The therapeutic effect
of common ocular drug delivery systems is
often limited because tear fluid, protective biological barriers,
and the blink reflex prevent drugs from reaching their target. Combining
nanodrug delivery systems with contact lenses is one approach to increase
the precorneal residence time and thus the drug concentration in the
eye. Hence, the aim of this study was to selectively print itraconazole
(ITZ) nanocrystals on commercially available 1 day soft hydrogel contact
lenses using inkjet printing. For this, ITZ nanocrystals stabilized
with Poloxamer 407 were prepared and optimized via wet media milling.
After careful characterization, the nanocrystals were printed into
vials, the printing process was adjusted, and the characteristics
of the nanoformulation after printing were investigated. Finally,
nanocrystals were printed onto hydrogel contact lenses. By performing
a concise design of experiments (DoE), stable nanocrystals with a
size of approximately 200 nm, a narrow particle size distribution,
a negative surface charge, and an almost spherical shape were obtained.
Compared to the bulk material, the apparent solubility was significantly
increased and no changes in the solid-state behavior occurred. It
was further demonstrated that inkjet printing did not affect the characteristics
of the nanocrystals. Multiple layers of the ITZ nanoformulation were
printed on soft hydrogel 1 day contact lenses, and a dual drug release
profile was obtained in simulated tear fluid. These results clearly
show that printing on contact lenses is a promising application for
ophthalmic drug delivery.