The Effect of Exogenous Melatonin on Experimental Colonic Anastomosis

Özdoğan, Mete; Oruk, I; Renda, Nurten; Kaynaroğlu, Volkan; Baykal, Atac

doi:10.1080/00015458.2005.11679721

Cited by 3 publications

(4 citation statements)

References 14 publications

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“…[4] As OHP is the main determinant of collagen content within tissue, a correlation exists. [30] In the present study, higher levels of OHP were observed in the treatment group at all times, and significantly higher collagen deposits were also observed. BPs measured on the 7 th postoperative day were significantly higher in treated rats.…”

Section: Groupssupporting

confidence: 61%

“…[31] Similarly, Ozdogan et al found no beneficial effect of exogenous melatonin on colonic anastomosis. [30] On the other hand, Ozen et al reported that melatonin had a dose-independent positive effect on wound healing of colonic anastomosis in the presence of peritonitis. The authors found significantly higher burst pressure and glutathione levels in rats treated with a high dose of melatonin.…”

Section: Groupsmentioning

confidence: 99%

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Effects of Melatonin on Cytokin Release and Healing of Colonic Anastomoses in an Experimental Sepsis Model

Ersoy

Özkan

Özsoy

et al. 2015

Ulus Travma Acil Cerrahi Derg

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BACKGROUND:The present objective was to identify effects of early melatonin application on healing of anastomotic wound and inflammation in an experimental sepsis model. METHODS: A total of 60 Wistar albino rats were divided into 2 groups. Cecal ligation puncture (CLP) and colonic resection anastomosis were performed on both the control group and the melatonin treatment group. Both groups were divided into 3 subgroups consisting of 10 rats each. One subgroup from each group underwent re-laparotomy at the 16 th hour, the next on the 3 rd day, and the final subgroup on the 7 th day. Presently evaluated were effects of melatonin treatment of early sepsis on interleukin-6 (IL-6), interleukin-10 (IL-10), interferon gamma (INF-γ), and C-reactive protein (CRP) levels, as well as burst pressures (BPs), collagen and hydroxyproline (OHP) content of the anastomotic segments, histopathologic healing, immunohistochemical expressions, CD34, and transforming growth factor beta (TGF-β). RESULTS: IL-6 and INF-γ levels of the treatment group showed a significant decrease at the 16 th hour and an increase on the 3 rd and 7 th postoperative days. IL-10 levels were significantly higher at the 16 th hour and significantly lower on the 3 rd and 7 th postoperative days in the control group (p<0.001 for each). The treatment group also showed significantly higher capillary permeability, fibroblast proliferation, and collagen deposits (p<0.001 for each). CD34 expression was significantly increased in the treatment group on the 7

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Section: Groupssupporting

confidence: 61%

Section: Groupsmentioning

confidence: 99%

Effects of Melatonin on Cytokin Release and Healing of Colonic Anastomoses in an Experimental Sepsis Model

Ersoy

Özkan

Özsoy

et al. 2015

Ulus Travma Acil Cerrahi Derg

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“…However, there are contradictory reports on melatonin in the literature. Some researchers believe that melatonin exerts a protective effect on wound healing, whereas others are completely opposed to the idea [8,10,25,26] . In light of our results, we share the same belief as other authors who support melatonin's positive effect on wound healing.…”

Section: Discussionmentioning

confidence: 99%

“…Recently, the question of appropriate dose and the formulation of melatonin, and the adjustment of circadian rhythms has not been resolved [9,10,26] . Previous studies showed that the dosage and the duration of exogenous melatonin administration is variable and depends on the purpose of usage.…”

Section: Discussionmentioning

confidence: 99%

Effect of Melatonin on Healing of Colonic Anastomosis in a Rat Model of Peritonitis

Özen¹,

Ekíngen²,

Taşlıpınar

et al. 2006

Eur Surg Res

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Background: The aim of this study is to determine the effect of melatonin on intestinal anastomosis in the presence of peritonitis. Material and Methods: 32 Wistar albino rats were randomized into four groups (n = 8): A (sham), B (control), C (melatonin 5 mg/kg), and D (melatonin 10 mg/kg). In group A, only cecal dissection was carried out. In the other groups, cecal ligation and puncture (CLP) followed cecal dissection in order to induce bacterial peritonitis. 24 h after the previous operation, cecal resection and iliocolic anastomosis were performed in the rats of all groups. In group C (5 mg/kg) and group D (10 mg/kg), melatonin was injected for 5 consecutive days starting after CLP. At the 48th hour of the CLP procedure, blood was drawn via the tail vein for tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) analysis, and on the 4th day of the experiment relaparotomy was carried out for bursting pressure (BP) measurements. The intestinal tissue containing the anastomotic line was then snap-frozen in liquid nitrogen and stored at –80°C for determination of tissue levels of malondialdehyde (MDA) and glutathione (GSH). Results: The tissue MDA level, blood TNF-α and IL-6 levels of group B were significantly higher than in the other groups, whereas the BP results and GSH levels of group B were found to be significantly lower than in the other groups. The results of groups C and D are statistically different from those of group B. When we compared the results of groups C and D, we found significantly higher results in terms of BP and GSH levels in group D and also significantly lower results in terms of MDA, blood TNF-α and IL-6 levels in group D. Conclusion: The findings of this experiment suggest that melatonin has a dose-independent positive effect on wound healing of colonic anastomosis.

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Pharmacological interventions for improved colonic anastomotic healing: A meta-analysis

Øines

Krarup

Jørgensen

et al. 2014

WJG

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The Effect of Exogenous Melatonin on Experimental Colonic Anastomosis

Abstract: Results suggest that exogenous melatonin has no beneficial effect on the healing of colonic anastomosis.

Cited by 3 publications

References 14 publications

Effects of Melatonin on Cytokin Release and Healing of Colonic Anastomoses in an Experimental Sepsis Model

Effects of Melatonin on Cytokin Release and Healing of Colonic Anastomoses in an Experimental Sepsis Model

Effect of Melatonin on Healing of Colonic Anastomosis in a Rat Model of Peritonitis

Pharmacological interventions for improved colonic anastomotic healing: A meta-analysis

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