The Effect of Ethanol Extract of Ripe Denettia tripetala Fruit (Pepper Fruit) on Indices of Liver and Kidney Function in Male Albino Wistar Rats

Akpakpan, Ekam Ime; Bassey, Utibe Evans; Etim, Okon Effiom; Ekanemesang, U

doi:10.9734/ijbcrr/2017/31490

Cited by 3 publications

(6 citation statements)

References 13 publications

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“…The fruit samples were authenticated by a Botanist in Department of Botany and Ecological Studies, University of Uyo, Akwa Ibom State. The fruits were processed as described by Akpakpan et al [2] . They were washed, air dried at room temperature and grounded into powder with mortar and pestle.…”

Section: Denettia Tripetalamentioning

confidence: 99%

“…Recent studies by Akpakpan et al has reported that D. tripetala at doses ranging between 262.20mg/kg and 786.61mg/kg is not toxic to the liver and kidney of normal albino Wistar rats [2] . The present study evaluated the effect of ethanol extract of crude extract of Dennetia tripetala on the function of prostate and testes of healthy albino wistar rats.…”

Section: Introductionmentioning

confidence: 98%

“…The leaves are commonly used in pepper soup delicacies and as condiments in some special local dishes [1] . fruit [2] .…”

Section: Introductionmentioning

confidence: 99%

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Effect of ethanol extract of ripe fruits of Dennetia tripetala on prostatic and testicular functions of male albino rats

Bassey¹,

Akpakpan²,

Etim³

et al. 2018

J. Med. Res.

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The effects of ethanol extract of ripe fruits of Dennetia tripetala on prostatic and testicular functions of male albino Wistar rats were investigated. Twenty male albino rats weighing between 160 -180g were divided into 4 groups with 5 animals in each group. Group 1 served as the control while Groups 2, 3 and 4 were orally administered 300 mg/kg, 600 mg/kg and 900 mg/kg of ethanol extract of ripe Dennetia tripetala fruits respectively daily for 28 days. Blood samples were collected through cardiac puncture, serum obtained for assay of prostate specific antigen (PSA) and testosterone levels while prostates and testes were excised and used for histological evaluation. The results showed a non-significant (P > 0.05) dose dependent decrease in the concentration of PSA. A non-significant decrease in testosterone levels in Groups 2 and 3 when compared to control was also recorded in this study while a significant decrease was observed in Group 4. Normal histological features were observed in the histology of the prostate while the presence of mature sperm cells in the photomicrograph of the testes of the treated groups suggest increased spermatogenesis following the administration of the extract. The results therefore suggest a beneficial effect of Dennetia tripetala in reducing PSA levels with possible improvement in spermatogenesis. It also showed no toxic effect on prostate and testes of the experimental animal.

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Section: Denettia Tripetalamentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

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Effect of ethanol extract of ripe fruits of Dennetia tripetala on prostatic and testicular functions of male albino rats

Bassey¹,

Akpakpan²,

Etim³

et al. 2018

J. Med. Res.

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“…The experimental animal were grouped into six groups composing of 4 animals in each as vix: Group I as the negative control, Group II as the positive control received normal saline, Group III for the experimental animal were treated with vitmain B6 (pyridoxin). Group IV to VI were composed of experimental animal treated with different dosing of ethanolic fuits extract of Dennettia tripetala as adopted from Akpakpan et al [9] and modified. Thirty minutes after administration of water to group II, test drug (extract) to groups IV to VI and 30 minutes after pyridoxine administration to group III; Group II to VI were treated with 300 mg/kg-bw INH by intraperitonial route.…”

Section: Experimental Design and Animal Groupingmentioning

confidence: 99%

Antioxidant and Anticonvulsant Effect of Dennettia Tripetala on Rat Model of Isoniazid-induced Seizure

