The Effect of Fermented Codonopsis lanceolata on the Memory Impairment of Mice

박성진,; 박동식,; 김승섭,; 허신용,; 안주희,; 윤원병,; 이현용,

doi:10.3746/jkfn.2010.39.11.1691

Cited by 7 publications

(3 citation statements)

References 11 publications

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“…, al., 1982;Chun et al, 1997;Mun et al, 2004;Kim et al, 2005;Park et al, 2005;Chung et al, 2008;Shin et al, 2009). , , (Park et al, 2010). , 2 .…”

Section: 서 론mentioning

confidence: 99%

Effects of Dietary Supplementation of Fermented Garlic Powder and Fluid on Growth Performance, Immune Responses, Blood Components, and Disease Resistance against Edwardsiella tarda and Streptococcus iniae in Olive Flounder Paralichthys olivaceus

Kim¹,

Kim²,

Jeong³

et al. 2011

Korean Journal of Fisheries and Aquatic Sciences

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Two consecutive studies were conducted to evaluate the effects of dietary supplementation with fermented garlic powder (FGP) or fermented garlic fluid (FGF) on growth performance, immune responses, and disease resistance of olive flounder Paralichthys olivaceus. In experiment I, olive flounder (BW: 65 g) were fed four experimental diets formulated to contain 0%, 0.5%, 1%, and 1.5% FGP (designated as FGP-0, FGP-0.5, FGP-1, and FGP-1.5, respectively). After the 10-weeks feeding trial, feed intake was significantly lower in fish fed the FGP-0.5 and FGP-1.0 diets, as compared to those fed the control diet. Fish fed the FGP-0 and FGP-0.5 diets showed significantly lower survival, as compared to the other treatments. Dietary supplementation with FGP resulted in higher non-specific immune responses than the FGP-0 group. Plasma cholesterol and triglyceride levels decreased as dietary FGP level increased. In experiment II, olive flounder (BW: 65 g) were fed four experimental diets for 10 weeks. The diets were prepared with a commercial expanded pellet to have 0%, 0.25%, 0.5%, and 1% FGF (designated as FGF-0, FGF-0.25, FGF-0.5, and FGF-1, respectively) by adsorption. At the end of the second feeding trial, feed intake was significantly lower in fish fed the FGF-0 diet, as compared to other treatments. Fish fed the FGF-0.25 and FGF-0.5 diets exhibited significantly lower cholesterol levels, as compared to other treatments. Lysozyme activity significantly increased with increases in dietary FGF. Cumulative mortality in a challenge test with Streptococcus iniae was significantly lower in the fish groups fed FGF-supplemented diets than in fish fed the control diet. The results of this study indicated that dietary supplementation with FGP or FGF can enhance the non-specific immune responses and disease resistance of olive flounder against S. iniae.

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“…, al., 1982;Chun et al, 1997;Mun et al, 2004;Kim et al, 2005;Park et al, 2005;Chung et al, 2008;Shin et al, 2009). , , (Park et al, 2010). , 2 .…”

Section: 서 론mentioning

confidence: 99%

Effects of Dietary Supplementation of Fermented Garlic Powder and Fluid on Growth Performance, Immune Responses, Blood Components, and Disease Resistance against Edwardsiella tarda and Streptococcus iniae in Olive Flounder Paralichthys olivaceus

Kim¹,

Kim²,

Jeong³

et al. 2011

Korean Journal of Fisheries and Aquatic Sciences

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“…For example, novel determinants of response to chemotherapy in colon cancer were identified by using pharmacogenomic approach [ 6 , 7 ]. The roots of Codonopsis lanceolata (CL) have been used as a traditional medicinal herb to treat several inflammatory diseases, memory impairment and inhibitory action of obesity in far east regions [ 8 , 9 ]. Some of them were obtained as they were (fresh or dry type) or simply extracted by hot water.…”

