The effect of Khat (Catha edulis) as an appetite suppressant is independent of ghrelin and PYY secretion

Murray, Charles; Roux, Carel W. le; Emmanuel, Anton; Halket, John M.; Przyborowska, A.; Kamm, Michael A.; Murray‐Lyon, Iain M.

doi:10.1016/j.appet.2008.06.012

Cited by 48 publications

(46 citation statements)

References 14 publications

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“…Neste contexto, crescem em importância estudos para o desenvolvimento de novas alternativas terapêuticas eficazes e acessíveis às populações de baixa renda, sendo as plantas medicinais aliadas extremamente úteis, pois fornecem extratos e compostos químicos isolados, cujas capacidades anorexígena e hipolipidêmica vêm sendo demonstradas em inúmeros trabalhos científicos de várias partes do mundo (Kidwai & Upreti, 1993;Jorge et al, 1998;Heerden et al, 2007;Lei et al, 2007;Xie et al, 2007;Bahramikia & Yazdanparast, 2008;Cardozo et al, 2008;Harnafi et al, 2008;Murray et al, 2008;Ming et al, 2009).…”

Section: Introductionunclassified

Levantamento etnobotânico de plantas utilizadas como anti-hiperlipidêmicas e anorexígenas pela população de Nova Xavantina-MT, Brasil

Silva¹,

Melo²,

Ribeiro³

et al. 2010

Rev. bras. farmacogn.

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RESUMO:O presente trabalho verificou a utilização de plantas medicinais encontradas no Cerrado mato-grossense para o tratamento de hiperlipidemias e obesidade. Entrevistas com 180 pessoas acima de 50 anos foram realizadas em Nova Xavantina-MT. O questionário abordou nome popular, parte utilizada, forma de preparo e uso das espécies citadas, além de informações gerais sobre o uso de plantas. -Hil.). A folha foi a parte mais utilizada (46%) e o preparo das plantas ocorre principalmente por meio de infusão citado por 36,5% dos entrevistados. Apesar do uso popular destas plantas no combate as hiperlipidemias e obesidade, há necessidade de estudos fitoquímicos e farmacológicos que comprovem estas atividades, com vistas ao desenvolvimento de um fitoterápico.Unitermos: Levantamento etnobotânico, Nova Xavantina, plantas medicinais, anti-hiperlipidêmicas, anorexígenas, Cerrado.ABSTRACT: "Ethnobotanical survey of plants used as anti-hyperlipidemic and anorexigenic by the population of Nova Xavantina-MT, Brazil". This study checked the use of medicinal plants found in the Cerrado mato-grossense for the treatment of hyperlipidemia and obesity. Interviews with 180 people over 50 years were held in Nova Xavantina-MT. The questionnaire addressed popular name, part used, type of preparation and use of the species mentioned, beyond general information about the use of plants. The ten plants most cited were collected, identified and studied through a literature review. Most respondents (95.6%) said using medicinal plants regularly, while 71.5% of them inherited the knowledge of plants of parents and grandparents and 94.20% reported the use to advise youngsters. Furthermore, 93.6% attested that the plants are more effective than the drugs from pharmacy and 57% considered the strong effect of the same, i.e., they always solved health problems. Regarding adverse effects, 95.9% said they have never felt them after the use of plants. Of the respondents, 56.7% knew or had used medicinal plants in the treatment of hyperlipidemias and obesity, being cited 54 medicinal species belonging to 53 different genera and 38 families, with emphasis on Fabaceae (13%

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Section: Introductionunclassified

Levantamento etnobotânico de plantas utilizadas como anti-hiperlipidêmicas e anorexígenas pela população de Nova Xavantina-MT, Brasil

Silva¹,

Melo²,

Ribeiro³

et al. 2010

Rev. bras. farmacogn.

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“…9 Cathinone is also thought to be behind the anorexigenic effect of khat, which contributes to the decreased appetite and body weight observed in khat chewers. 10 The First Gulf Registry of Acute Coronary Events (Gulf RACE-1) has recently shown that khat chewing (confined mainly to patients in Yemen) was associated with increased in-hospital risk of stroke and death in patients with acute coronary syndrome (ACS) compared with non-khat chewers who were mainly from different Gulf populations. 11 Mateen and Casino 1 in an accompanying editorial suggested that this increased risk of complications may be attributed in part to variations in income and access to health care between the different Gulf populations studied.…”

Section: Clinical Perspective On P 2689mentioning

confidence: 99%

Acute Coronary Syndrome and Khat Herbal Amphetamine Use

Ali

Habib²,

Al‐Motarreb³

et al. 2011

Circulation

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Background— The khat plant is a stimulant similar to amphetamine and is thought to induce coronary artery spasm. Khat is widely chewed by individuals originating from the Horn of Africa and the Arabian Peninsula. The aim of this study was to evaluate the clinical characteristics and outcome of khat chewers presenting with acute coronary syndrome. Methods and Results— From October 1, 2008, through June, 30, 2009, 7399 consecutive patients with acute coronary syndrome were enrolled in the Second Gulf Registry of Acute Coronary Events (Gulf RACE-2). Nineteen percent of patients were khat chewers; 81% were not. Khat chewers were older, more often male, and less likely to have cardiovascular risk factors. Khat chewers were less likely to have a history of coronary artery disease and more likely to present late and to have higher heart rate and advanced Killip class on admission. Khat chewers were more likely to present with ST-segment–elevation myocardial infarction. Overall, khat chewers had higher risk of death, recurrent myocardial ischemia, cardiogenic shock, ventricular arrhythmia, and stroke compared with non–khat chewers. After adjustment for baseline variability, khat chewing was found to be an independent risk factor of death and for recurrent ischemia, heart failure, and stroke. Conclusions— Our data confirm earlier observations of worse in-hospital outcome among acute coronary syndrome patients who chew khat. This worse outcome persists up to 1 year from the index event. This observational report underscores the importance of improving education concerning the cardiovascular risks of khat chewing.

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“…In a study on healthy volunteers, it was observed that khat chewing decreased hunger and increased fullness scores. This was associated to a prolonged gastric emptying which was significant when compared to lettuce chewing [70].…”

Section: Catha Edulis (Khat)mentioning

confidence: 97%

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2016

JNHFE

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The effect of Khat (Catha edulis) as an appetite suppressant is independent of ghrelin and PYY secretion

Cited by 48 publications

References 14 publications

Levantamento etnobotânico de plantas utilizadas como anti-hiperlipidêmicas e anorexígenas pela população de Nova Xavantina-MT, Brasil

Levantamento etnobotânico de plantas utilizadas como anti-hiperlipidêmicas e anorexígenas pela população de Nova Xavantina-MT, Brasil

Acute Coronary Syndrome and Khat Herbal Amphetamine Use

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