The Effect of Hyperbaric Oxygen Therapy On acute Wound Healing in Rabbits: An experimental Study and Histopathological Analysis

Abstract

Background:The goal of our research is to show the effects and impacts of hyperbaric oxygen therapy (HBOT) on acute model wounds in animal subjects.Methods: Three experimental groups were created using injured rabbits (N=36)-randomly divided into three groups (N=12 per group). One group was treated only with standard wound care management. Two groups were additionally treated with HBOT either once or twice a day. The wounds were surgical, uninfected, and in healthy animal test subjects. We compared the immunohistochemical and histological parameters in 4-, 7-and 10-day intervals.Results: The detection of epidermal leaf parameters, the number of microabscesses, the Histopathological Superficial Epithelium Healing Score, Connective Tissue Healing Score, Histopathological Acute Inflammation Score and Total Histopathological Wound Healing Score all showed significant changes between time intervals within the individual groups. Conclusion:The results did not show that HBOT had a significant effect on the healing process of uncomplicated acute wounds.