The effect of lithium on thyroid function in patients with bipolar disorder.

Kraszewska, Agnieszka; Abramowicz, Maria; Chłopocka-Woźniak, M; Sowiński, Jerzy; Rybakowski, Janusz

doi:10.12740/pp/21684

Cited by 19 publications

(13 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Pathogenesis of Graves’ disease (GD). * viral and bacterial infections, iodine, stress, medications, external radiation, radioactive iodine, toxins, selenium and vitamin D3 deficiency, lymphopenia, smoking, CD8+ T lymphocyte deficiency [5,6,7,8,9,10,11]. …”

Section: Figurementioning

confidence: 99%

Does the Epstein–Barr Virus Play a Role in the Pathogenesis of Graves’ Disease?

Pyzik

Grywalska

Matyjaszek‐Matuszek

et al. 2019

IJMS

View full text Add to dashboard Cite

Graves’ disease (GD) it the most common chronic organ-specific thyroid disorder without a fully recognized etiology. The pathogenesis of the disease accounts for an interaction between genetic, environmental, and immunological factors. The most important environmental factors include viral and bacterial infections. The Epstein-Barr virus (EBV) is one of the most common latent human viruses. Literature has suggested its role in the development of certain allergic and autoimmune diseases. EBV also exhibits oncogenic properties. The aim of the study was to analyze and compare the presence of EBV DNA in peripheral blood mononuclear cells (PBMCs) in patients with newly recognized GD and to find a correlation between EBV infection and the clinical picture of GD. The study included 39 untreated patients with newly diagnosed GD and a control group of 20 healthy volunteers who were gender and age matched. EBV DNA was detected with reverse transcription polymerase chain reaction (RT PCR) assay. The studies showed a significantly higher incidence of EBV copies in PBMCs among GD patients compared to the control group. Whereas, no significant correlations were found between the incidence of EBV copies and the evaluated clinical parameters. Our results suggest a probable role of EBV in GD development. EBV infection does not affect the clinical picture of Graves’ disease.

show abstract

Section: Figurementioning

confidence: 99%

Does the Epstein–Barr Virus Play a Role in the Pathogenesis of Graves’ Disease?

Pyzik

Grywalska

Matyjaszek‐Matuszek

et al. 2019

IJMS

View full text Add to dashboard Cite

show abstract

“…In bipolar disorder, the thyroid function should be examined in the context of a role of the thyroid gland and the hypothalamic-pituitary-thyroid axis in the pathophysiology of this illness. The most frequent side effects associated with longitudinal lithium administration are goiter and hypothyroidism (Kraszewska et al, 2014 ). We studied 137 patients with bipolar disorder, including 98 subjects (30 male, 68 female) receiving lithium for at least 3 years (mean 19 + 10 years) and 39 subjects (12 male, 27 female) never receiving lithium, The groups were matched for age and the duration of illness.…”

Section: The Adverse Effects Of Long-term Lithium Treatment and Theirmentioning

confidence: 99%

Challenging the Negative Perception of Lithium and Optimizing Its Long-Term Administration

Rybakowski

2018

Front. Mol. Neurosci.

View full text Add to dashboard Cite

The use of lithium for the prevention of recurrences in mood disorders has a 55-year history. Nowadays, lithium is universally accepted as the first-choice mood-stabilizer (MS) for maintenance treatment of bipolar disorder. In addition to its mood-stabilizing properties, lithium exerts anti-suicidal, immunomodulatory and neuroprotective action which may further substantiate its clinical usefulness. Despite these facts, the use of lithium in mood disorders has been greatly underutilized. The reasons include the introduction and promoting other MS as well as a perception of lithium as a “toxic drug” due to its side effects, mainly thyroid, renal and cognitive disturbances. The trends in lithium prescription in recent decades show relative stability or a decline at the expense of other mood-stabilizing drugs, both first generation (valproate) and second generation (olanzapine, quetiapine, lamotrigine). In this review article, the negative perception of lithium by some clinicians will be challenged. First, the data showing lithium superiority over other MS will be presented. Second, the lithium-induced side effects which can make a challenge for a more frequent application of this drug will be delineated, and their proper management described. Finally, an issue of benefits of long-term administration of lithium will be discussed, including the phenomenon of the “excellent lithium responders” (ER) as well as a subject of starting lithium prophylaxis early in the course of the illness. This review article is based on the 47-year experience with lithium therapy by the author of the article.

show abstract

“…Previous study found that hypothalamic-pituitary-thyroid (HPT) axis abnormalities play an important role in the pathophysiology and treatment of BD [18]. Researchers also found that hyperthyroidism may increase the risk of developing BD [19].…”

Section: Introductionmentioning

confidence: 99%

Correlation between Intrinsic Brain Activity and Thyroid-Stimulating Hormone Level in Unmedicated Bipolar II Depression

et al. 2019

View full text Add to dashboard Cite

Background/Aims: Although abnormalities of amplitude of low-frequency fluctuations (ALFF) and hormone levels of hypothalamus-pituitary-thyroid axis have been reported in patients with bipolar disorder (BD), the association between abnormal ALFF and serum thyroid hormone levels remains unknown. Method: A total of 90 patients with unmedicated BD II depression and 100 healthy controls (HCs) underwent resting-state functional magnetic resonance imaging, and then routine band (0.01–0.1 Hz), slow-5 band (0.01–0.027 Hz), and slow-4 band (0.027–0.073 Hz) ALFF analysis were performed. Additionally, serum thyroid hormone levels including free tri-iodothyronine (FT3), total tri-iodothyronine (TT3), free thyroxin (FT4), total thyroxin (TT4), and thyroid-stimulating hormone (TSH) were detected. The correlation between abnormal serum thyroid hormone levels and ALFF values in patients with BD II depression was calculated. Results: Compared with the HCs, patients with BD II depression showed decreased ALFF in bilateral precuneus (PCu)/posterior cingulate cortex (PCC) in routine and slow-4 frequency bands, decreased ALFF in the right PCu, and increased ALFF in the right middle occipital gyrus (MOG) in the slow-5 frequency band. Additionally, patients with BD II depression showed lower TSH level than HCs, and TSH level was positively correlated with ALFF values in the bilateral PCu/PCC in the routine frequency band. Conclusions: These findings suggest that patients with BD II depression display intrinsic activity abnormalities, mainly in the PCu/PCC and MOG, which are associated with specific frequency bands. Moreover, altered intrinsic activity in the PCu/PCC may be related to TSH levels in bipolar II depression.

show abstract

The effect of lithium on thyroid function in patients with bipolar disorder.

Cited by 19 publications

References 55 publications

Does the Epstein–Barr Virus Play a Role in the Pathogenesis of Graves’ Disease?

Does the Epstein–Barr Virus Play a Role in the Pathogenesis of Graves’ Disease?

Challenging the Negative Perception of Lithium and Optimizing Its Long-Term Administration

Correlation between Intrinsic Brain Activity and Thyroid-Stimulating Hormone Level in Unmedicated Bipolar II Depression

Contact Info

Product

Resources

About