The Effect of High Concentrations of Histidine on the Level of Other Amino Acids in Plasma and Brain of the Mature Rat

Tyfield, Linda; Holton, John

doi:10.1111/j.1471-4159.1976.tb04442.x

Cited by 47 publications

(3 citation statements)

References 35 publications

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“…Therefore, a mechanism other than histamine could be involved in the histamine precursor, L-histidine-induced rota-rod performance of mice. Some reports corroborate this premise by demonstrating the property of L-histidine to alter the measures of other amino acids in the brain that can act as a precursor for the synthesis of serotonin, dopamine, norepinephrine, or GABA (Tyfield and Holton, 1976; Millan, 2003). Particularly, it has been described that the L-histidine metabolite imidazole acetic acid acts as an agonist on GABA A receptors (Haas et al ., 1973).…”

Section: Discussionmentioning

confidence: 89%

Stimulation of central histaminergic transmission attenuates diazepam-induced motor disturbance on rota-rod and beam walking tests in mice

Patel,

Jain

2024

Behavioural Pharmacology

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Diazepam administration has been shown to influence the release of histamine in various brain areas involved in motor behavior. Therefore, the present study explored the plausible regulatory role of the central histaminergic system in diazepam-induced deficits in motor performance in mice using the rota-rod and beam walking tests. In this study, several doses of diazepam (0.5, 1, 2, and 3 mg/kg, i.p.) were assessed in mice for changes in motor performance on the rota-rod and beam walking test. In addition, the brain histamine levels were determined after diazepam administration, and the diazepam-induced motor deficits were assessed in mice, pretreated centrally (intracerebroventricular) with histaminergic agents such as histamine (0.1, 10 µg), histamine precursor (L-histidine: 0.1, 2.5 µg), histamine neuronal releaser/H3 receptor antagonist (thioperamide: 0.5, 10 µg), H1 and H2 receptor agonist [2-(3-trifluoromethylphenyl) histamine (FMPH: 0.1, 6.5 µg; amthamine: 0.1, 5 µg)/antagonist (H1: cetirizine 0.1 µg) and (H2: ranitidine: 50 µg)]. Results indicate that mice treated with diazepam at doses 1, 2 mg/kg, i.p. significantly increased the brain histamine levels. Moreover, in mice pretreated with histaminergic transmission-enhancing agents, the diazepam (2 mg/kg, i.p.)-induced motor incoordination was significantly reversed. Contrastingly, diazepam (1 mg/kg, i.p.) in its subeffective dose produced significant motor deficits in mice preintracerebroventricular injected with histamine H1 and H2 receptor antagonists on both the employed tests. Therefore, it is postulated that endogenous histamine operates via H1 and H2 receptor activation to alleviate the motor-impairing effects of diazepam.

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Section: Discussionmentioning

confidence: 89%

Stimulation of central histaminergic transmission attenuates diazepam-induced motor disturbance on rota-rod and beam walking tests in mice

Patel,

Jain

2024

Behavioural Pharmacology

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“…It is activated by both Mg 2+ and Ca 2+ and has a K m in the millimolar range for ThTP. It is competitively inhibited by low concentrations of ATP and ADP, with IC 50 values of 20 µM for ATP and 75 µM for ADP [ 62 ]. These results suggest that the active site has a much higher affinity for adenine nucleotides than for thiamine compounds.…”

Section: Thiamine Triphosphatasesmentioning

confidence: 99%

Update on Thiamine Triphosphorylated Derivatives and Metabolizing Enzymatic Complexes

Bettendorff

2021

Biomolecules

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While the cellular functions of the coenzyme thiamine (vitamin B1) diphosphate (ThDP) are well characterized, the triphosphorylated thiamine derivatives, thiamine triphosphate (ThTP) and adenosine thiamine triphosphate (AThTP), still represent an intriguing mystery. They are present, generally in small amounts, in nearly all organisms, bacteria, fungi, plants, and animals. The synthesis of ThTP seems to require ATP synthase by a mechanism similar to ATP synthesis. In E. coli, ThTP is synthesized during amino acid starvation, while in plants, its synthesis is dependent on photosynthetic processes. In E. coli, ThTP synthesis probably requires oxidation of pyruvate and may play a role at the interface between energy and amino acid metabolism. In animal cells, no mechanism of regulation is known. Cytosolic ThTP levels are controlled by a highly specific cytosolic thiamine triphosphatase (ThTPase), coded by thtpa, and belonging to the ubiquitous family of the triphosphate tunnel metalloenzymes (TTMs). While members of this protein family are found in nearly all living organisms, where they bind organic and inorganic triphosphates, ThTPase activity seems to be restricted to animals. In mammals, THTPA is ubiquitously expressed with probable post-transcriptional regulation. Much less is known about the recently discovered AThTP. In E. coli, AThTP is synthesized by a high molecular weight protein complex from ThDP and ATP or ADP in response to energy stress. A better understanding of these two thiamine derivatives will require the use of transgenic models.

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“…R. Barchi и P. Braun [21] разграничили ТТРаз-ную и Mg 2+ -зависимую АТPазную (NTPазную) активность мембран мозга крысы, используя β-γ-метиленовый аналог ТТР, который снижал скорость ТТРазной реакции, но не оказывал влияния на гидролиз нуклеозидтрифосфатов. Было также показано, что АТP и АDP ингибиру-ют активность мембранной ТТРазы с K I соответ-ственно 20 и 75 мкМ [33]. Недавно были полу-чены свидетельства в пользу того, что ТТРазная активность синаптосомных мембран из мозга крысы, проявляющая рН-оптимум при рН 7,4, принадлежит тиаминсвязывающему протеину [9].…”

Section: результаты и обсуждениеunclassified

Properties of chicken liver membrane-associated thiamine triphosphatase

Ik¹,

Af²

2015

Ukr.Biochem.J.

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The Effect of High Concentrations of Histidine on the Level of Other Amino Acids in Plasma and Brain of the Mature Rat

Cited by 47 publications

References 35 publications

Stimulation of central histaminergic transmission attenuates diazepam-induced motor disturbance on rota-rod and beam walking tests in mice

Stimulation of central histaminergic transmission attenuates diazepam-induced motor disturbance on rota-rod and beam walking tests in mice

Update on Thiamine Triphosphorylated Derivatives and Metabolizing Enzymatic Complexes

Properties of chicken liver membrane-associated thiamine triphosphatase

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