The effect of dioxidovanadium complex (V) on hepatic function in streptozotocin-induced diabetic rats

Abstract

Diabetics are susceptible to hepatic dysfunction risks due to hyperglycaemia and insulin therapy. Conventional diabetes treatments improve glycaemic control; however, hepatic hazards associated with these agents remains a challenge. Accordingly, this study sought to investigate the effect of a dioxidovanadium complex (V) on the hepatic function in streptozotocin-induced diabetic rats. Sprague-Dawley rats (240–250 g) were divided into 4 groups (n = 6): nondiabetic control, diabetic control, insulin-treated, and vanadium complex groups. The dioxidovanadium (10, 20, and 40 mg/kg) was administered twice every 2nd day for 5 weeks and blood glucose concentration was monitored weekly. At the end of the experimental period, all the experimental groups were sacrificed, and then the lipid profile, liver superoxide dismutase, glutathione peroxidase and malondialdehyde, plasma alanine aminotransferase and aspartate aminotransferase, and C-reactive protein (CRP) concentration were measured. The administration of dioxidovanadium significantly alleviated hyperglycaemia with concomitant attenuation in oxidative stress as evidenced by reduced malondialdehyde concentrations. Furthermore, vanadium complex abolished diabetes-induced dyslipidaemia. Lastly, vanadium complex administration attenuated the increase in alanine aminotransferase, aspartate aminotransferase, and plasma C-reactive protein. These findings suggest that this metallo-compound (dioxidovanadium) may ameliorate liver dysfunction often observed in diabetes.

Heamanetic Effects of a Dioxidovanadium(V) Complex in STZ-Induced Diabetic Male Sprague Dawley Rats

“…21 In this study, dioxidovanadium(V) complex, cis-[VO2 (obz)py] {Hobz=2-hydroxyphenyl-1H-benzimidazole and py =pyridine}] has been synthesized and conjoined with organic heterocyclic ligands, which eliminate toxicity and improve the complexs' potency. 13 . We have shown that the administration of this vanadium complex attenuates hyperglycaemia in streptozotocin-induced diabetic rats.…”

“… 13 These observations are very crucial moving forward, considering toxicity reported with other vanadium complexes. 13 , 15 In light of these findings, we sought to advance further, and investigate the effect of dioxidovanadium(V) complex on selected haematological markers in in STZ-induced diabetic male Sprague Dawley rats.…”

“…11 Similarly, other diabetic drugs such as metformin have been shown to inhibit the absorption of vitamin B12 in the gastro-intestinal tract resulting in anaemia. 13 These challenges presented by conventional treatments warrant the continuous search for novel compounds that may provide glycaemic control and alleviate hyperglycaemia-induced cardiovascular complications associated with haematological changes. 14 Vanadium compounds have been shown to act as effective hypoglycaemic agents however, their use has been associated with kidney, brain and liver toxicity.…”

“…14,15 In our laboratory we have synthesized a novel vanadium complex such as dioxidovanadium(V) complex, cis-[VO2 (obz)py] {Hobz=2-hydroxyphenyl-1H-benzimidazole and py =pyridine}] which is linked to organic heterocyclic ligands that provide thermodynamic stability and efficient vanadium transport to target tissues, rendering the complex safer, more potent and stable for use. [13][14][15] Previous studies in our laboratory have shown that the administration of this vanadium complex attenuates hyperglycaemia in streptozotocin-induced diabetic rats. 13 Moreover, the administration of this compound showed no hepatic hazards as evidenced by normal ALT and AST, suggesting non-toxicological effects.…”

“…[13][14][15] Previous studies in our laboratory have shown that the administration of this vanadium complex attenuates hyperglycaemia in streptozotocin-induced diabetic rats. 13 Moreover, the administration of this compound showed no hepatic hazards as evidenced by normal ALT and AST, suggesting non-toxicological effects. 13 These observations are very crucial moving forward, considering toxicity reported with other vanadium complexes.…”