The effect of lactose micro-spherical crystals prepared by conditioning with supercritical fluid on salbutamol sulphate inhalation performance

Muhammad, Syed Anuar Faua ad Syed; Tang, Patricia A.; Chan, Hak‐Kim; Dehghani, Fariba

doi:10.1016/j.supflu.2012.07.013

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Sugars and Polyols Carriers For Dpi1

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Cited by 9 publications

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“…Lactose crystals formed by scCO 2 method showed satisfactory FPF (40 ± 0.3%) for SS when determined using the Aerolizer® at a flow rate of 28.3 l/min. This was considerably superior to that of commercial coarse grade lactose which was found to be 38% [ 33 ].…”

Section: Sugars and Polyols Carriers For Dpimentioning

confidence: 99%

Imagine the Superiority of Dry Powder Inhalers from Carrier Engineering

Mehta

2018

Journal of Drug Delivery

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Inhalation therapy has strong history of more than 4000 years and it is well recognized around the globe within every culture. In early days, inhalation therapy was designed for treatment of local disorders such as asthma and other pulmonary diseases. Almost all inhalation products composed a simple formulation of a carrier, usually α-lactose monohydrate orderly mixed with micronized therapeutic agent. Most of these formulations lacked satisfactory pulmonary deposition and dispersion. Thus, various alternative carrier's molecules and powder processing techniques are increasingly investigated to achieve suitable aerodynamic performance. In view of this fact, more suitable and economic alternative carrier's molecules with advanced formulation strategies are discussed in the present review. Furthermore, major advances, challenges, and the future perspective are discussed.

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Section: Sugars and Polyols Carriers For Dpimentioning

confidence: 99%