The Effect of Glucose on Growth Hormone (GH)-Releasing Hormone-Mediated GH Secretion in Man*

Masuda, Akitsugu; Shibasaki, Tamotsu; Nakahara, M.; Imaki, Toshihiro; Kiyosawa, Yoshino; Jibiki, Kazuko; Demura, Hiroshi; Shizume, Kazuo; Ling, Nicholas

doi:10.1210/jcem-60-3-523

Cited by 103 publications

(36 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, the mechanism of the suppressing effect of hyperglycemia on GH secretion in normal subjects is not clear, nor is the cause of paradoxical secretion to oral glucose in acromegaly [13][14][15]. It was reported that an acromegaly induced by an ectopic GRHproducing tumor, had a paradoxical GH secretion to oral glucose, but that an exogenous GRH load did not induce GH secretion, therefore GRH was thought not to be involved in the paradoxical GH response to oral glucose load in acromegaly [16].…”

Section: Discussionmentioning

confidence: 99%

Glucose-Dependent Insulinotropic Polypeptide Induced Growth Hormone Secretion in Acromegaly

Umahara¹,

Okada

Ohshima

et al. 2003

Endocr J

View full text Add to dashboard Cite

Abstract. Glucose-dependent insulinotropic polypeptide (GIP), a peptide released from the intestines after meals, is thought to stimulate insulin secretion. GIP receptor cDNA has recently been cloned and its mRNA has been recognized in several organs including the pituitary, but the physiological roles of GIP receptors of the pituitary have yet to be determined. We have demonstrated the possibility that GIP stimulates GH secretions from the pituitary adenoma cells of acromegalics. GIP-stimulated GH responses were studied in four acromegalics. In two acromegalics whose GH showed paradoxical secretion to oral glucose tolerance test (OGTT), GIP infusion (0.6 mg/kg/h) drove GH secretion (13.7 to 68.1, 22.5 to 76.2 ng/ml, respectively). However, in the other two acromegalics whose GH showed no paradoxical response to OGTT, GIP infusion did not induce GH secretion. One of the patients who was studied extensively had a GH that responded to OGTT. This patient's serum GH levels increased after meals while adenomectomy abolished both the paradoxical GH secretions by OGTT and GH responses to the GIP infusion. These data suggested that some somatotroph adenoma cells have an aberrant response to GIP which may go toward explaining paradoxical GH secretions to OGTT in acromegalics.

show abstract

Section: Discussionmentioning

confidence: 99%

Glucose-Dependent Insulinotropic Polypeptide Induced Growth Hormone Secretion in Acromegaly

Umahara¹,

Okada

Ohshima

et al. 2003

Endocr J

View full text Add to dashboard Cite

show abstract

“…It is possible that hyperglycemia may itself affect GH secretion. An increased plasma glucose concentration exerted an inhibitory effect on the plasma GH response to GRF in man [26]. In rats hyperglycemia has been reported not to affect the GH response to GRF [27].…”

Section: Discussionmentioning

confidence: 87%

Inhibitory Effect of Volatile Fatty Acids on GRF-Induced GH Secretion in Sheep.

et al. 1993

View full text Add to dashboard Cite

Abstract. The effect of intravenous infusion of acetate, propionate and butyrate (0, 3, 10, 30 µmol kg-' min-1 over 40 min) on the secretion of growth hormone (GH), insulin and glucagon in response to growth hormone-releasing factor (GRF) injection (0.25 µg/kg, 10 min after the onset of acid infusion) was determined in six sheep. The intravenous injection of GRF caused a marked increase in plasma GH at every dose of each acid. The GH response to GRF was unaffected by an intravenous infusion of acetate. The basal plasma levels of insulin, glucagon and glucose were unchanged by acetate infusion. The infusion of propionate markedly suppressed the GH response to GRF in a dose-dependent manner. Propionate produced increases in plasma insulin, glucagon and glucose concentrations. Butyrate infusion also caused a significant attenuation of GRF-induced GH secretion. Butyrate infusion stimulated the secretion of both insulin and glucagon and caused hyperglycemia. After cessation of the infusion of propionate or butyrate plasma GH tended to increase again. Plasma somatostatin concentrations, which were measured only for the highest dose of butyrate, were unchanged during acid infusion, but increased on discontinuing the infusion. It is concluded that propionate and butyrate suppress GH secretion, while stimulating the secretion of insulin and glucagon in sheep.Key words: Growth hormone, Volatile fatty acids, Growth hormone-releasing factor, Sheep.( the rumen is metabolized in the rumen epithelium to produce ketone bodies and the remainder is oxidized in the liver [3]. Thus a basic role of VFA in ruminants is to meet a large proportion of their energy needs.In addition to the importance of VFA as an energy source for the animal, some attention has been paid to the effects of VFA on the secretion of metabolic hormones such as insulin and glucagon. Manns and Boda [4] first reported that butyrate and propionate injected intravenously enhanced insulin secretion in sheep. These observations have been confirmed by other workers [5]. Infusions of butyrate or propionate into the portal vein of sheep at rates producing portal plasma concentrations within the range observed after feeding caused increased insulin secretion, suggesting a

show abstract

“…Inhibition of GH response to GH-RH by high glucose was reported in healthy subjects after oral [13] or intravenous [14] administration of glucose. Thus, it is very interesting that a paradoxically high response of GH to GH-RH was observed in the H-R group even though the blood glucose concentration was much higher in the H-R group than in the L-R group.…”

Section: Discussionmentioning

confidence: 97%

Can We Predict Diabetic Complications by Examining GH Response to GH-RH Infusion Test in Patients with NIDDM?

et al. 1998

View full text Add to dashboard Cite

The Effect of Glucose on Growth Hormone (GH)-Releasing Hormone-Mediated GH Secretion in Man*

Cited by 103 publications

References 15 publications

Glucose-Dependent Insulinotropic Polypeptide Induced Growth Hormone Secretion in Acromegaly

Glucose-Dependent Insulinotropic Polypeptide Induced Growth Hormone Secretion in Acromegaly

Inhibitory Effect of Volatile Fatty Acids on GRF-Induced GH Secretion in Sheep.

Can We Predict Diabetic Complications by Examining GH Response to GH-RH Infusion Test in Patients with NIDDM?

Contact Info

Product

Resources

About