The effect of insulin pump combined with ulinastatin on the levels of PCT, TG, PTX-3, and CX3CL1 in patients with diabetic ketoacidosis and pancreatitis

Wei, Dongmei; Yin, Chao; Lu, Songtao; Xiong, Juwen; Zhu, Lishuang; Yan, Shaoru; Meng, Rui

doi:10.1097/md.0000000000025141

Cited by 5 publications

(6 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the present study, UTI intervention was used to reduce the incidence rate of total 30-day mortality and MODS. Wei [29] reported that an insulin pump combined with UTI can shorten the recovery time of clinical symptoms and reduce the levels of inflammatory factors after diabetic ketoacidosis complicated with pancreatitis. Xubijing combined with UTI can improve the outcome, decrease the inflammatory response, and promote the recovery of the patient’s immune function and liver function in traumatic brain injury.…”

Section: Discussionmentioning

confidence: 99%

Effects of ulinastatin therapy in emergency severe multiple trauma: A single-center randomized controlled trial

Xu¹,

Jiao²,

Zhang³

et al. 2023

Medicine

View full text Add to dashboard Cite

Background: Severe multiple traumas are one of the most common diseases and carry a significant financial burden with high disability and mortality. There are no effective drugs in the clinical management of severe multiple traumas, and there is an absence of evidence-based medicine concerning the treatment of severe multiple traumas.Methods: The present study explored whether ulinastatin (UTI) can improve the outcome of severe multiple traumas. The present research included patients who were hospitalized in intensive care units after being diagnosed with severe multiple trauma. Patients received UTIs (400,000 IU) or placebos utilizing computer-based random sequencing (in a 1:1 ratio). The primary outcome measures were 30-day mortality, multiple organ dysfunction syndrome, inflammatory response, coagulation function, infection, liver function, renal function, and drug-related adverse effects.Results: A total of 239 individuals were classified into 2 groups, namely, the placebo group (n = 120) and the UTI group (n = 119). There were no statistically significant differences in baseline clinical data between the 2 groups. The 30-day mortality and multiple organ dysfunction syndrome in the UTI group were remarkably improved compared with those in the placebo group. UTI can protect against hyperinflammation and improve coagulation dysfunction, infection, liver function, and renal function. UTI patients had markedly decreased hospitalization expenditures compared with the placebo group. Conclusion:The findings from the present research indicated that UTIs can improve the clinical outcomes of patients with severe multiple traumas and have fewer adverse reactions.

show abstract

Section: Discussionmentioning

confidence: 99%

Effects of ulinastatin therapy in emergency severe multiple trauma: A single-center randomized controlled trial

Xu¹,

Jiao²,

Zhang³

et al. 2023

Medicine

View full text Add to dashboard Cite

show abstract

“…Conclusions from these research reports should be treated with caution, however, because of their limited sample sizes or retrospective nature. Conversely, Wei et al [ 38 ] reported that after diabetic ketoacidosis complicated with AP, the recovery period of clinical symptoms and the levels of inflammatory mediators may be reduced by using an insulin pump in conjunction with UTI. Thus, the current investigation approved a large single-center RCT to verify the therapeutic benefits of UTI in severe AP.…”

Section: Discussionmentioning

confidence: 99%

Ulinastatin in the treatment of severe acute pancreatitis: A single-center randomized controlled trial

Wang¹,

Jiao²,

Zhang³

et al. 2023

World J Clin Cases

View full text Add to dashboard Cite

BACKGROUND Severe acute pancreatitis (AP) is one of the most common diseases of the gastrointestinal tract and carries a significant financial burden with high disability and mortality. There are no effective drugs in the clinical management of severe AP, and there is an absence of evidence-based medicine concerning the treatment of severe AP. AIM To explore whether ulinastatin (UTI) can improve the outcome of severe AP. METHODS The present research included patients who were hospitalized in intensive critical care units (ICUs) after being diagnosed with severe AP. Patients received UTI (400000 IU) or placebos utilizing computer-based random sequencing (in a 1:1 ratio). The primary outcome measures were 7-d mortality, clinical efficacy, inflammatory response, coagulation function, infection, liver function, renal function, and drug-related adverse effects were evaluated. RESULTS A total of 181 individuals were classified into two groups, namely, the placebo group ( n = 90) and the UTI group ( n = 91). There were no statistically significant differences in baseline clinical data between the two groups. The 7-d mortality and clinical efficacy in the UTI group were remarkably improved compared with those in the placebo group. UTI can protect against hyperinflammation and improve coagulation dysfunction, infection, liver function, and renal function. UTI patients had markedly decreased hospital stays and hospitalization expenditures compared with the placebo group. CONCLUSION The findings from the present research indicated that UTI can improve the clinical outcomes of patients with severe AP and has fewer adverse reactions.

