The Effect of Kiwifruit Therapeutics in the Treatment of Diabetic Foot Ulcer

Abstract

Diabetes mellitus is considered a silent disease with possible late chronic complications such as diabetic foot ulcer. This condition is managed by surgical debridement. To improve surgical outcome, some surgeons use proteolytic agents after surgery. Kiwifruit contains a type of proteolytic enzyme called actinidin that may play a role in the treatment of such complication. In the current study, we evaluate the role of kiwifruit extract in the treatment of diabetic foot ulcer. Eighteen diabetic foot ulcer patients were included in a randomized, double-blind clinical trial. The patients were divided randomly to control and experimental groups. Patients in the control group underwent daily wound dressing using base ointment (Eucerin). In the experimental group, we added kiwifruit extract to the standard wound dressing. Clinical data including general appearance of wound (according to recorded photographs before and after medical intervention) were analyzed using SPSS version 22. The mean wound area of the experimental group was significantly less than in the control group ( P = .005) after 4 weeks of treatment. Comparison of the average of size difference, before and after the treatment in the experimental group and the control group, shows that kiwifruit can have a good impact on wound healing ( P = .0001). In patients with diabetic foot ulcer, wound dressing using kiwifruit extract may help reduce time of treatment and may replace surgical debridement for some selected cases.

Gastroprotective Effects of Spirulina platensis, Golden Kiwifruit Flesh, and Golden Kiwifruit Peel Extracts Individually or in Combination against Indomethacin-Induced Gastric Ulcer in Rats

“…In that regard, ultimate biological activities toward specific diseases could be approached to recommend dietetic therapy application. There are rare or no available publications about using kiwifruit as a gastro-protective agent despite efficient application in the treatment of diabetic foot ulcers [18,19]. Kiwifruit had higher total flavonoids, total chlorophyll, carotenoids, and vitamin C [20][21][22][23].…”

“…Interestingly, there is no available information on the antiulcerogenic activity of SP and kiwifruit individually or in combination against peptic ulcers. However, even though the literature showed promising potentialities related to the use of SP and kiwifruit [18] separately, the gastroprotective potential of SP and kiwifruit both individually or in combination needs to be carefully investigated. Moreover, literature has mainly reviewed the antiulcerogenic efficiency of golden kiwifruit in Swiss albino mice [24], but the antiulcerogenic and gastroprotective potential of golden kiwifruit, their peels, and SP individually and/or in combination has not been studied so far, thus motivating this work.…”

Production of Plant Proteases and New Biotechnological Applications: An Updated Review

“…Promising studies have been indicated that actinidin could be used for diabetes mellitus due to its ability to degrade α‐amylase [259] . Furthermore, the topical administration of kiwifruit for 4 weeks could heal diabetic ulcers in patients [260] . StSBTc‐3 is a cucumisin‐like protease obtained from Solanum tuberosum with the capacity to inhibit platelet aggregation without cytotoxic activity on human erythrocytes agent.…”

“…[259] Furthermore, the topical administration of kiwifruit for 4 weeks could heal diabetic ulcers in patients. [260] StSBTc-3 is a cucumisin-like protease obtained from Solanum tuberosum with the capacity to inhibit platelet aggregation without cytotoxic activity on human erythrocytes agent. Therefore, StSBTc-3 shows potential to be used in the treatment of thromboembolic disorders such as strokes, pulmonary embolism, and deep vein thrombosis.…”

Terapias Inovadoras Para Reparo Tecidual Em Pessoas Com Pé Diabético

“…O Diabetes Mellitus (DM) é uma doença crônica silenciosa de importância mundial e considerada um grave problema de saúde pública, por promover diversas complicações preocupantes, como o pé diabético (1) , que se caracteriza por uma úlcera nos membros inferiores agravada por uma infecção. O pé diabético se origina de problemas relacionados às diversas áreas suscetíveis da doença, como nervos, pele, vasos e sistema músculo esquelético dos pés (2) .…”