The effect of finasteride on spermatogenesis of Mesocricetus auratus

Vidigal, Dimas José Araújo; Silva, Alcino Lázaro da; Fonseca, Luiz Mauro Andrade da; Vasconcelos, A.C.; Resende, Dilermando Fazito de; Vidigal, Felipe Eduardo Costa

doi:10.1590/s0102-86502008000300012

Cited by 7 publications

(7 citation statements)

References 9 publications

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“…Even though Vidigal et al 24 observed changes in testicular parenchyma of finasteride treated hamsters, our results could not prove such assertive in short-term treated dogs. However, we believe that 2 month course of finasteride therapy was not a sufficient period to promote significant testicular and seminal changes, similarly to the results of Iguer-Ouada; Verstegen 25 .…”

Section: Discussioncontrasting

confidence: 94%

“…On the other hand, finasteride therapy in men has been demonstrated to cause erectile dysfunction, loss of libido and poor sperm quality, such as oligospermia and azoospermia 21 – 23 . In addition, Vidigal et al 24 showed reduction in spermatogenesis rate and seminiferous tubules atrophy in hamsters, indicating a possible irreversible and negative effect of finasteride therapy. In dogs, decreased sperm quality was only observed after long term treatment with finasteride 4 .…”

Section: Introductionmentioning

confidence: 99%

“…azoospermia [21][22][23] . In addition, Vidigal et al 24 showed reduction in spermatogenesis rate and seminiferous tubules atrophy in hamsters, indicating a possible irreversible and negative effect of finasteride therapy. In dogs, decreased sperm quality was only observed after long term treatment with finasteride 4 .…”

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confidence: 99%

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Reproductive and endocrinological effects of Benign Prostatic Hyperplasia and finasteride therapy in dogs

Angrimani

Brito

Rui

et al. 2020

Sci Rep

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Benign prostatic hyperplasia (BPH) is one of the most important reproductive disorders in aging dogs. Therapeutic measures include orchiectomy and pharmacological treatment, leading to reduction of prostate volume and clinical signs. One of the most common drugs used in BPH treatment is finasteride, but data regarding its possible side effects are scarce. Thus, the aim of this study was to evaluate the effects of BPH and short-term (2 months) finasteride therapy on clinical, endocrinological, and reproductive parameters in dogs. Dogs were allocated into four experimental groups: Non-affected (n = 5), BPH (n = 5), Non-Affected-Finasteride (n = 5) and BPH-Finasteride (n = 5) groups. Dogs were evaluated monthly during 2 months by a complete breeding soundness examination, B-mode ultrasound and Doppler ultrasonography of the testicular artery, hormonal profile (testosterone, estrogen and dihydrotestosterone) and oxidative profile of the prostatic fluid. After 2 months, dogs were gonadectomized and testicles were subjected to histologic analysis. Finasteride treatment reduced dihydrotestosterone concentrations, without negative influence on semen quality and also reverted testicular hemodynamics changes of BPH. On the other hand, BPH was accompanied by significant changes in testosterone and estrogen concentrations and semen quality, mainly related to sperm kinetics alterations. In conclusion, BPH dogs have important hormonal and sperm alterations, however, short-term finasteride treatment (2 months) was able to reduce overall effects of BPH, thus representing a method of therapy for BPH treatment.

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Section: Discussioncontrasting

confidence: 94%

Section: Introductionmentioning

confidence: 99%

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Reproductive and endocrinological effects of Benign Prostatic Hyperplasia and finasteride therapy in dogs

Angrimani

Brito

Rui

et al. 2020

Sci Rep

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“…Although Iguer-Ouada & Verstegen [18] have attested the fertility of dogs under 20 weeks of finasteride treatment, in men, finasteride causes oligospermia or azoospermia and sperm DNA fragmentation [19,20], related to a deleterious effect on spermatogenesis [19][20][21]. In addition, Vidigal et al [22] showed reduced spermatogenesis and seminiferous tubules atrophy in finasteride treated hamsters.…”

Section: Introductionmentioning

confidence: 99%

Does finasteride treatment for benign prostatic hyperplasia influence sperm DNA integrity in dogs?

Angrimani

Bicudo

Luceño

et al. 2020

Basic Clin. Androl.