Section: Introductionmentioning

confidence: 99%

Microarray-Based Gene Expression Profiling to Elucidate Effectiveness of Fermented Codonopsis lanceolata in Mice

Choi

Kim

Park

et al. 2014

IJMS

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In this study, the effect of Codonopsis lanceolata fermented by lactic acid on controlling gene expression levels related to obesity was observed in an oligonucleotide chip microarray. Among 8170 genes, 393 genes were up regulated and 760 genes were down regulated in feeding the fermented C. lanceolata (FCL). Another 374 genes were up regulated and 527 genes down regulated without feeding the sample. The genes were not affected by the FCL sample. It was interesting that among those genes, Chytochrome P450, Dmbt1, LOC76487, and thyroid hormones, etc., were mostly up or down regulated. These genes are more related to lipid synthesis. We could conclude that the FCL possibly controlled the gene expression levels related to lipid synthesis, which resulted in reducing obesity. However, more detailed protein expression experiments should be carried out.

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“…. 본 연구팀은 증숙가공공정을 통한 더덕의 항산화 활성 증 진 (16), 증숙 및 발효 더덕의 이화학적 특성 및 생리활성 변 화 (17), 발효더덕의 화학성분 (18), 발효더덕 추출물이 흰쥐 의 인지능 회복에 미치는 효과 (19), 발효더덕 추출물의 생리 활성 (20), 초고압 추출 처리에 의한 더덕 및 발효더덕의 항산 화 증진 (5) Total phenolic content was expressed as mg/g gallic acid equivalent (GAE).…”

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Antioxidant Activities of Processed Deoduck (Codonopsis lanceolata) Extracts

Jeon¹,

Kim²,

Kim³

et al. 2013

Journal of the Korean Society of Food Science and Nutrition

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This study investigated the antioxidant activities of processed Deoduck (Codonopsis lanceolata) extracts treated through high-pressure extraction and steaming with fermentation. The antioxidant activities were determined for DPPH and ABTS radical-scavenging activity, SOD-like activity, ferric reducing antioxidant power (FRAP), and Fe 2+ chelating. Total phenolic and flavonoid contents were also measured. Among eight Deoduck extracts, the S5FDW extract had the highest total phenolic and flavonoid content, 73.9 mg GAE/g and 50.9 mg QUE/g, respectively. The S5FDW extract had the highest DPPH radical-scavenging activity (27%) at a 1.0 mg/mL concentration. The ABTS radical-scavenging activity was highest for S5FDW extract (82.1%) at a 10 mg/mL concentration. The HFDE extract showed the highest SOD-like activity (29.7%) at a 1.0 mg/mL concentration. FRAP was highest in S5FDW extract (140.8 μM) at a 1.0 mg/mL concentration. The DE extract showed the highest Fe 2+ chelating (46%) at a 1.0 mg/mL concentration. The phenolic and flavonoid contents significantly correlated with the antioxidant activity of several processed Deoduck extracts and was higher in the processed Deoduck extracts compared to the raw Deoduck extracts. Therefore, processing techniques can be useful methods for making Deoduck a more potent and natural antioxidant.

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The Effect of Fermented Codonopsis lanceolata on the Memory Impairment of Mice

Cited by 7 publications

References 11 publications

Effects of Dietary Supplementation of Fermented Garlic Powder and Fluid on Growth Performance, Immune Responses, Blood Components, and Disease Resistance against Edwardsiella tarda and Streptococcus iniae in Olive Flounder Paralichthys olivaceus

Effects of Dietary Supplementation of Fermented Garlic Powder and Fluid on Growth Performance, Immune Responses, Blood Components, and Disease Resistance against Edwardsiella tarda and Streptococcus iniae in Olive Flounder Paralichthys olivaceus

Microarray-Based Gene Expression Profiling to Elucidate Effectiveness of Fermented Codonopsis lanceolata in Mice

Antioxidant Activities of Processed Deoduck (Codonopsis lanceolata) Extracts

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