The effect of different temporal relationships of 5‐hydroxytryptophan (5‐HTP) and l‐dihydroxyphenylalanine (L‐DOPA) on reproductive and metabolic responses of migratory red‐headed bunting (<i>Emberiza bruniceps</i>)

Chaturvedi, Chandra Mohini; Bhatt, Ramesh Chandra

doi:10.1080/09291019009360033

Cited by 30 publications

(23 citation statements)

References 23 publications

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“…Quail were weighed and divided randomly into three groups (n=8 per group). The specific phase relation of circadian serotonergic and dopaminergic activity was induced as follows according to Chaturvedi and Bhatt (1990): (1) group I (control) received normal saline twice daily for 13 days (because two normal saline injections at either 8-or 12-h intervals had a similar effect, only one control was taken into account); (2) group II (8-h) received 5-HTP at 08:00 h and L-DOPA at 16:00 h, establishing an 8-h relationship between the two injections; and (3) group III (12-h) received 5-HTP at 08:00 h and L-DOPA at 20:00 h, establishing a 12-h relationship.…”

Section: Methodsmentioning

confidence: 99%

“…The length and width of the left and right testes were measured in situ with dial calipers. Testicular volume of both the testis was calculated using Bissonett's formula 4/3πab 2 (where a=½ of the long axis and b=½ of the short axis) and averaged (Chaturvedi and Bhatt, 1990;Chaturvedi et al, 1993). Both the testes were excised and weighed.…”

Section: Testes Fixation and Measurementmentioning

confidence: 99%

“…Accordingly, the serotonin precursor 5-HTP and the dopamine precursor L-DOPA given 8 h apart induce gonadal suppression, and if given 12 h apart, lead to gonadal stimulation, while other relationships (0, 4, 16 and 20 h apart) are found to be ineffective (Chaturvedi et al, , 2006Bhatt and Chaturvedi, 1992). Daily injections of 5-HTP and L-DOPA in specific temporal relation also determine seasonality (reproductive responsiveness to temperature) in the teleost fish Fundulus grandis (Emata et al, 1985), and have also established the reproductive and fattening effect in red-headed bunting (Chaturvedi and Bhatt, 1990). The hypothalamic reproduction regulatory peptides [gonadotropinreleasing hormone (GnRH)-gonadotropin-inhibitory hormone (GnIH) system] and hypophyseal hormones [LH, folliclestimulating hormone (FSH) and prolactin] in combination control and/or regulate steroidogenesis as well as spermatogenesis.…”

Section: Introductionmentioning

confidence: 98%

“…Injections of these precursor drugs, if given at 12-h intervals, stimulated and at 8-h intervals suppressed the gonadal systems in the autumn-breeding sedentary species lal munia, Estrilda amandava (Chaturvedi et al, 1994), and spotted munia, Lonchura punctulata (Chaturvedi and Prasad, 1991;Chaturvedi, 1992, 1998), as well as summer-breeding migratory red-headed bunting, Emberiza bruniceps (Chaturvedi and Bhatt, 1990). In another summer-breeding but non-migratory species, the Indian weaver bird, Ploceus phillipinus, which lacks the characteristic postreproductive photorefractory phase (Thapliyal and Saxena, 1964), daily administration of 5-HTP and L-DOPA at an interval of 12 h induced full breeding condition much in advance of the annual gonadal cycle, coupled with the nuptial plumage [luteinizing hormone (LH) dependent] and black bill (male hormone dependent) (Chaturvedi et al, 1997).…”

Section: Introductionmentioning

confidence: 99%

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Apoptosis-mediated testicular alteration in Japanese quail (Coturnix coturnix japonica) in response to temporal phase relation of serotonergic and dopaminergic oscillations

