The effect of elastin on chondrocyte adhesion and proliferation on poly (ɛ-caprolactone)/elastin composites

Annabi, Nasim; Fathi, Ali; Mithieux, Suzanne M.; Martens, Penny J.; Weiss, Anthony S.; Dehghani, Fariba

doi:10.1016/j.biomaterials.2010.10.024

Cited by 120 publications

(80 citation statements)

References 37 publications

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“…Here, we investigated the effects of these variables on the physical properties (i.e., porosity and swellability) of the engineered GelMA hydrogels (Figure 2). The porosity of a hydrogel is key for its interaction with cells and the surrounding tissues 2, 38–40 . The modulation of the micro-architectural properties and the porosity of a hydrogel could be used to deliver bioactive cues to cells growing within the engineered constructs 2, 39 .…”

Section: Resultsmentioning

confidence: 99%

In vitro and in vivo analysis of visible light crosslinkable gelatin methacryloyl (GelMA) hydrogels

et al. 2017

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Photocrosslinkable materials have been frequently used for constructing soft and biomimetic hydrogels for tissue engineering. Although, ultraviolet (UV) light is commonly used for photocrosslinking such materials, its use has been associated with several biosafety concerns such as DNA damage, accelerated aging of tissues, and cancer. Here we report an injectable visible light crosslinked gelatin-based hydrogel for myocardium regeneration. Mechanical characterization revealed that the compressive moduli of the engineered hydrogels could be tuned in the range of 5–56 kPa, by changing the concentrations of the co-initiator and co-monomer in the precursor formulation. In addition, the average pore sizes (26–103 μm) and swelling ratio (7–13%) were also shown to be tunable by varying the hydrogel formulation. In vitro studies showed that visible light crosslinked GelMA hydrogels supported the growth and function of primary cardiomyocytes (CMs). In addition, the engineered materials were shown to be biocompatible in vivo, and could be successfully delivered to the heart after myocardial infarction in an animal model to promote tissue healing. The developed visible light crosslinked hydrogel could be used for the repair of various soft tissues such as the myocardium, and for the treatment of cardiovascular diseases with enhanced therapeutic functionality.

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Section: Resultsmentioning

confidence: 99%

In vitro and in vivo analysis of visible light crosslinkable gelatin methacryloyl (GelMA) hydrogels

et al. 2017

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“…[57] Notably, Annabi et al prepared a macroporous network based on polycaprolactone (PCL) and elastin by simultaneously using NaCl particles as a porogen and CO 2 as a gas foaming agent, leading to the creation of a uniformly distributed macroporous structure. [58] …”

Section: Gas Foamingmentioning

confidence: 99%

Structured Macroporous Hydrogels: Progress, Challenges, and Opportunities

Hoare

2017

Adv Healthcare Materials

178

168

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Structured macroporous hydrogels that have controllable porosities on both the nanoscale and the microscale offer both the swelling and interfacial properties of bulk hydrogels as well as the transport properties of “hard” macroporous materials. While a variety of techniques such as solvent casting, freeze drying, gas foaming, and phase separation have been developed to fabricate structured macroporous hydrogels, the typically weak mechanics and isotropic pore structures achieved as well as the required use of solvent/additives in the preparation process all limit the potential applications of these materials, particularly in biomedical contexts. This review highlights recent developments in the field of structured macroporous hydrogels aiming to increase network strength, create anisotropy and directionality within the networks, and utilize solvent‐free or additive‐free fabrication methods. Such functional materials are well suited for not only biomedical applications like tissue engineering and drug delivery but also selective filtration, environmental sorption, and the physical templating of secondary networks.

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“…The crosslinking degree has been shown to be correlated to colour intensity [48,49]; the measurement of colour intensity was processed using Image J software [50]. As shown in Fig.…”

Section: Crosslinking Characterizationmentioning

confidence: 99%

Fabrication of porous chitosan scaffolds for soft tissue engineering using dense gas CO2

et al. 2011

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The effect of elastin on chondrocyte adhesion and proliferation on poly (ɛ-caprolactone)/elastin composites

Cited by 120 publications

References 37 publications

In vitro and in vivo analysis of visible light crosslinkable gelatin methacryloyl (GelMA) hydrogels

In vitro and in vivo analysis of visible light crosslinkable gelatin methacryloyl (GelMA) hydrogels

Structured Macroporous Hydrogels: Progress, Challenges, and Opportunities

Fabrication of porous chitosan scaffolds for soft tissue engineering using dense gas CO2

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