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Background: Benign prostatic hyperplasia (BPH) is one of the most common reproductive disorders in both male dogs and men. Finasteride, a synthetic inhibitor of the enzyme 5α-reductase, is widely used as medical treatment. Although sperm can be affected by both BPH and finasteride treatment, the direct influence on DNA integrity remains unclear. Thus, the aim of this study was to verify the direct effect of BPH and/or finasteride treatment on DNA integrity of dog spermatozoa. A 2 × 2 factorial experiment was designed with 20 male dogs assigned to 4 experimental groups: BPH Group (n = 5), BPH-Finasteride Group (n = 5), Non-BPH Finasteride-Treated Group (n = 5) and Non-BPH Untreated Group (n = 5). Sperm evaluation was performed monthly for 60 days after the start of finasteride therapy or BPH diagnosis (D0, D30 and D60). Sperm DNA integrity was analyzed through fragmentation susceptibility (toluidine blue staining and Sperm Chromatic Structure Assay-SCSA), direct evaluation of DNA fragmentation (Sperm Chromatin Dispersion Assay-SCDA) and sperm protamination (chromomycin A3). Results: Sperm DNA integrity was not affected by finasteride treatment. However, BPH dogs had higher susceptibility to sperm DNA acid denaturation (SCSA) compared to dogs not presenting BPH, as well as lower percentage of sperm with DNA integrity (toluidine blue staining). Conclusion: In conclusion, benign prostatic hyperplasia causes post-testicular sperm DNA damage, albeit finasteride treatment itself does not directly influence sperm DNA integrity.

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“…Finasteride reduces the plasmatic levels of PSA, what could impair the detection of an eventual prostate neoplasia 14 . Vidigal et al 26 observed significant tubular atrophy and reduction of spermatogenesis in hMa that were administered finasteride.…”

Section: Discussionmentioning

confidence: 97%

Effect of finasteride on serum prostate-specific antigen (PSA) and on prostate of hamster Mesocricetus auratus (hMa)

et al. 2010

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Effect of finasteride on serum prostate-specific antigen (PSA) and on prostate of hamster Mesocricetus auratus (hMa) ABSTRACT Purpose: Evaluate the effects of finasteride on the serum PSA and on the prostate of hamster-Mesocricetus auratus(hMa). Methods: Twenty hMa male adults were split in groups control and experimental (n=10). Animals of the experimental group received 7.14ng/mL of finasteride, subcutaneously (SC) on the back three times per week, during 90 days. The finasteride dose was equivalent to 5.0mg administered to a 70kg man. At the end of the experiment the mean age for the animals in the control group was 15.2±1.13months and for the experimental group was 17.7±0.67 months. There was a statistically significant difference between mean ages of both groups (t value=5.98; p=0.001). The animals of the control group weighted 129.0±18.8g and the experimental group weighted 145.0±15.5g, t=1.88 e p=0.0514. The serum PSA was assessed through ELISA method. Prostates of those animals were collected and processed to histology and morphometry: the diameter of the acinous glands and the acinous epithelium, apoptosis, AgNORs and cellularity were assessed in both groups. Results: Serum PSA decreased in the experimental group, 0.003ng/mL versus 0.763ng/mL, H= 7.982 e p= 0.0047. Decrease in the acinous area occurred in animals that received finasteride, 238.000±24.600 µm 2 versus 398.600±55.320 µm 2 ; t= 2.653; p= 0.0122. A remarkable decrease in the area of the acinous epithelium occurred in the animals that received finasteride, 111.900±12.820 µm 2 versus 160.400±18.430 µm 2 t= 2.162; p= 0.0361. AgNORs were less expressed in finasteride treated animals, 2.846±0.877 versus 3.68 ±1.07 argyrophilic clusters for µm 2 , p= < 0.0001. Apoptosis was more intense in the experimental group, 53.62±1.389 than in controls, 14.76 ± 2.137, p= 0.0408. However, there was no statistical difference in the cellularity between both groups, 74.75±5.5 cells, in controls versus 65.07±13.24, in treated animals, p=0.5105. Conclusions: Use of finasteride decreased serum PSA and several histological parameters of the Hamster's prostate, such as lumen area, acinous and epithelium area, and AgNORs expression. Finasteride increased apoptosis in the prostate acinous cells although no significant difference in the cellularity could be found between the two groups of animals under study.

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The effect of finasteride on spermatogenesis of Mesocricetus auratus

Cited by 7 publications

References 9 publications

Reproductive and endocrinological effects of Benign Prostatic Hyperplasia and finasteride therapy in dogs

Reproductive and endocrinological effects of Benign Prostatic Hyperplasia and finasteride therapy in dogs

Does finasteride treatment for benign prostatic hyperplasia influence sperm DNA integrity in dogs?

Effect of finasteride on serum prostate-specific antigen (PSA) and on prostate of hamster Mesocricetus auratus (hMa)

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