The effect of hyperbaric oxygen therapy on fracture healing in nicotinized rats

Demirtaş, Abdullah; Azboy, İbrahim; Bulut, Mehmet; Uçar, Bekir Yavuz; Alemdar, Celil; Alabalık, Ulaş; Akpolat, Veysi; Yıldız, İsmail; Ilgezdi, Savaş

doi:10.5505/tjtes.2014.52323

Cited by 9 publications

(8 citation statements)

References 28 publications

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“…HBOT is widely used in clinical practice. In plastic surgery, HBOT is regarded as a successful adjunctive therapy to promote wound healing, reduce inflammatory reactions, and improve flap survival (Zhang et al, 2007;Demirtaş et al, 2014). Keloid incisions are often vulnerable to infection after radiotherapy.…”

Section: Discussionmentioning

confidence: 99%

“…The pressure increases the level of oxygen in the blood plasma, which affects the immune system, wound healing, and vascular tone (O'Reilly et al, 2011). HBOT effectively promotes wound healing and reduces inflammatory reactions (Zhang et al, 2007;Demirtaş et al, 2014). According to our immunohistochemical studies, expression of the detected inflammatory factors (IL-6, HIF-1α, TNF-α, NF-κB, and VEGF) was lower in the R-O group than in the R-K group.…”

Section: Discussionmentioning

confidence: 99%

“…HBOT has been used to treat skin disease and infection. In plastic surgery, HBOT is regarded as a successful adjunctive therapy for promoting wound healing, reducing inflammatory reactions, and improving flap survival (Zhang et al, 2007;Demirtaş et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

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Hyperbaric oxygen therapy improves the effect of keloid surgery and radiotherapy by reducing the recurrence rate

Song

Liu

Zhang

et al. 2018

J. Zhejiang Univ. Sci. B

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Objective: Keloids are exuberant cutaneous scars that form due to abnormal growth of fibrous tissue following an injury. The primary aim of this study was to assess the efficacy and mechanism of hyperbaric oxygen therapy (HBOT) to reduce the keloid recurrence rate after surgical excision and radiotherapy. Methods: (1) A total of 240 patients were randomly divided into two groups. Patients in the HBOT group (O group) received HBOT after surgical excision and radiotherapy. Patients in the other group were treated with only surgical excision and radiotherapy (K group). (2) Scar tissue from recurrent patients was collected after a second operation. Hematoxylin and eosin (H&E) staining was used to observe keloid morphology. Certain inflammatory factors (interleukin-6 (IL-6), hypoxia-inducible factor-1α (HIF-1α), tumor necrosis factor-α (TNF-α), nuclear factor κB (NF-κB), and vascular endothelial growth factor (VEGF)) were measured using immunohistochemical staining. Results: (1) The recurrence rate of the O group (5.97%) was significantly lower than that of the K group (14.15%), P<0.05. Moreover, patients in the O group reported greater satisfaction than those in the K group (P<0.05). (2) Compared with the recurrent scar tissue of the K group, the expression levels of the inflammatory factors were lower in the recurrent scar tissue of the O group. Conclusions: Adjunctive HBOT effectively reduces the keloid recurrence rate after surgical excision and radiotherapy by improving the oxygen level of the tissue and alleviating the inflammatory process.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Hyperbaric oxygen therapy improves the effect of keloid surgery and radiotherapy by reducing the recurrence rate

Song

Liu

Zhang

et al. 2018

J. Zhejiang Univ. Sci. B

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“…Ueng et al, (9) in 1998 investigated the effect of HBOT on bone healing in rabbits and found that the torsional strength of lengthened tibia of HBOT group was increased significantly. Another study by Demirtas et al, (13) in 2014 found that the negative effects of nicotine on fracture healing in nicotinised rats are eliminated with hyperbaric oxygen therapy.…”