Banerjee

Tsutsui

Chaturvedi

2016

Journal of Experimental Biology

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Reproductive performance of many avian species, including Japanese quail, is reported to be modulated by specific temporal phase relation of serotonergic and dopaminergic oscillations. Accordingly, it has been shown that the serotonin precursor 5-HTP and the dopamine precursor L-DOPA given 8 h apart induce gonadal suppression and given 12 h apart lead to gonadal stimulation, while other temporal relationships were found to be ineffective. In the present study, we investigated the effects of 8-and 12-h phase relation of neural oscillations on testicular responses including expression of GnRH-I, GnIH, pro-apoptotic proteins ( p53 and Bax), inactive and active executioner caspase-3, and the uncleaved DNA repair enzyme PARP-1. Testicular volume and mass decreased significantly in 8-h quail and increased in 12-h quail compared with controls. Expression of ir-GnIH, p53, Bax and active-caspase-3 increased and that of GnRH-I, pro-caspase-3 and uncleaved PARP-1 decreased in 8-h quail compared with controls. A TUNEL assay also confirmed testicular regression in these quail. Testes of 12-h quail exhibited significantly increased expression of GnRH-I, pro-caspase-3 and uncleaved PARP-1 compared with the control group. Our findings suggest that differential response of avian testes to 8-and 12-h phase relation of serotonergic and dopaminergic neural oscillations may be attributed to autocrine/paracrine action of GnIH expression, which is upregulated in regressed testes, leading to apoptotic changes, and downregulated in developed testes, causing apoptotic inhibition. It is concluded that specific phase relation of neural oscillations may modulate the local testicular GnRH-GnIH system and alter the apoptotic mechanism in quail testes. Moreover, these findings highlight the physiological effects of time-dependent drug delivery, including the specific time intervals between two drugs.

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Section: Methodsmentioning

confidence: 99%

Section: Testes Fixation and Measurementmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

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Apoptosis-mediated testicular alteration in Japanese quail (Coturnix coturnix japonica) in response to temporal phase relation of serotonergic and dopaminergic oscillations

Banerjee

Tsutsui

Chaturvedi

2016

Journal of Experimental Biology

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“…Testicular and ovarian development and fat deposition are stimulated or inhibited after daily injections of 5-HTP and L-DOPA at the interval of 12 or 8 h, respectively, in the whitethroated sparrow Zonotrichia albicollis (Miller and Meier, 1983), Japanese quail C. coturnix japonica (Chaturvedi and Meier, 1988), the migratory red headed bunting, Emberiza bruniceps (Chaturvedi and Bhatt, 1990), non-migratory spotted munia, Lonchura punctulata (Chaturvedi and Prasad, 1991;Prasad et al, 1992), Lal munia Estrilda amandava (Chaturvedi et al, 1994) and Indian weaver bird Ploceus philippinus (Prasad and Chaturvedi, 2006). Injections of 5-HTP and L-DOPA given at different intervals showed marked changes in certain blood and serum constituents (Prasad and Thakur, 2005;, hormonal level and neurosecretory materials of the median eminence (Prasad and Rathore, 2004).…”

Section: Femalementioning

confidence: 99%

Mucuna pruriens seed powder feeding influences reproductive conditions and development in Japanese quail Coturnix coturnix japonica

Prasad

Qureshi

2009

Animal

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This study was designed to test whether Mucuna pruriens, a natural source of L-dihydroxyphenylalanine (L-DOPA, a dopamine precursor) feeding, can influence development and reproductive conditions in the high food value bird, Japanese quail, Coturnix coturnix japonica. Experiments were performed in both male and female Japanese quail. One-week-old quail chicks were divided into three groups of 36 birds each. Group I was provided with normal diet and served as control. Group II was provided with food mixed with L-DOPA (50 mg/15 g food) and Group III was provided with food mixed with M. pruriens seed powder (480 g/kg food). At the age of 3 weeks (when birds were sexually distinguished) Group I was divided into two subgroups IA (male) and IB (female) of six birds each. Similarly, Groups II and III were sub-divided into IIA (male), IIB (female) and IIIA (male), IIIB (female), respectively, of six birds each. Observations were made up to the age of 5 weeks. Male experimental groups (IIA and IIIA) showed significantly increased testicular activity, cloacal gland volume, body weight (BW), plasma testosterone and LH level in comparison to control (IA). Similarly female experimental groups (IIB and IIIB) showed significantly greater weight of reproductive organs (uterus, ovary, oviduct and ovarian follicle), BW, egg weight and size and number of follicles. On the other hand, plasma prolactin level was significantly low in comparison to control (IB). Results suggest that M. pruriens is a rich natural source of L-DOPA and the development and reproduction in Japanese quail might be associated with the dopaminergic system of the brain.Keywords: reproduction, Mucuna pruriens, L-DOPA, nutrition, Japanese quail IntroductionAccording to our present knowledge, neuropeptides and biogenic amines are the most important secretions of neuroendocrine cells. The role of the central nervous system (CNS) neurotransmitters, which appear to be the mediator of many control mechanisms in mammals (Weiner and Ganong, 1978), is little understood in other vertebrate groups except for mammals. The neuroendocrine system is an integral component of the neuronal apparatus of the brain, a major portion of which is concentrated in the hypothalamus. The hypothalamic monoamines dopamine (3,4-dihydroxyphenylalanine), noradrenalin and serotonin have profound effects on the release of mammalian pituitary hormones, presumably in most cases by modulating the release of the hypothalamic hormone . The hypothalamus is of paramount importance as an 'integration center' for the various influences on pituitary function. The hypothalamus apparently responds to the exteroceptive and interoceptive stimuli by altering the secretion of certain neurotransmitters and release hormones. Ideally, a study of the control of pituitary function should not only show the effects of any particular influence on hormone secretion but also demonstrate the changes in the metabolism of neurotransmitters and release of inhibiting hormones. Dopamine (DA) is reported to be synthesized large...

