The effect of (L‐)carnitine on weight loss in adults: a systematic review and meta‐analysis of randomized controlled trials

Abstract

This study provides a systematic review and meta-analysis of randomized controlled trials, which have examined the effect of the carnitine on adult weight loss. Relevant studies were identified by systematic search of PubMed, Embase, Cochrane Central Register of Controlled Trials and reference lists of relevant marker studies. Nine studies (total n = 911) of adequate methodological quality were included in the review. Trials with mean difference (MD) of 95% confidence interval (CI) were pooled using random effect model. Results from meta-analysis of eligible trials revealed that subjects who received carnitine lost significantly more weight (MD: -1.33 kg; 95% CI: -2.09 to -0.57) and showed a decrease in body mass index (MD: -0.47 kg m(-2) ; 95% CI: -0.88 to -0.05) compared with the control group. The results of meta-regression analysis of duration of consumption revealed that the magnitude of weight loss resulted by carnitine supplementation significantly decreased over time (p = 0.002). We conclude that receiving the carnitine resulted in weight loss. Using multiple-treatments meta-analysis of the drugs and non-pharmacotherapy options seem to be insightful areas for research. © 2016 World Obesity.

Comment on ‘The effect of (l‐)carnitine on weight loss in adults: a systematic review and meta‐analysis of randomized controlled trials’

“…Recently, Pooyandjoo et al , published an interesting article concerning the use of ( l ‐)carnitine on weight loss. We had an optimistic impression that an accessible nutritional supplement – the ( l‐ )carnitine – could, in fact, contribute to weight loss, even in small amounts of 1.33 kg (95% CI = −2.09 a − 0.57).…”

Efeitos ergogênicos da L-carnitina no metabolismo lipídico

“…Porém, houve um fator limitante com a falta de mensuração de indicadores de oxidação lipídica (WALL, et al 2011). Também, uma revisão sistemática e meta-análise de ensaios clínicos randomizados, que examinaram nove estudos sobre o efeito da L-carnitina sobre a perda de peso de adultos, apontou que os indivíd uos que suplementaram a substância, perderam significativamente mais peso e diminuíra m mais o índice de massa corporal, em comparação ao grupo controle (POOYANDJOO, et al 2016). Além disso, foi também mensurado que a perda de peso favorecida pela L-carnitina diminui ao longo do tempo (POOYANDJOO, et al 2016).…”

“…Também, uma revisão sistemática e meta-análise de ensaios clínicos randomizados, que examinaram nove estudos sobre o efeito da L-carnitina sobre a perda de peso de adultos, apontou que os indivíd uos que suplementaram a substância, perderam significativamente mais peso e diminuíra m mais o índice de massa corporal, em comparação ao grupo controle (POOYANDJOO, et al 2016). Além disso, foi também mensurado que a perda de peso favorecida pela L-carnitina diminui ao longo do tempo (POOYANDJOO, et al 2016). Da mesma forma, um estudo envolve ndo mulheres com síndrome do ovário policístico, realizado durante 12 semanas com suplementação diária de 250mg de Lcarnitina, apontou que ao final do experimento, a administração da substância resultou numa significativa redução de peso em comparação com o placebo (SAMIMI, et al 2016).…”

Role or Synergistic Interaction of Adenosine and Vitamin D3 Alongside High-Intensity Interval Training and Isocaloric Moderate Intensity Training on Metabolic Parameters: Protocol for an Experimental Study (Preprint)

“…Presently, one of the most challenging issues in the field of pharmacy is the discovery of the most effective anti-obesity intervention with the least negative side effects on humans. Recently, researchers have focused on the effect of most active forms of vitamin D and have shown its controlling role in the incidence of obesity [13][14][15][16][17].…”

“…Plant based substances [4,10,11] and medicines [12][13][14][15][16] have been proposed as strategic treatment and preventive measures for obesity. Presently, one of the most challenging issues in the field of pharmacy is the discovery of the most effective anti-obesity intervention with the least negative side effects on humans.…”