The effect of hypericum perforatum on kidney ischemia/reperfusion damage

Çakır, Murat; Düzova, Halil; Baysal, Işil; Gül, Cemile Ceren; Kuşcu, Gülbahar; Kutluk, Fatma; Çakin, Hilal; Şeker, Şifanur; İlbeği, Esranur; Uslu, Seda; Avcı, Umut; Demır, Serpıl; Akinci, Cihan; Atli, Sercan

doi:10.1080/0886022x.2017.1287734

Cited by 23 publications

(17 citation statements)

References 39 publications

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“…The increase in pro-inflammatory cytokines may relate to the damage of renal cell structure caused by oxidative stress and lipid peroxidation. Consistently, previous studies revealed that CTX-induced nephrotoxicity resulted in the enhancement of pro-inflammatory cytokines [7,26,39]. However, numerous studies supported that inflammatory factor inhibition plays an indispensable role in the prevention of CTX-mediated renal injury [6,37].…”

Section: Discussionsupporting

confidence: 65%

Protective Effect of Low Molecular Weight Peptides from Solenocera crassicornis Head against Cyclophosphamide-Induced Nephrotoxicity in Mice via the Keap1/Nrf2 Pathway

et al. 2020

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The major component of the Solenocera crassicornis head protein hydrolysates-fraction 1 (SCHPs-F1) are low molecular weight peptides (MW < 1 kDa). In this study, we investigated the potential renoprotective effects of SCHPs-F1 in a cyclophosphamide (CTX) toxicity mouse model. In brief, 40 male mice were randomly divided into 5 groups and received either saline or 80 mg/kg body weight (BW) CTX by intraperitoneal injection for 5 days, followed by either saline or SCHPs-F1 (100, 200, and 400 mg/kg BW) by intragastric administration for 15 days. SCHPs-F1 treatment significantly reversed the CTX-induced decreases in the levels of blood urea nitrogen (BUN), creatinine (CRE), and cytochrome P450 (CYP450), as well as the renal histological lesions. Furthermore, the results indicated that SCHPs-F1 potentially alleviated CTX-induced nephrotoxicity through mitigating inflammatory responses, oxidative stress, and apoptosis status of the kidneys, as evidenced by decreased levels of malondialdehyde (MDA), interleukin (IL)-1β, IL-6, tumor necrosis factor (TNF)-α, and interferon (IFN)-γ and increased levels of total antioxidant capacity (T-AOC), catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px). Moreover, overexpression of pro-apoptotic proteins pair B-cell lymphoma-2 (Bcl-2)-associated X (Bax)/Bcl-2, cysteinyl aspartate specific proteinase (caspase)-3 and caspase-9 in renal tissues were suppressed by treatment with SCHPs-F1. In addition, the protein levels of the antioxidant factor nuclear factor erythroid-2 related factor 2 (Nrf2) and the expression levels of its downstream target genes heme-oxygenase (HO-1), glutamate-cysteine ligase modifier subunit (GCLM) and NAD(P)H dehydrogenase (quinone) 1 (NQO-1) were stimulated by treatment with SCHPs-F1 in the CTX-induced renal injury model. Taken together, our data suggested that SCHPs-F1 could provide a novel potential strategy in mitigating the nephrotoxicity caused by CTX.

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Section: Discussionsupporting

confidence: 65%

Protective Effect of Low Molecular Weight Peptides from Solenocera crassicornis Head against Cyclophosphamide-Induced Nephrotoxicity in Mice via the Keap1/Nrf2 Pathway

et al. 2020

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“…Patients poisoned with paraquat may suffer multiple organ dysfunction of the heart, liver, lungs and kidney (38). BUN is an indicator that reflects kidney function, while PaCO 2 and Lac are important indexes reflecting respiratory function and lung injury (39)(40)(41). The present study hypothesized that miR-27a may be involved in kidney and lung injury in patients with MODS induced by paraquat poisoning.…”

Section: Discussionmentioning

confidence: 84%

Clinical significance of serum levels of microRNA‑27a and its correlation with interleukin‑10 in patients with multiple organ dysfunction syndrome caused by acute paraquat poisoning

