The effect of Terminalia chebula extract vs. silver sulfadiazine on burn wounds in rats

Abstract

The results of this study showed that T. chebula extract was capable of accelerating wound healing in rats by wound contraction, and had beneficial effects more than SSD 1% cream in the management of burn injury.

The Role of Phytochemicals in the Inflammatory Phase of Wound Healing

“…Supporting this concept, increased wound healing in streptozotocin-induced diabetic rats with the topical application of T. chebula extract has been shown [84]. Moreover, T. chebula extract accelerates wound healing in burn wounds in comparison to 1% silver sulfadiazine in rat models [85]. …”

Evaluation of cytotoxic, immunomodulatory and antibacterial activities of aqueous extract from leaves of Conocarpus erectus Linnaeus (Combretaceae)

“…ointment promotes significant wound healing in rats, ethanol extract of T. chebula Retz. accelerated wound healing in burn wounds of rats, semipurified fraction containing gallic acid from T. chebula Retz. showed antiageing activity and ethanol extract from fruit of this same plant protected skin against UVB photodamage .…”

Effects of Silver Sulfadiazine and Adibderm® Herbal Ointments in Treatment of Patients with Second Degree Burns: A Randomized Clinical Trial

“…Nasiri et al, compared the effect of AE and SSD ointments on burn wounds recovery in mice, and concluded that recovery had a higher rate in the 10% AE ointment group. Compared to other groups, the collagen generated at the area of wound in the 10% AE ointment group was a horizontal high-quality type (20). Examining the effect of AE ointment in a human model, Nasiri et al, concluded that AE ointment was better than SSD in terms of efficiency and low side effects to treat second degree burns (14).…”