The Effect of Interleukin 38 on Inflammation-induced Corneal Neovascularization

Zhu, Jiangli; Zhang, Jing; Wang, Yan; Chen, Jianping; Li, Xiaopeng; Liu, Xiangling; Kong, Eryan; Su, Shao Bo; Zhang, Zhongjian

doi:10.2174/1566524019666190627122655

Cited by 7 publications

(4 citation statements)

References 43 publications

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“…IL‐38 can inhibit endothelial cell proliferation and migration via reducing the expression of angiogenic factors. Also, IL‐38 can decrease the expression of IL‐8 and TNF‐α to limit the activation of angiogenesis 34–38 . Wei et al 39 showed that IL‐38 inhibited the inflammatory response in the infarcted heart, and inflammatory cardiomyocytes inhibited apoptosis and alleviated ventricular remodeling through the release of IL‐38 40 .…”

Section: Role Of Ll‐38 In Related Diseasesmentioning

confidence: 99%

“…Also, IL‐38 can decrease the expression of IL‐8 and TNF‐α to limit the activation of angiogenesis. 34 , 35 , 36 , 37 , 38 Wei et al 39 showed that IL‐38 inhibited the inflammatory response in the infarcted heart, and inflammatory cardiomyocytes inhibited apoptosis and alleviated ventricular remodeling through the release of IL‐38. 40 Although reperfusion therapy was an effective method to address coronary occlusion, excessive myocardial ischemia‐reperfusion injury remains existed.…”

Section: Role Of Ll‐38 In Related Diseasesmentioning

confidence: 99%

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The emerging role of IL‐38 in diseases: A comprehensive review

Chen,

Xi,

et al. 2023

Immunity Inflam & Disease

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IntroductionInterleukin‐38 (IL‐38) is a new type of anti‐inflammatory cytokine, which is mainly expressed in the immunity‐related organs and is involved in various diseases including cardiovascular and cerebrovascular diseases, lung diseases, viral infectious diseases and autoimmune diseases.AimThis review aims to detail the biological function, receptors and signaling of IL‐38, which highlights its therapeutic potential in related diseases.ConclusionThis article provides a comprehensive review of the association between interleukin‐38 and related diseases, using interleukin‐38 as a keyword and searching the relevant literature through Pubmed and Web of science up to July 2023.

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Section: Role Of Ll‐38 In Related Diseasesmentioning

confidence: 99%

Section: Role Of Ll‐38 In Related Diseasesmentioning

confidence: 99%

The emerging role of IL‐38 in diseases: A comprehensive review

Chen,

Xi,

et al. 2023

Immunity Inflam & Disease

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“…The polarization of macrophages to M1 type will release inflammatory factors such as IL-6, TNF-α, and IL-1. Among these pro-angiogenic molecules, IL-6 is a pro-inflammatory cytokine produced in corneal chemical burn tissue, which is known to induce the production of angiogenic factors to promote CNV [ 11 , 13 , 36 ]. TNF-α, which is mainly synthesized by macrophages, also plays a key role in inflammatory diseases, increasing the expression of adhesion molecules and inflammatory mediators in human corneal epithelial cells, and recruiting leukocytes by producing chemokines [ 37 ].…”

Section: Discussionmentioning

confidence: 99%

Impaired Autophagy Causes Severe Corneal Neovascularization

Yang

Yuan

et al. 2022

Cells

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Purpose: To investigate the role of macrophage autophagy in the process of corneal neovascularization (CNV). Methods: In vivo, mice CNV was induced by alkali injury and compared with rapamycin-treated alkaline burn mice. Western blot was used to determine the autophagic status of the macrophages. We quantified the levels of macrophage polarization markers (CD86, INOS, CD163, CD206) by RT-qPCR and measured inflammatory factors through ELISA (IL-6 and TNF-α) in the early phase after injury. In vitro, the human umbilical vein endothelial cells (HUVECs) were co-cultured with macrophage-conditioned medium (MCM) induced by the THP-1 cell line to simulate the neovascular microenvironment. The vascularization capacity of HUVECs was examined using the CCK-8 assay kit, tube formation assay, and scratch wound-healing assay. Results: In vivo, the mRNA expression of Beclin-1 and ATG5 was increased, together with the upregulation of M1 macrophage markers (CD86 and INOS) in corneas after early alkali injury. The area of CNV is effectively relieved in the rapamycin-treated mice. In vitro, upregulation of autophagy level by pretreatment with 3-methyladenine (3-MA) could increase the mRNA expression of the M1 markers. Macrophage-conditioned medium with impaired autophagy contains more IL-6 and TNF-α compared to the M1 macrophage-conditioned medium, promoting HUVEC proliferation, migration, and tube formation capacity. Enhancing the autophagy level with rapamycin (RAPA) could reverse this phenomenon. Conclusions: Impaired autophagy promoted macrophage polarization toward M1 type and increased the expression of IL-6 and TNF-α, which led to severe CNV. Using the autophagy activator (RAPA) could effectively alleviate CNV by promoting autophagy.

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“…It has been interrogated that if IL-38 is topically administrated in the injured cornea of the mentioned model, inflammation-induced angiogenesis is diminished. IL-38 is capable of attenuating thee secretion of IL-1β, IL-6, IL-8, and TNF-α cytokines and reducing angiogenesis-related activities (e.g., proliferation, migration, and tube formation of human retinal endothelial cells) [153].…”

Section: Role Of Il-38 In Inflammatory Disorders Inflammation-induced Corneal Neovascularizationmentioning

confidence: 99%

Immunobiological Properties and Clinical Applications of Interleukin-38 for Immune-Mediated Disorders: A Systematic Review Study

Esmaeilzadeh

Bahmaie

Nouri

et al. 2021

IJMS

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Exponential growth in the usage of “cytokines” (as seroimmunobiomarkers) has facilitated more accurate prognosis, early diagnosis, novel, and efficient immunotherapeutics. Numerous studies have reported immunopathophysiological and immunopathological processes of interleukin-38 (IL-38). Therefore, in this systematic review article, the authors aimed to present an updated comprehensive overview on the immunobiological mechanisms, diagnostic, and immune gene-based therapeutic potentials of IL-38. According to our inclusion and exclusion criteria, a total of 216 articles were collected from several search engines and databases from the January 2012 to July 2021 time interval by using six main keywords. Physiologic or pathologic microenvironments, optimal dosage, and involved receptors affect the functionalities of IL-38. Alterations in serum levels of IL-38 play a major role in the immunopathogenesis of a wide array of immune-mediated disorders. IL-38 shows anti-inflammatory activities by reduction or inhibition of pro-inflammatory cytokines, supporting the therapeutic aspects of IL-38 in inflammatory autoimmune diseases. According to the importance of pre-clinical studies, it seems that manipulation of the immune system by immunomodulatory properties of IL-38 can increase the accuracy of diagnosis, and decipher optimal clinical outcomes. To promote our knowledge, more collaboration is highly recommended among laboratory scientists, internal/infectious diseases specialists, oncologists, immunologists, diseases-specific biomarkers scientists, and basic medical researchers.

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The Effect of Interleukin 38 on Inflammation-induced Corneal Neovascularization

Cited by 7 publications

References 43 publications

The emerging role of IL‐38 in diseases: A comprehensive review

The emerging role of IL‐38 in diseases: A comprehensive review

Impaired Autophagy Causes Severe Corneal Neovascularization

Immunobiological Properties and Clinical Applications of Interleukin-38 for Immune-Mediated Disorders: A Systematic Review Study

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