The effect of exercise on GABA signaling pathway in the model of chemically induced seizures

pour, Mitra Barzroodi; Bayat, Mohammad; Golab, Freshteh; Eftekharzadeh, Mina; Katebi, Majid; Soleimani, Mansoureh; Karimzadeh, Fariba

doi:10.1016/j.lfs.2019.116667

Cited by 19 publications

(14 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In addition, while normal hippocampal function requires a balance between excitation and inhibition, abnormal hippocampal excitation in pathological aging has also been linked to GABAergic inhibitory dysfunction (Hazra et al, 2013;Tong et al, 2014). Aerobic exercise, in turn, has been demonstrated to induce neuroprotective inhibitory modulation in the hippocampus of hyper-excitatory epileptic rats (Lim et al, 2015;Barzroodi Pour et al, 2019). This, in turn, suggests another potential neurobiological mechanism that may underlie the relationship between aerobic exercise and attenuated hippocampal hyperactivity observed in this study.…”

Section: Discussionmentioning

confidence: 53%

Physically Active Lifestyle Is Associated With Attenuation of Hippocampal Dysfunction in Cognitively Intact Older Adults

Eisenstein

Giladi

Hendler

et al. 2021

Front. Aging Neurosci.

View full text Add to dashboard Cite

Alterations in hippocampal function have been shown in older adults, which are expressed as changes in hippocampal activity and connectivity. While hippocampal activation during memory demands has been demonstrated to decrease with age, some older individuals present increased activity, or hyperactivity, of the hippocampus which is associated with increased neuropathology and poor memory function. In addition, lower functional coherence between the hippocampus and core hubs of the default mode network (DMN), namely, the posteromedial and medial prefrontal cortices, as well as increased local intrahippocampal connectivity, were also demonstrated in cognitively intact older adults. Aerobic exercise has been shown to elicit neuroprotective effects on hippocampal structure and vasculature in aging, and improvements in cardiorespiratory fitness have been suggested to mediate these exercise-related effects. However, how these lifestyle factors relate to hippocampal function is not clear. Fifty-two cognitively intact older adults (aged 65–80 years) have been recruited and divided into physically active (n = 29) or non-active (n = 23) groups based on their aerobic activity lifestyle habits. Participants underwent resting-state and task-based fMRI experiments which included an associative memory encoding paradigm followed by a post-scan memory recognition test. In addition, 44 participants also performed cardiopulmonary exercise tests to evaluate cardiorespiratory fitness by measuring peak oxygen consumption (Vo2peak). While both groups demonstrated increased anterior hippocampal activation during memory encoding, a physically active lifestyle was associated with significantly lower activity level and higher memory performance in the recognition task. In addition, the physically active group also demonstrated higher functional connectivity of the anterior and posterior hippocampi with the core hubs of the DMN and lower local intra-hippocampal connectivity within and between hemispheres. Vo2peak was negatively associated with the hippocampal activation level and demonstrated a positive correlation with hippocampal-DMN connectivity. According to these findings, an aerobically active lifestyle may be associated with attenuation of hippocampal dysfunction in cognitively intact older adults.

show abstract

Section: Discussionmentioning

confidence: 53%

Physically Active Lifestyle Is Associated With Attenuation of Hippocampal Dysfunction in Cognitively Intact Older Adults

Eisenstein

Giladi

Hendler

et al. 2021

Front. Aging Neurosci.

View full text Add to dashboard Cite

show abstract

“…In rat models of temporal lobe epilepsy and absence epilepsy, the exercise group experienced a significant reduction in seizure frequency compared to controls and sham groups [49,50]. Studies conducted using a rat pentylenetetrazole model determined that exercise decreased seizure susceptibility, frequency, and latency [51,52].…”

Section: 4mentioning

confidence: 99%

Drivers for the comorbidity of type 2 diabetes mellitus and epilepsy: A scoping review

