Surgical correction of refractive errors is becoming increasingly popular. In the 1990s, the excimer laser revolutionized the field of corneal refractive surgery with PRK and LASIK, and lately refractive lenticule extraction (ReLEx) of intracorneal tissue, using only a femtosecond laser, has become possible. Two new procedures were developed, ReLEx flex (FLEX) and ReLEx smile (SMILE).
Until this thesis, only a few long‐term studies of PRK with a relatively limited number of patients had been published; therefore, this thesis intended to retrospectively evaluate long‐term outcomes after PRK for all degrees of myopia for a large number of patients. Furthermore, a prospective contralateral eye study comparing FLEX and SMILE, when treating high to moderate degrees of myopia, had not been performed prior to this study. This was the second aim of this thesis.
In the first study, results from 160 PRK patients (289 eyes) were presented. Preoperative spherical equivalent ranged from −1.25 to −20.25 D, with 78% having low myopia (<−6 D). Average follow‐up time was 16 years (range 13–19 years), making this the longest published follow‐up study on PRK patients. Outcomes from eyes with low myopia were generally superior to outcomes from eyes with high myopia, at final follow‐up. Seventy‐two percent were within ±1.00 D of target refraction, as compared to 47% of eyes with high myopia. However, results from a subgroup of unilateral treated PRK patients indicated that refraction at final follow‐up was affected by myopic progression. Fifty percent of eyes with low myopia had uncorrected 20/20 distance visual acuity or better, as compared to 22% of eyes with high myopia. Haze did not occur if attempted corrections were <−4 D, and only eyes with high myopia lost two lines or more of CDVA (corrected distance visual acuity). Eighty‐one per cent were satisfied or very satisfied with their surgery.
Conclusion: The results support the continued use of the excimer laser for corneal surface ablation as a treatment option for correction of low degrees of myopia, and as the treatment of choice for subgroups of refractive patients (thin corneas, etc.). The results also highlight that treatment of higher degrees of myopia with standard PRK should only be done today under special circumstances, due to low refractive predictability, and high risk of corneal haze. Technological advances since then should be taken into account when comparing these results with contemporary techniques.
In the second study, 35 patients were randomized to receive FLEX in one eye and SMILE in the other. Preoperative spherical equivalent refraction ranged from −6 to −10 D with low degrees of astigmatism. A total of 34 patients completed the 6 month follow‐up period. Refractive and visual outcomes were very similar for the two methods, as well as tear film measurements and changes in corneal biomechanics. Ninety‐seven percent were within ±1.00 D of target refraction, no eyes lost two lines or more of CDVA, and contrast sensitivity was unaffected after both pro...