show abstract

“…The evaluation criteria of clinical efficacy were as follows [9,10] . Markedly effective: all clinical symptoms disappeared, fasting blood glucose <11.1 mmol/L, pH was 7.35 to 7.45, serum bicarbonate was 22 to 28 mmol/L, urine ketone body was negative, and blood ketone body <0.3 mmol/L.…”

Section: Methodsmentioning

confidence: 99%

“…The evaluation criteria of clinical efficacy were as follows. [9,10] Markedly effective: all clinical symptoms disappeared, fasting blood glucose <11.1 mmol/L, pH was 7.35 to 7.45, serum bicarbonate was 22 to 28 mmol/L, urine ketone body was negative, and blood ketone body <0.3 mmol/L. Effective: Partial clinical symptoms improved, fasting blood glucose <16.7 mmol/ L, pH was 7.35 to 7.45, serum bicarbonate was 22 to 28 mmol/L, urine ketone body was negative, and blood ketone body <0.3 mmol/L.…”

Section: Observation Indexesmentioning

confidence: 99%

Effects of nutritional support combined with insulin therapy on serum proteins, inflammatory factors, pentraxin-3, and serum amylase levels in patients with diabetic ketoacidosis complicated with acute pancreatitis

Yin

Wei

et al. 2021

Medicine

View full text Add to dashboard Cite

To explore the effects of nutritional support combined with insulin therapy on serum protein, procalcitonin (PCT), C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), pentraxin-3 (PTX-3), and serum amylase (AMS) levels in patients with diabetic ketoacidosis complicated with acute pancreatitis. A total of 64 patients with diabetic ketoacidosis complicated with acute pancreatitis admitted to our hospital from January 2018 to February 2019 were enrolled in this prospective study. They were divided into the study group and the control group according to the random number table method, with 32 patients in each group. Patients in the study group were given nutritional support combined with insulin therapy, and patients in the control group were given insulin therapy. There were no significant differences in general data including age, gender, body mass index, course and type of diabetes, acute physiology and chronic health evaluation II, RANSON, CT grades between the 2 groups before treatment (all P > .05). After 7 days of treatment, the clinical efficacy of the study group was significantly higher than that of the control group (study group vs control group, 94.44% vs 75.00%, P < .05). After 7 days of treatment, the levels of prealbumin and albumin in the study group were significantly higher than those in the control group ( P < .05). After 7 days of treatment, the levels of PCT, CRP, TNF-α, PTX-3, and AMS in the 2 groups were significantly lower than those before treatment ( P < .05), and the levels of PCT, CRP, TNF-α, PTX-3, and AMS in the study group were significantly lower than those in the control group. After 7 days of treatment, the levels of IgG, IgM, and IgA in the 2 groups were significantly higher than those before treatment, and the levels of IgG, IgM, and IgA in the study group were significantly higher than those in the control group ( P < .05). Nutritional support combined with insulin is obviously effective in the treatment of diabetic ketoacidosis complicated with acute pancreatitis, which can improve serum protein levels, reduce inflammatory response, improve immune function, and is worthy of clinical application.

show abstract

The effect of insulin pump combined with ulinastatin on the levels of PCT, TG, PTX-3, and CX3CL1 in patients with diabetic ketoacidosis and pancreatitis

Cited by 5 publications

References 15 publications

Effects of ulinastatin therapy in emergency severe multiple trauma: A single-center randomized controlled trial

Effects of ulinastatin therapy in emergency severe multiple trauma: A single-center randomized controlled trial

Ulinastatin in the treatment of severe acute pancreatitis: A single-center randomized controlled trial

Effects of nutritional support combined with insulin therapy on serum proteins, inflammatory factors, pentraxin-3, and serum amylase levels in patients with diabetic ketoacidosis complicated with acute pancreatitis

Contact Info

Product

Resources

About