1967
DOI: 10.1021/bi00863a017
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The Effect of Development and Hydrocortisone on Tryptophan Oxygenase, Formamidase, and Tyrosine Aminotransferase in the Livers of Young Rats*

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1971
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Cited by 61 publications
(26 citation statements)
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“…If our results are divided by the wet wt/dry wt ratio for liver of 3.45 (Woods & Krebs, 1971) this gives a value for pyrrolase activity of 0.5 ,mol kynurenine formed h'1 g-1 liver (wet wt) which is in excellent agreement with the results of Baughman & Franz (1971). Franz & Knox (1967) have discussed the criteria for definite enzymic activity and concluded that anything less than 1.0 ,imol kynurenine formed h-1 g-1 liver (wet wt)…”
Section: Discussionsupporting
confidence: 80%
“…If our results are divided by the wet wt/dry wt ratio for liver of 3.45 (Woods & Krebs, 1971) this gives a value for pyrrolase activity of 0.5 ,mol kynurenine formed h'1 g-1 liver (wet wt) which is in excellent agreement with the results of Baughman & Franz (1971). Franz & Knox (1967) have discussed the criteria for definite enzymic activity and concluded that anything less than 1.0 ,imol kynurenine formed h-1 g-1 liver (wet wt)…”
Section: Discussionsupporting
confidence: 80%
“…The rapid rise in TTA activity in rat liver after birth lias been found by several investigators [2,6,17]. C.reengard and Dewcy [5] suggested that postnatal hypoglycemia stimulates glucagon release, which then induces liver TTA.…”
Section: Discussionmentioning
confidence: 66%
“…Their finding that postnatal injection of glucose decreases the normal increase of TTA activity is in agreement with this proposal. The failure of adreiialectoini/ed newborn rats to undergo the normal postnatal increase in TTA activity, the induction of TTA by administration of hydrocortisone to these animals [17], and, further, the observation by Franz and Knox [2] that administration of hydrocortisone to newborn rats did not elevate TTA activity until after I lie postnatal increase had occurred suggest that glucororlicoids apparently also participate in the immediate postnatal increase of TTA activity.…”
Section: Discussionmentioning
confidence: 99%
“…The protein synthesis was programmed with rat liver poly(A)-containing mRNA, which was prepared by phenol extraction of the liver according to the method of Schutz et al (17,18 10 ,ul of the wheat germ S30, and 12 ,ug of hepatic poly(A)-containing mRNA. Incubations were at 20-210 for 150 min.…”
Section: Methodsmentioning
confidence: 99%
“…One of these enzymes is tryptophan 2,3-dioxygenase [EC 1.13.11.11; L-tryptophan:oxygen 2,3-oxidoreductase (decyclizing)], which is part of a cluster of enzymes that first appears in rat liver at the end of the second postnatal week. It increases to the adult level by 22 days after birth (7)(8)(9)(10)(11)(12)(13)(14). Other studies have shown that the increase in enzyme activity between 15th and 22nd postnatal days results from an increase in its rate of synthesis (14), and in turn, the amount of immunochemically titratable enzyme (11).…”
mentioning
confidence: 99%