The effect of highly selective vagotomy on canine gastric mucosal blood flow

Natsikas, Nick B.; Konstantaras, Christos; Psarrakos, Kyriakos P.; Kappas, Angelos M.; Lazarides, D.P.

doi:10.1007/bf01658314

Cited by 3 publications

(4 citation statements)

References 17 publications

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“…Studies made 3 weeks after vagotomy showed that blood flow had returned to normal basal levels, whereas acid secretion remained reduced [21,22]. Also, studies in dogs 6 months after HSV, using 99mTc, found that stimulated acid secretion to histamine was almost completely abolished, whereas blood flow was decreased by 50% [23]. If blood flow plays a permissive role in acid production, then a reduction in flow could explain the immediate reduction in acid output, but not the long-term effects of HSV.…”

Section: Significance Of Blood Flow Changes After Vagotomymentioning

confidence: 99%

Basal and dose‐response studies of gastric mucosal blood flow: Comparison of duodenal ulcer patients before and after highly selective vagotomy with normal volunteers

et al. 1982

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Gastric mucosal blood flow (neutral red clearance, NRC) and acid secretion were measured before and after highly selective vagotomy (HSV). Eleven patients with duodenal ulcer were studied before and 12–21 days after HSV. Eight volunteers were also studied using the histamine‐H2‐receptor antagonists cimetidine and ranitidine. Basal secretion was collected for 40–50 minutes and pentagastrin was given in increasing doses each for 40 minutes. Data were analyzed using Wilcoxon's signed‐ranks test for paired samples and an analysis of covariance. Basal NRC was similar both for patients and for volunteers and was unaffected by HSV. There was a linear correlation between NRC and acid output. The patients with duodenal ulcer had a lower ratio of NRC to acid during pentagastrin stimulation than was found in normal subjects, but the regression line after HSV was comparable to that found for the volunteers. Although stimulated acid output was reduced by HSV, NRC was significantly higher after HSV than before. The 2 histamine‐H2‐receptor antagonists reduced both NRC and acid to a similar extent, and this could not be overcome by increasing the dose of pentagastrin. These results indicate that mucosal blood flow and acid secretion may not be unconditionally linked, although a linear relationship was always found. HSV produces an effect on blood flow that is not linked to the reduction in acid output.

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Section: Significance Of Blood Flow Changes After Vagotomymentioning

confidence: 99%

Basal and dose‐response studies of gastric mucosal blood flow: Comparison of duodenal ulcer patients before and after highly selective vagotomy with normal volunteers

et al. 1982

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“…The results in this study are consistent with the findings in other studies. Investigations in animals using K 85 and 99m Tc clearance techniques, and the microsphere technique have demonstrated flow reductions in the stomach amounting to 50% after truncal vagotomy and PGV [3,15,16]. Intraoperative measurements with LDF before and after PGV have shown similar results along the devascularized part of the lesser curvature [17].…”

Section: Discussionmentioning

confidence: 95%

Effect of proximal gastric vagotomy on human gastric blood flow evaluated by endoscopic laser doppler flowmetry

1988

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The effect of proximal gastric vagotomy (PGV) on gastric blood flow has been evaluated endoscopically by laser Doppler flowmetry (LDF) in 12 patients with duodenal ulcer. The gastric wall circulation was examined at 7 defined positions in all subjects prior to surgery, 1 week postoperatively, and after 3 months. For comparison, 21 healthy volunteers were also examined by LDF. In all the investigated areas of the stomach, the blood flow values were lower in the unoperated duodenal ulcer patients than in the controls. In both groups, the blood circulation was significantly lower at the lesser curvature than at the greater curvature. Seven days after PGV, the blood flow was reduced 30% in the devascularized part of the lesser curvature. After 3 months, the flow values were similar to the preoperative ones. The gastric acid secretion was significantly reduced at 3 months. Postoperatively, one patient developed a gastric ulcer in the dissected area of the lesser curvature. This patient had lower flow values along the lesser curvature than the other patients after 7 days. The results of this study show that PGV leads to a temporary reduction of blood flow at the lesser curvature. This regional decrease in blood flow is probably not an important factor for the reduced acid secretion measured after PGV.

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mentioning

confidence: 99%

“…The effects of the various types of vagotomies on gastric blood flow have received considerable attention in the past [1][2][3][4][5][6][7]. More recently, several investigators have studied the effect of proximal gastric vagotomy on gastric mucosal blood flow in animals or patients with duodenal ulcer [5][6][7]. However, all these studies were performed with methods such as neutral red or pertechnate clearance, which do not permit separate measurements of mucosal blood flow in different regions of the stomach.…”

mentioning

confidence: 99%

Invited commentary

Cheung¹

1988

World j. surg.

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The effect of highly selective vagotomy on canine gastric mucosal blood flow

Cited by 3 publications

References 17 publications

Basal and dose‐response studies of gastric mucosal blood flow: Comparison of duodenal ulcer patients before and after highly selective vagotomy with normal volunteers

Basal and dose‐response studies of gastric mucosal blood flow: Comparison of duodenal ulcer patients before and after highly selective vagotomy with normal volunteers

Effect of proximal gastric vagotomy on human gastric blood flow evaluated by endoscopic laser doppler flowmetry

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