The effect of hyperbaric oxygen therapy on the survival of random pattern skin flaps in nicotine-treated rats

Selçuk, Caferi Tayyar; Kuvat, Samet Vasfi; Bozkurt, Mehmet; Yaşar, Zeki; Gülsün, Niyazi; Ilgezdi, Savaş; Ula, Mahmut; Özalp, Burhan

doi:10.1016/j.bjps.2011.11.015

Cited by 22 publications

(22 citation statements)

References 29 publications

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“…Fourteen studies investigated HBOT for chronic wounds, 12 studies investigated HBOT in acute wounds, one study investigated HBOT in both chronic and acute wounds and two studies were performed in experimental wound models. Eighteen studies (62%) showed at least one or more significant positive outcomes …”

Section: Resultsmentioning

confidence: 99%

Oxygen therapies and their effects on wound healing

Smet

Kroese

Menon

et al. 2017

Wound Repair Regeneration

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Oxygen is an important factor for wound healing. Although several different therapies investigated the use of oxygen to aid wound healing, the results of these studies are not unequivocal. This systematic review summarizes the clinical and experimental studies regarding different oxygen therapies for promoting wound healing, and evaluates the outcomes according the methodological details. A systematic literature search was conducted using Embase, Medline, Web of Science, Cochrane, PubMed publisher, and Google Scholar libraries. Clinical and experimental studies investigating oxygen for wound healing were selected. Included articles were categorized according to the kind of therapy, study design, and wound type. The methodological details were extracted and analyzed. Sixty-five articles were identified and divided in three different oxygen therapies: Local oxygen therapy, hyperbaric oxygen therapy, and supplemental inspired oxygen therapy. More than half of the included local oxygen and hyperbaric oxygen studies had one or more significant positive outcomes, 77 and 63%, respectively. Supplemental inspired oxygen therapy during gastrointestinal and vascular surgery was more likely to have a positive result than during other surgical interventions reducing surgical site infections. These many positive outcomes promote the use of oxygen treatment in the stimulation of wound healing. However, the lack of clinical studies and vast methodological diversity made it impossible to perform a proper comparison within and between the different therapies. Further randomized clinical studies are warranted to examine the value of these therapies, especially studies that investigate the more patient-friendly oxygen dressings and topical wound oxygen therapies. Also, to achieve more solid and consistent data, studies should use more standardized methods and subjects.

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Section: Resultsmentioning

confidence: 99%

Oxygen therapies and their effects on wound healing

Smet

Kroese

Menon

et al. 2017

Wound Repair Regeneration

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“…22083-74-5) (2 mg/kg, twice a day subcutaneously) [16,17] and in Groups 2 and 4, saline solution (1 ml, twice a day subcutaneously) were administered.…”

Section: Methodsmentioning

confidence: 99%

The effect of hyperbaric oxygen therapy on fracture healing in nicotinized rats

Demirtaş

Azboy

Bulut

et al. 2014

Ulus Travma Acil Cerrahi Derg

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“…The main pharmacological action of nicotine is the activation of the sympathetic nervous system. Nicotine in tobacco products causes peripheral vasoconstriction and tissue ischemia and decreases oxygen tension (Selcuk et al, 2012). Intravenous nicotine produces dose-related increases in heart-rate and blood pressure.…”

Section: Discussionmentioning

confidence: 99%

The Effects of Systemic Use of Nicotine on the Rat Nasal Mucosa: a Histopathologic and Immunohistochemical Study

et al. 2012

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SUMMARY:The objective of this study was to evaluate the histopathologic effects of systemic use of nicotine on the rat nasal mucosa. Twelve adult Sprague-Dawley rats weighing 180-220 g, were used as experimental animals. The rats were divided into Nicotine and control groups. The rats of Nicotine groups (n=6) were administered 2mg/kg Nicotine sulphate for 28 days. The rats of control group (n=6) were only administered 1,5 ml physiologic saline solution subcutaneously for 28 days. All animals were sacrified at the end of the study and nasal tissue samples were removed and prepared for histologic examination. The sections were stained with Hematoxylin and Eosin (H-E) and Periodic acid-Schiff (PAS) and Trichrome-Masson were observed under light microscope. E-cadherin immunreactivity of pseudostrafied epithelial cells of nasal mucosa was assessed by immunohistochemical staining. There were significant differences in average histopathological score between the groups treated and non-treated to nicotine. In nicotine group, degenerative change of epithelial cells and hypertrophy of goblet cells were observed. Leukocytes infiltration was observed in significant areas of connective tissue. Ecadherin expression was significantly decreased in epithelial cells of the nasal mucosa of Nicotine group.

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The effect of hyperbaric oxygen therapy on the survival of random pattern skin flaps in nicotine-treated rats

Cited by 22 publications

References 29 publications

Oxygen therapies and their effects on wound healing

Oxygen therapies and their effects on wound healing

The effect of hyperbaric oxygen therapy on fracture healing in nicotinized rats

The Effects of Systemic Use of Nicotine on the Rat Nasal Mucosa: a Histopathologic and Immunohistochemical Study

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