The effect of L-thyroxine replacement therapy on ischemia-modified albümin and malondialdehyde levels in patients with overt and subclinical hypothyroidism

Abstract

Increased MDA levels in both patient groups represent increased lipid peroxidation which might play an important role in the pathogenesis of the atherosclerosis seen in these patients. Increased OS in patients with SHypo and OHypo could be improved by LT treatment. Also, MDA can be used as a reliable marker of OS and oxidative damage, while IMA is considered to be inappropriate.

A meta-analysis of the association of serum ischaemia-modified albumin levels with human hypothyroidism and hyperthyroidism

“…We found 15 studies related to IMA in thyroid diseases [ 15 – 23 , 25 – 28 , 37 – 38 ]. Non-english articles on IMA in thyroid disorders were not found.…”

“…Finally, a total of 12 studies [ 15 – 23 , 28 , 37 – 38 ] fulfilled the selection criteria were included for further analysis, regardless of IMA measurement method and units. All studies, except two [ 19 , 28 ], presented IMA results in absorbance units (ABU).…”

“…All included studies reported serum IMA concentrations in the healthy control group and in one or more groups of thyroid disorders. Meta-analysis of IMA in HT included 12 studies with a total of 417 patients and 471 controls [ 15 , 17 , 19 , 20 , 23 , 28 , 37 – 38 ]. And, the meta-analysis of IMA in HYT included six studies with a total of 207 patients and 202 controls [ 16 , 19 – 22 ].…”

“…Similarly, the meta-analysis on pre- and post-treatment IMA values were performed on three independent observations from two studies in HT group [ 19 , 38 ]. One study contained treatment data on two different groups (overt and subclinical HT), which were considered independently [ 38 ]. Thus, three studies were considered in this comparison.…”

“… ? Not studied Colorimetric, serum (ABU) Age and sex 5 Dahiya et al, 2014/India [ 15 ] 50 (5/45) 38.1 ± 11.8 22.3 ± 1.9 HT 50 (4/46) 37.9 ± 13.6 32.4 ± 2.1 Newly diagnosed Not studied Colorimetric, serum (ABU) Age and sex 6 Erem et al, 2016/Turkey [ 38 ] 30 (9/21) 51.6 ± 17.04 26.53 ± 3.2 HT 30 (6/24) 46.3 ± 14.34 26.33 ± 3.16 3.17 Studied Colorimetric, serum (ABU) Age, sex, BMI and BP 8 SHT 25 (8/17) 47.72 ± 13.6 27.08 ± 3.27 2.92 Erem et al, 2015/Turkey [ 16 ] 30 (9/12) 51.6 ± 17.0 26.5 ± 3.2 HYT 45 (12/33) 50.5 ± 18.0 25.0 ± 3.5 2.4 years Studied Colorimetric, serum (ABU) Age and BMI 8 SHYT 20 (3/17) 56.1 ± 19.3 ...…”