%

Regulation of lnterleukin-5 Production by Peripheral Blood Mononuclear Cells from Atopic Patients with FK506, Cyclosporin A and Glucocorticoid

Mori

Suko

Nishizaki

et al. 1994

Int Arch Allergy Immunol

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“…Since their introduction in 1950, 1 glucocorticoids have remained the most consistently effective therapy for asthma. Glucocorticoids potently alter inflammation 2,3 ;…”

mentioning

confidence: 99%

Treatment of asthma with nebulized lidocaine: A randomized, placebo-controlled study☆

Hunt

Frigas

Butterfield

et al. 2004

Journal of Allergy and Clinical Immunology

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“…The beneficial effects of glucocorticoids in asthmatic patients were first described in 1950 [8]. Many studies have focused on the therapeutic potential of glucocorticoids.…”

Section: Introductionmentioning

confidence: 99%

In Silico Studies of the Secondary Metabolites of Solanum Torvum Sw. For Their Antiasthmatic Activity

Soorya

Kumar

et al. 2017

Int J Curr Pharm Sci

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Objective: Solanum torvum Sw., Family: Solanaceae, commonly known as Turkey Berry is used by the traditional tribes for the treatment of cold, cough, tuberculosis, hepatotoxicity, cancer, etc. The action of the plant towards the treatment of these diseases has been proven except for asthma. The present study is to prove the antiasthmatic activity of methanolic extract and the secondary metabolites of Solanum torvum Sw using in silico docking studies in compare to reference standard Dexamethasone, a synthetic cortisone derivative. Methods:The GC-MS analysis of the dried methanolic extract of the dried fruits of Solanum torvum Sw. and the total saponin fraction has been carried out to know the important moieties that are responsible for the antiasthmatic activity. Results:The results from the docking studies showed that the compounds Cholesta-5,7,9-(11)-trien-3-ol,4,4-dimethyl, (3á); Lanosta-7,9-(11),20-triene-3α, 18-diol, diacetate and Cholestan-26-oic acid,3,7,12,24-tetrakis (acetyloxy), methyl ester, (3à,5á,7à,12à) were found to have significant scores of-6.8,-6.9 and-6.9 respectively towards Glucocorticoid receptor protein (Gr), (PDB id: 4UDC) which is very similar to the affinity of the standard (-7.1). These compounds passed the drug-likeness test. A modification in the structure can be brought, which makes the compounds more potent. The compounds 9, 12-Octadecadienoic acid, ethyl ester; Hexadecanoic acid, ethyl ester; 9-Octadecenoic acid (Z), methyl ester; Oxacycloheptadec-8-en-2-one, (8Z) have passed the Blood Brain Barrier (BBB) filter of the drug-likeness test. Conclusion:The antiasthmatic activity of the drug may be due to the similarity with the structure of Dexamethasone. Further research can be carried out in order to improve the clinical significance of these extracts and its metabolites.

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The effect of cortisone on bronchial asthma and hay fever occurring in subjects sensitive to ragweed pollen

Cited by 92 publications

References 7 publications

Regulation of lnterleukin-5 Production by Peripheral Blood Mononuclear Cells from Atopic Patients with FK506, Cyclosporin A and Glucocorticoid

Regulation of lnterleukin-5 Production by Peripheral Blood Mononuclear Cells from Atopic Patients with FK506, Cyclosporin A and Glucocorticoid

Treatment of asthma with nebulized lidocaine: A randomized, placebo-controlled study☆

In Silico Studies of the Secondary Metabolites of Solanum Torvum Sw. For Their Antiasthmatic Activity

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