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confidence: 99%

Role of Hyperbaric Oxygen in Neo-Osteogenesis in Fractures of Long Bones

Panakkal¹,

M²

2019

Journal of Evolution of Medical and Dental Sciences

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BACKGROUND Hyperbaric Oxygen Therapy (HBOT) has been proved to regenerate and revitalize various tissues of the body. But, the role of HBOT in promoting neo-osteogenesis has been experimented mainly in animals. Clinical evidence to support or negate its effectiveness in humans for neo-osteogenesis is lacking due to non-availability of good quality trials. We wanted to assess the role of hyperbaric oxygen in neo-osteogenesis of the fractures of long bones. MATERIALS AND METHODS A randomised control trial was conducted in the Department of Orthopaedics in Indian Naval Hospital Ship Asvini from July 2006 to Mar. 2009. Patients requiring abundant callus for healing like comminuted fractures of long bones, treated by relative stability, fixation and those requiring bone transport, managed with the Ilizarov ring fixator are included in the study. 70 patients who met the selection criteria were randomly allotted to 2 groups with 35 patients each. Patients treated with no HBOT (n=29) as control group (Group 1) and patients treated with HBOT (n=34) as study group (Group 2) as 6 patients from control group and 1 patient from study group were lost to follow-up. Cases selected for trial were given HBOT with 100% oxygen for 45 minutes in a recompression chamber at 2 ATA for 3 weeks. The assessment of osteogenesis was done clinically, radiologically and sonologically at 3 weeks, 6 weeks, 12 weeks and thereafter 6 weekly, till fracture union. RESULTS At 3 weeks, sonological evidence of neo-osteogenesis was found in 55.9% of study group and 44.8% of control group. A similar result of clinical and early radiological evidence was noticed at 6 weeks of follow up. However, there was no significant difference in the neo-osteogenesis noticed between case and control group in the further follow up. CONCLUSION Our study failed to show any significant clinical evidence to support or refute the effectiveness of HBOT for the union of fractures. A clinical trial with large sample size is needed to define the role of HBOT in fracture healing, if any.

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“…HBO was first used in decompression sickness [14]. Subsequently, with understanding of the physiological and biomechanical effects, HBO has been widely used in the supplementary treatment for gas embolism, carbonmonoxide poisoning, diabetic foot ulcers, peripheral vascular diseases, thermal burns, skin grafts and flaps, purpura fulminista, osteomyelitis, osteoradionecrosis, cerebral and retinal oedema [15][16][17][18].…”

mentioning

confidence: 99%

Comparison of the effects of hyperbaric oxygen and extracorporeal shock wave therapy on healing in osteotendinousjunctional injuries: an experimental study of the rabbit model

Halil

Özkan

Akalın

et al. 2020

The European Research Journal

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Objectives: To biomechanically and histopathologically compare the effects on healing in the osteotendinous region of the treatment methods of hyperbaric oxygen (HBO) and extracorporel shock wave (ESW) on an injury created at the osteotendinous junction in an experimental rabbit model. Methods: The study included 36 New Zealand rabbits. The patellar tendon tibial osteotendinous junction was cut and then repaired. Group 1 was evaluated as the control group, with no further intervention. In Group 2, a single session of ESW was applied at 14 hz/750 Impulse/10 mins to an area 1×1 cm 2 in the repaired area under fluoroscopy guidance. The animals in Group 3 were applied with 100% oxygen as HBO at 2.4 ATA/110 min for 7 days. At the end of 6 weeks, 6 animals from each group were applied with a tension test and 6 animals were processed for histopathological examination. Results: In Group 1, the forces at the start of the separation of the osteotendinous junction, at a 2 mm separation and at full rupture were lower than those of Group 2 and Group 3 (p = 0.001 and p = 0.001, respectively). The highest separation force values were determined in Group 3 (p = 0.001). Histopathologically, a statistically significant difference was determined in respect of the fibrocartilage tisssue formation, and fusion with new bone tissue between Group 1 and Group 2 and between Group 1 and Group 3 (p < 0.05). No statistically significant difference was determined between Group 2 and Group 3 (p = 0.310). Conclusions: It was observed that the application of HBO and ESW improved biomechanical resistance and healing in the injuries in the osteotendinous junction by increasing the bone-tendon fusion in this area. The application of HBO and ESW increased biomechanical resistance compared to the control group.In the histopathological evaluation, the ESW group was better than the control group and the HBO group was evaluated as the best.

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The effect of hyperbaric oxygen therapy on fracture healing in nicotinized rats

Abstract: BACKGROUND:The aim of the present study was to investigate the effect of hyperbaric oxygen therapy on fracture healing in nicotinized rats.

Cited by 9 publications

References 28 publications

Hyperbaric oxygen therapy improves the effect of keloid surgery and radiotherapy by reducing the recurrence rate

Hyperbaric oxygen therapy improves the effect of keloid surgery and radiotherapy by reducing the recurrence rate

Role of Hyperbaric Oxygen in Neo-Osteogenesis in Fractures of Long Bones

Comparison of the effects of hyperbaric oxygen and extracorporeal shock wave therapy on healing in osteotendinousjunctional injuries: an experimental study of the rabbit model

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