Dai

Zhang

et al. 2020

Exp Ther Med

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The aims of the present study were to examine the clinical significance of serum microRNA-27a (miR-27a) levels in patients with multiple organ dysfunction syndrome (MODS) caused by acute paraquat poisoning and to investigate the correlation between miR-27a and interleukin (IL)-10. A total of 82 patients with MODS induced by acute paraquat poisoning and 88 healthy controls were recruited in the present study. Reverse transcription-quantitative PCR was used to measure serum miR-27a expression levels in patients with MODS and the control group. IL-10 serum levels were determined using ELISA. Decreased serum miR-27a level and increased IL-10 expression levels were detected in patients with paraquat poisoning compared with healthy controls (P<0.001). A moderately negative correlation was identified between the serum expression levels of miR-27a and IL-10 (r=-0.5225; P<0.001). miR-27a expression level was found to be associated with blood urea nitrogen, partial pressure of carbon dioxide, arterial blood lactic acid, and the acute physiology and chronic health evaluation II score (APACHE II; P<0.05). The area under the curve for miR-27a was 0.946, with a sensitivity of 86.6% and specificity of 87.5% at a cutoff value of 2.10. The non-survival patient group had lower miR-27a expression levels compared with the survival group (P<0.01). Multivariate Cox regression analyses suggested miR-27a expression level and APACHE II score were independent prognostic factors for 30-day mortality (P<0.01). The present results suggested that serum miR-27a level may be a potential novel diagnostic and prognostic factor for MODS caused by paraquat poisoning. Collectively, miR-27a may be involved in the process of MODS induced by paraquat poisoning by regulating the inflammatory response.

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“…The researchers determined that markers of oxidative stress and lipid peroxidation induced by hyperlipidemia were significantly decreased by systemic HP administration. Furthermore, HP treatment reduced the MDA levels and increased the SOD, CAT, and GSH-PX activity in rats with kidney ischemia/reperfusion damage [40]. In a clinical study, Naziroglu et al [41] investigated the effects of HP on oxidative stress in serum and leukocytes of patients with multiple sclerosis, and reported that the lipid peroxidation level in the HP-incubated neutrophil were markedly decreased in those patients.…”

Section: Discussionmentioning

confidence: 99%

Palatal Mukozal Hasar Oluşturulan Tavşanlarda Profilaktik Hypericum Perforatum Yağ Uygulamasının Antioksidan Özellikleri

Günpınar

Kiliç²,

Tosun³

et al. 2020

Celal Bayar Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi

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Bu çalışma, tavşanlarda tedavi öncesi (t) topikal Hypericum perforatum (HP) yağı uygulamasının antioksidan ve yumuşak doku yara iyileştirici özelliklerini belirlemek amacıyla yapıldı. Gereç ve Yöntem: Otuz altı Yeni Zelanda albino tavşanı, rastgele olarak t-HP yağı (test, n = 18) ve t-zeytin yağı (kontrol, n = 18) gruplarına ayrıldı. Test ve kontrol gruplarındaki tavşanların her biri cerrahi öncesi topikal olarak HP veya zeytinyağı ile ön işleme tabi tutuldu. Alınan dişeti biyopsileri, re-epitelizasyon (RE) ve granülasyon dokusu olgunlaşması (GTM) açısından analiz edildi. Genel yara görünümü, eritem ve epitelyal birleşme skorlaması yapılarak klinik görünüm değerlendirildi. VEGF ve FGF-2 düzeyleri immünohistokimyasal olarak analiz edildi. Doku katalaz (CAT) ve malondialdehid (MDA) seviyeleri ELISA yöntemi ile belirlendi. Tüm değerlendirmeler cerrahi sonrası 3., 7. ve 14. günlerde gerçekleştirildi. Bulgular: t-HP yağı uygulaması yapılan grupta, t-zeytinyağı uygulaması yapılan gruba göre daha yüksek epitelyal birleşme (7. günde) ve genel yara görünüm skorları (7. ve 14. günlerde) tespit edildi (p <0.05). Diğer taraftan, RE skorları gruplar arasında farklı değildi (p>0.05). Pozitif olarak boyanmış FGF-2 hücrelerinin sayısı, test grubunda kontrol grubundan daha yüksekti (p <0.05), ancak gruplar arasında pozitif boyanmış VEGF damar sayısı açısından anlamlı bir fark yoktu (p>0.05). t-HP yağı uygulaması, t-zeytinyağı uygulamasına göre doku CAT seviyelerini arttırırken, doku MDA seviyelerini düşürdü (p <0.05). Sonuç: Bu çalışmadan elde edilen sonuçlar, topikal HP yağının tedavi öncesi uygulanmasının antioksidan etkilere sahip olduğunu, taşıyıcısı olan zeytinyağı ile karşılaştırıldığında sekonder yara iyileşmesini hızlandırmak amacıyla kullanılabileceğini göstermiştir.

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The effect of hypericum perforatum on kidney ischemia/reperfusion damage

Cited by 23 publications

References 39 publications

Protective Effect of Low Molecular Weight Peptides from Solenocera crassicornis Head against Cyclophosphamide-Induced Nephrotoxicity in Mice via the Keap1/Nrf2 Pathway

Protective Effect of Low Molecular Weight Peptides from Solenocera crassicornis Head against Cyclophosphamide-Induced Nephrotoxicity in Mice via the Keap1/Nrf2 Pathway

Clinical significance of serum levels of microRNA‑27a and its correlation with interleukin‑10 in patients with multiple organ dysfunction syndrome caused by acute paraquat poisoning

Palatal Mukozal Hasar Oluşturulan Tavşanlarda Profilaktik Hypericum Perforatum Yağ Uygulamasının Antioksidan Özellikleri

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