The Effect of Hyperbaric Oxygen Therapy on Erectile Functions: A Prospective Clinical Study

Şahin, Mehmet Oğuz; Şen, Volkan; Eser, Erhan; Koc, Evin; Gumus, U.; Karakuzu, Cengiz; Üçer, Oktay

doi:10.1159/000490356

Cited by 9 publications

(3 citation statements)

References 20 publications

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“…But although PDE5i is generally effective, it is associated with treatment failure in up to half the patients [7]. A good alternative treatment or adjunctive treatment for ED may be the hyperbaric oxygen therapy [8]. Diabetics suffer from refractory ED, especially vascular etiology, and there are difficult-to-treat patients and the efficacy of PDE5i is limited.…”

Section: Introductionmentioning

confidence: 99%

Erectile Dysfunction Treatment Using Focused Linear Low-Intensity Extracorporeal Shockwaves: Single-Blind, Sham-Controlled, Randomized Clinical Trial

Šrámková

Motil²,

Jarkovský

et al. 2019

Urol Int

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Introduction: Low-intensity extracorporeal shock wave therapy (Li-ESWT) is a new treatment modality for erectile dysfunction (ED). Our aim was to evaluate the treatment outcome of Li-ESWT for ED in single-blind, placebo controlled, randomized clinical trial. Methods: Sixty patients were randomized into 2 age-matched groups: Group A – treatment and Group B – placebo. Treatment consisted of 4 sessions on the PiezoWave2 unit (R. Wolf and ELvation Medical). Effectiveness was assessed according to the International Index of Erectile Function 5 (IIEF-5), Erectile Hardness Score (EHS), questions 2 and 3 of the Sexual Encounter Profile (SEP 2, SEP 3), and Global Assessment Question (GAQ) scores at baseline and 4 and 12 weeks after treatment. We evaluated patient’s and partner’s subjective satisfaction. Results: A statistically significant difference between the groups was found at 4 and 12 weeks after treatment with regard to the quality of erection as measured by the IIEF-5 (p = 0.049 and p < 0.001, respectively), the EHS after week 12 (p < 0.001), an increase in the EHS after 4 and 12 weeks (p = 0.030 and p < 0.001, respectively), after 12 weeks in GAQ (p < 0.001), SEP 2 (p = 0.05), SEP 3 (p < 0.001), and patient’s satisfaction (p < 0.001) and partner’s satisfaction (p < 0.001). Conclusions: The randomized single-blind study confirms that Li-ESWT significantly improves erectile function.

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Section: Introductionmentioning

confidence: 99%

Erectile Dysfunction Treatment Using Focused Linear Low-Intensity Extracorporeal Shockwaves: Single-Blind, Sham-Controlled, Randomized Clinical Trial

Šrámková

Motil²,

Jarkovský

et al. 2019

Urol Int

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“…Additionally, mean post-HBOT IIEF values for intercourse pleasure, orgasmic function, sexual desire, and overall satisfaction were all significantly higher than pre-HBOT scores. (8) There is also a case report that describes how HBOT was used to treat an open right foot wound on a male patient as part of a comprehensive wound management programme. The patient's medical history included Type 1 diabetes mellitus and chronic ED resistance to past PDE5I trials.…”

Section: )-Clinical Studiesmentioning

confidence: 99%

Hyperbaric oxygen therapy (HBOT) in andrological practice: A narrative review of the literature.

Ahmed

Hamid²,

Elsharkawy³

et al. 2023

Sohag Medical Journal

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Hyperbaric oxygen therapy (HBOT) is defined as the use of oxygen under pressure to increase oxygen levels in different tissues. Nowadays, HBOT is recommended as single therapy or in combination with other medical treatments like surgery or medicine for specific diseases. HBOT has a number of applications in emergency situations such carbon monoxide poisoning, envenomation from spider and snake bites, compartment syndrome, and central nervous system injury and also has a benefit in many chronic illness states like delayed wound healing. There are only a few publications on how HBOT affects erectile function, but many publications reported about its role in fournier's gangrene, radiation-induced cystitis, and interstitial cystitis that considered the principal indications of HBOT in genitourinary medicine. The rational of HBOT rely on how gases with different solubilities, particularly oxygen, behave in tissues and fluids under different pressures and volumes. Few reports about HBOT and erectile function in literature were found. HBOT is safe when performed following accepted standards except for minimal hazards.

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“…Accumulation of oxides in the ovarian tissues in older women may be one of the reasons for infertility, considering that it reduces the quality of embryos. In male infertility, sperm DNA fragmentation was improved after HBOT [ 14 ], and for male recover, erectile function has also been ameliorated [ 15 , 16 ]. On another hand, HBOT can significantly improve female endometrial receptivity in the cycle for better outcome of pregnancy implantation [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Hyperbaric Oxygen Treatment Ameliorates the Decline in Oocyte Quality and Improves the Fertility of Aged Female Mice

Zhong

Chen

et al. 2022

Reprod. Sci.

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The age-related decay in oocyte quality contributes to the gradual decline in fertility and the final occurrence of natural sterility. In this study, we aimed to investigate the effects of the hyperbaric oxygen treatment (HBOT) on oocyte quality in aging mouse oocyte. Eight- and forty-week-old female C57BL/6 J mice were treated with HBO for 10 days, and the quality of oocytes was analyzed. The results revealed that HBOT improved the age-related serum AMH levels. While compared with untreated aged mice, HBOT showed reduced follicular apoptosis and improved oocyte maturation, fertilization, and blastocyst formation in aged mice. HBO triggered changes in the microRNA expression in the ovaries of aged mice. In this study, 27 DEGs were identified in the HBOT mouse ovarian tissues, of which 9 were upregulated and 18 were downregulated. Notably, KEGG analysis revealed that these genes involved in different biological processes differed significantly in the ovary. Among these, the PI3K-Akt signaling was the most prominent pathway that controlled the recruitment and growth of primordial follicles. The calcium signaling pathway was found to be involved during the peri-implantation period. These results suggest that HBOT can be applied to improve the quality of oocytes, and it could be a potential clinical application to improve the fertility of aged female.

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The Effect of Hyperbaric Oxygen Therapy on Erectile Functions: A Prospective Clinical Study

Cited by 9 publications

References 20 publications

Erectile Dysfunction Treatment Using Focused Linear Low-Intensity Extracorporeal Shockwaves: Single-Blind, Sham-Controlled, Randomized Clinical Trial

Erectile Dysfunction Treatment Using Focused Linear Low-Intensity Extracorporeal Shockwaves: Single-Blind, Sham-Controlled, Randomized Clinical Trial

Hyperbaric oxygen therapy (HBOT) in andrological practice: A narrative review of the literature.

Hyperbaric Oxygen Treatment Ameliorates the Decline in Oocyte Quality and Improves the Fertility of Aged Female Mice

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