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Specific neural phase relation of serotonin and dopamine modulate the testicular activity in Japanese quail

Banerjee

Chaturvedi

2018

Journal Cellular Physiology

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Specific phase relation of serotonin and dopamine modulate the hypothalamo-hypophyseal-gonadal axis as well as photosexual responses in Japanese quail, but the effect of these specific phase relations on testicular activity and steroidogenesis is not yet been investigated. We hypothesized that temporal phase relation induced alteration in local testicular gonadotropin-releasing hormone (GnRH)-Gonadotropin-inhibitory hormone (GnIH) and their receptor system may modulate the testicular activity and steroidogenesis through local (paracrine and autocrine) action. To validate this hypothesis, we have checked the alterations in the expression of gonadotropin-releasing hormone receptor (GnRH-R), gonadotropin-inhibitory hormone receptor (GnIH-R) messenger RNA (mRNA), growth hormone receptor (GH-R), proliferating cell nuclear antigen (PCNA), cell communication and gap junctional proteins (14-3-3 and connexin-43 [Cnx-43]), steroidogenic factor-1 (SF-1), steroidogenic acute regulatory (StAR) protein, steroidogenic enzyme (3β-hydroxysteroid dehydrogenase [3β-HSD]) in testis as well as androgen receptor (AR) in testis and epididymis of control, 8-, and 12-hr quail. Experimental findings clearly indicate the increased expression of GnIH-R mRNA and suppression of GnRH-R, GH-R, PCNA, 14-3-3, Cnx-43, SF-1, StAR, 3β-HSD in testis as well as AR in testis and epididymis in 8-hr quail, while 12-hr quail exhibited the opposite results that is significantly decreased expression of GnIH-R mRNA and increased expression of GnRH-R, GH-R, PCNA, 14-3-3, Cnx-43, SF-1, StAR, 3β-HSD in testis as well as AR in testis and epididymis. The significantly increased intratesticular testosterone has been observed in the 12-hr quail while, 8-hr quail showed opposite result. Hence, it can be concluded that 12-hr quail showed significantly increased testicular activity and steroidogenesis while opposite pattern was observed in 8-hr quail.

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The effect of different temporal relationships of 5‐hydroxytryptophan (5‐HTP) and l‐dihydroxyphenylalanine (L‐DOPA) on reproductive and metabolic responses of migratory red‐headed bunting (Emberiza bruniceps)

Cited by 30 publications

References 23 publications

Apoptosis-mediated testicular alteration in Japanese quail (Coturnix coturnix japonica) in response to temporal phase relation of serotonergic and dopaminergic oscillations

Apoptosis-mediated testicular alteration in Japanese quail (Coturnix coturnix japonica) in response to temporal phase relation of serotonergic and dopaminergic oscillations

Mucuna pruriens seed powder feeding influences reproductive conditions and development in Japanese quail Coturnix coturnix japonica

Specific neural phase relation of serotonin and dopamine modulate the testicular activity in Japanese quail

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