The effect of date palm fruit (Phoenix dactylifera L.) on the hormone 17-ß-estradiol in 7,12-dimethylbenz(a)anthracene-induced mammary cancer in rats

Al-Sayyed, Hiba F.; Takruri, Hamed R.; Shomaf, Maha; Al-Saleh, AbdulRahman

doi:10.3233/mnm-140001

Cited by 13 publications

(7 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Al-Sayyed et al reported the potential cancer preventive effects of date fruit. They found that increase consumption of dried date fruit reduced significantly the incidence rate of mammary cancer, palpable tumor multiplicity, tumor size and weight compared to the positive control group (Al-Sayyed et al, 2014 ). Eid et al studied the whole date fruit extract and its polyphenol-rich extract, both extracts were prepared from methanol/water (4:1, v/v) containing 10% of 1 molar sodium fluoride (NaF) solution, found to inhibit Caco-2 cell growth, indicating that both were capable of probably acting as anti-proliferative agents in-vitro .…”

Section: Therapeutic Optionsmentioning

confidence: 98%

Date Palm Tree (Phoenix dactylifera L.): Natural Products and Therapeutic Options

et al. 2017

View full text Add to dashboard Cite

Many plants, including some of the commonly consumed herbs and spices in our daily food, can be safely and effectively used to prevent and/or treat some health concerns. For example, caffeine the active ingredient found in coffee beans (Coffea), shows biological activity in the treatment of the central nervous system (CNS) disorders, indole-3-carbinol, and 3,3′-diindolylmethane are both broccoli (Brassica oleracea) derived phytochemicals with potential anti-cancer activity, and resveratrol, isolated from grape (Vitis vinifera), is reported to extend lifespan and provide cardio-neuro-protective, anti-diabetic, and anti-cancer effects. Date palm fruits possess high nutritional and therapeutic value with significant antioxidant, antibacterial, antifungal, and anti-proliferative properties. This review focuses on the date fruit extracts and their benefits in individual health promoting conditions and highlights their applications as useful to the pharmaceutical and nutraceutical industries in the development of natural compound-based industrial products.

show abstract

Section: Therapeutic Optionsmentioning

confidence: 98%

Date Palm Tree (Phoenix dactylifera L.): Natural Products and Therapeutic Options

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Although, [45] showed that extractable polyphenols (EPP) from Ajwa date fruits were cytotoxic against other cancer cell lines such as hepatocellular carcinoma (HCT-116). Al-Sayyed, et al [46] found that increasing consumption of dried date fruit reduced significantly the incidence rate of mammary cancer, palpable tumour multiplicity, tumour size and weight compared to the positive control group. In another study, Eid, et al [47] studied the effect of the whole date fruit extract and its polyphenol-rich extract, which were prepared from methanol/water (4:1, v/v) containing 10% of 1 molar sodium fluoride (NaF) solution, on the Caco-2 cell lines.…”

Section: Evaluation Of Solvent/sample Ratiomentioning

confidence: 99%

Effects of Time, Temperature, and Solvent Ratio on the Extraction of Non-Extractable Polyphenols with Anticancer Activity of Barhi Date Palm Kernels Extracts Using Response Surface Methodology

Mahmud¹,

Mirghani²,

Yusof³

et al. 2019

Preprint

View full text Add to dashboard Cite

Dietary polyphenols exist in two forms; extractable polyphenols (EPP) or compounds solubilised by aqueous/organic solvents, and non-extractable polyphenols (NEPP) or compounds remain in the corresponding residues after the extraction. At present, most researchers focus on EEP fractions, while NEPP is neglected. Thus, this study aimed to release NEPP from the remaining powder residue of Barhi date palm kernels (BDPK) with acid hydrolysis. The related extraction conditions were determined and optimised using response surface methodology (RSM) for maximisation of NEPP with highest cytotoxic and antioxidant activities. The face-centred central composite design (FCCCD) was used to establish treatments based on three independent variables, namely; extraction temperature, time, and solvent/sample ratio. Under the optimal conditions, the experimental values for DPPH radical-scavenging capacity of NEPP (IC50=57.52µg/mL), and cytotoxicity of NEPP against A549 and HT29 cells were IC50=17.4 µg/mL and 31.4µg/mL, respectively. The experimental values were in agreement with those predicted by RSM models, confirming the suitability of the model employed and the success of RSM for optimisation of the extraction conditions for NEPP from BDPK. These results indicate that NEPP from industrial date fruit waste could be a promising candidate as natural antioxidants with significant antiproliferation effect against A549 and HT29 cancer cells in-vitro.

show abstract

“…Also, the dates quercetin and kaempferol showed high cytotoxic activity against pc3 cells ( 69 , 70 ). Another in vitro study was conducted by Al-Sayyed et al ( 71 ) and reported that Barhi date palm fruit prevents 7,12-Dimethylbenzathracene (DMBA)-induced mammary cancer. Its outcomes can be correlated with the other two drugs, i.e., tamoxifen and 17-β-estradiol.…”

Section: Discussionmentioning

confidence: 99%

Potential bioactivity of Phoenix dactylifera fruits, leaves, and seeds against prostate and pancreatic cancer cells

et al. 2022

View full text Add to dashboard Cite

The use of functional foods’ phytochemicals in the chemoprevention of different cancer diseases has become one of the hot scientific areas in the clinical nutrition field. For instance, the Khalas palm cultivar (KPC; Phoenix dactylifera) is one of the natural sustainable resources that have high bioactivity and functionality. This study aimed to investigate the antiproliferative activity and mode of action of KPC’s different parts on prostate (Pc3) and pancreatic (panc1) cancer cells at a molecular level. In the methods, KPC’s leaves, seeds, and fruits’ chemical composition and phytochemical analysis were analyzed. Also, the cytotoxic effects of each extract were assessed against pc3 and panc1 cell lines. Besides, induction of apoptosis, cell cycle analysis, and gene expression of both Cap3 and Cap9 were studied. The obtained results indicated that KPC leaves extract exhibited the highest significant (P < 0.01) anti-proliferation activity against the utilized cancer cell lines compared to fruits and seeds extracts. Also, there were significant (P < 0.05) differences in the phenolic contents, flavonoid of compounds, and antioxidant power of the leaves when compared to the seeds and fruits. Additionally, the highest cytotoxic effect (lowest IC50) was recorded with leave extract than seeds and fruits. Meanwhile, the seeds extract induced (P < 0.05) the apoptosis and arrested cells in the G2/M phase as well as up-regulated the gene expression of the apoptotic-related genes (Casp3 and Casp9) compared to the control group. In conclusion, this study showed that the presence of bioactive components in the KPC different parts extracts have the significant ability to induce the apoptotic pathway that could down-regulate the proliferation of prostate (pc3) and pancreatic (panc1) cancer cells. The pathway mechanism of action was induced by the phytol molecule presented in its leaves extract.

show abstract

The effect of date palm fruit (Phoenix dactylifera L.) on the hormone 17-ß-estradiol in 7,12-dimethylbenz(a)anthracene-induced mammary cancer in rats

Cited by 13 publications

References 13 publications

Date Palm Tree (Phoenix dactylifera L.): Natural Products and Therapeutic Options

Date Palm Tree (Phoenix dactylifera L.): Natural Products and Therapeutic Options

Effects of Time, Temperature, and Solvent Ratio on the Extraction of Non-Extractable Polyphenols with Anticancer Activity of Barhi Date Palm Kernels Extracts Using Response Surface Methodology

Potential bioactivity of Phoenix dactylifera fruits, leaves, and seeds against prostate and pancreatic cancer cells

Contact Info

Product

Resources

About