Finbarrs-Bello

Ozor

Ojuolape

et al. 2019

EJMP

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Aims:This study aimed at investigating the antioxidative, anticonvulsive and histological effects of ethanolic fruit extract of Dennettia tripetala on the pre-frontal lobe of the brain in isoniazid-induced (300 mg/kg, i.p) seizure in adult wistar rat. Introduction: Neuronal hyper-excitability and excessive production of free radicals have been implicated in the pathogenesis of a considerable range of neurological disorders, including epilepsy. The high rate of oxidative metabolism, coupled with the low antioxidant defenses and the richness in polyunsaturated fatty acids, makes the brain highly vulnerable to free radical damage. Study Design: This is an original research conducted in Finbarrs-Bello et al.; EJMP, 30(2): 1-10, 2019; Article no.EJMP.52261 2 Methodology: A total number of twenty four wistar rats were used for this experiment, the animals were grouped into six groups with four animals per group, Group I served as the negative control, Group II served as the positive control, Group III received the standard drug as well as the Isoniazid, while group IV, V and VI were treated with ethanolic extract of Dennettia tripetala at different dosages; 250 mg/kg, 500 mg/kg and 750 mg/kg, intraperitoneally (i.p) respectively and its effects compared with a standard drug (Pyridoxine) treated group. Results: The extract significantly prolonged the onset of seizure at high dose administration (750 mg/kg) but completely prevented seizure occurrence at low and medium dose administration (250 mg/kg and 500 mg/kg, i.p) when induced with isoniazid (300 mg/kg, i.p.). Conclusion: The results obtained from this work suggest that ethanolic extract of Dennettia tripetala has anticonvulsant activity, and this supports the use of the formulation traditionally in the treatment of convulsions, thus should be considered for clinical trials. Original Research Article

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“…It is traditionally used for the treatment of cough, toothache, fever, diabetes and nausea during pregnancy. Its antioxidant, antihyperglycemic, anti-inflammatory and antinociceptive effects have been established in vivo [10,11,12]. The aim of this study was to evaluate the antioxidant potentials of ethanol extract of unripe and ripe DT fruits.…”

Section: Introductionmentioning

confidence: 99%

In vitro Antioxidant Potentials of Ethanol Extract of Unripe and Ripe Dennetia tripetala Fruits

Akpakpan

Onyeike

Ogunka-Nnoka

2019

JOCAMR

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Dennettia tripetala fruit is a popular Nigerian fruit from the family of plant known as Annonaceae. The whole fruit (flesh and seed) is usually consumed as snacks and it is oftentimes consumed with local gin (ufofop in Ibibio or kaikai in Igbo) or added to dishes as spice due to its peculiar strong pepperish taste and sweet aroma. The present study is aimed at evaluating the antioxidant potentials of ethanol extract of ripe and unripe D. tripetala (DT) fruit in vitro. The antioxidant activity of the ethanol extract of DT was evaluated spectrophotometrically using various in vitro models like 1, 1-diphenyl-2-picryl-hydrazyl (DPPH) and hydrogen peroxide scavenging activity; metal chelating activity and reducing power. Vitamin C was used as the standard antioxidant.Unripe and ripe DT fruits, as well as vitamin C showed a competitive inhibition of DPPH and H2O2 free radicals. As concentration of the extracts increased from 20 to100 µg/mL, the % scavenging activity for vitamin C increased from 87.86 ± 0.11 to 90.66 ± 0.07 and for ripe DT fruits from 15.15 ± 0.24 to 25.52 ± 0.23, while for unripe, fruits values increased from 12.09 ± 0.35 to 23.06 ± 0.12. The IC50 values was highest in unripe (549.23) followed by ripe (276.63) and lowest in vitamin C (12.92) indicating that vitamin C was the best scavenger of DPPH radical. Similar trend was obtained for H2O2 scavenging activity as well as reducing power. Unripe DT fruit extract was more potent at chelating metal ions (IC50 was 95.38), followed by the standard ascorbic acid with IC50 of 97.03 and was lowest in ripe DT fruit extract with IC50 value of 124.66. Unripe and ripe DT are potent antioxidants in nature and may be used to supplement our diets as rich sources of natural antioxidants for health protection.

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The Effect of Ethanol Extract of Ripe Denettia tripetala Fruit (Pepper Fruit) on Indices of Liver and Kidney Function in Male Albino Wistar Rats

Cited by 3 publications

References 13 publications

Effect of ethanol extract of ripe fruits of Dennetia tripetala on prostatic and testicular functions of male albino rats

Effect of ethanol extract of ripe fruits of Dennetia tripetala on prostatic and testicular functions of male albino rats

Antioxidant and Anticonvulsant Effect of Dennettia Tripetala on Rat Model of Isoniazid-induced Seizure

In vitro Antioxidant Potentials of Ethanol Extract of Unripe and Ripe Dennetia tripetala Fruits

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