Shlobin

Sander

2020

Epilepsy & Behavior

View full text Add to dashboard Cite

Epilepsy, a common neurologic condition, is associated with a greater prevalence of type 2 diabetes mellitus (T2DM). We examined potential drivers for the comorbidity of epilepsy and T2DM in an attempt to elucidate possible biological mechanisms underlying the development of processes in individuals. We searched PubMed and Medline up to December 2019. Our search yielded 3,361 articles, of which 82 were included in the scoping review. We reviewed articles with a focus on the association of epilepsy and T2DM, drivers, and biological mechanisms. Epilepsy is associated with obesity and obesity is associated with T2DM. Treatment with valproate (either sodium or acid) is associated with weight increase and hyperinsulinemia, while topiramate causes weight loss. People with epilepsy are less likely to exercise which is protective against obesity. Mitochondrial dysfunction and adiponectin deficiency are common to epilepsy and T2DM. One possible mechanism for the comorbidity is mitochondrial dysfunction and adiponectin deficiency which promotes epilepsy, obesity, and T2DM. Another possible mechanism is that people with epilepsy are more likely to be obese due to lack of exercise and the effects of some antiseizure medications, which makes them susceptible to T2DM due to the development of mitochondrial dysfunction and adiponectin deficiency. A third mechanism is that people with epilepsy have greater mitochondrial dysfunction and lower adiponectin levels than people without epilepsy at baseline, which may exacerbate after treatment with antiseizure medications. Future research involving a combined genetic and molecular pathway approach will likely yield valuable insight regarding the comorbidity of epilepsy and T2DM.

show abstract

“…In addition, while normal hippocampal function requires a balance between excitation and inhibition, abnormal hippocampal excitation in pathological aging has been also linked to GABAergic inhibitory dysfunction 73,74 . Aerobic exercise in turn, has been demonstrated to induce neuroprotective inhibitory modulation in the hippocampus of hyper-excitatory epileptic rats 75,76 . This in turn, suggests another potential neurobiological mechanism which may underlie the relationship between aerobic exercise and attenuated hippocampal hyperactivity observed in the current study.…”

Section: Discussionmentioning

confidence: 99%

Physically active lifestyle is associated with attenuation of hippocampal dysfunction in healthy older adults

Eisenstein

Giladi

Hendler

et al. 2021

Preprint

View full text Add to dashboard Cite

Alterations in hippocampal function have been shown in older adults, expressed as changes in hippocampal activity and connectivity. While hippocampal activation during memory demands have been demonstrated to decrease with age, some older individuals present increased activity, or hyperactivity, of the hippocampus which is associated with increased neuropathology and poorer memory function. In addition, lower functional coherence between the hippocampus and core hubs of the default mode network (DMN), namely the posteromedial and medial prefrontal cortices, as well as increased local intrahippocampal connectivity, were also demonstrated in cognitively intact older adults. Aerobic exercise has been shown to elicit neuroprotective effects on hippocampal structure and vasculature in aging, and improvements in maximal aerobic capacity (MAC) have been suggested to mediate these exercise-related effects. However, how these lifestyle factors relate to hippocampal function is not clear. Fifty-two cognitively intact older adults (age 65-80) have been recruited and divided into physically active (n=29) or non-active (n=23) groups based on their aerobic activity lifestyle habits. Participants underwent resting-state as well as task-based fMRI experiments which included an associative memory encoding paradigm followed by a post-scan memory recognition test. In addition, forty-four participants also performed cardiopulmonary exercise tests to evaluate MAC. While both groups demonstrated increased anterior hippocampal activation during memory encoding, physically active lifestyle was associated with significantly lower activity level and higher memory performance in the recognition task. In addition, the physically active group also demonstrated higher functional connectivity of the anterior and posterior hippocampi with the core hubs of the DMN, and lower local intra-hippocampal connectivity within and between hemispheres. MAC was negatively associated with hippocampal activation level and demonstrated positive correlation with hippocampal-DMN connectivity. According to these findings, aerobically active lifestyle may be associated with attenuation of hippocampal dysfunction in cognitively healthy older adults.

show abstract

The effect of exercise on GABA signaling pathway in the model of chemically induced seizures

Cited by 19 publications

References 55 publications

Physically Active Lifestyle Is Associated With Attenuation of Hippocampal Dysfunction in Cognitively Intact Older Adults

Physically Active Lifestyle Is Associated With Attenuation of Hippocampal Dysfunction in Cognitively Intact Older Adults

Drivers for the comorbidity of type 2 diabetes mellitus and epilepsy: A scoping review

Physically active lifestyle is associated with attenuation of hippocampal dysfunction in healthy older adults

Contact Info

Product

Resources

About