The Effect of Local Melatonin Application Following the Removal of an Impacted Mandibular Third Molar

Refahee, Shaimaa Mohsen; Aboulmagd, Inass Abdelrahaman; Ali, Reham Ragab Abd Rabbou; Aziz, Omniya Abdel; Ahmed, Walaa Abd el Aty; Shabaan, Alshaimaa Ahmed

doi:10.1016/j.joms.2023.01.010

Cited by 3 publications

(1 citation statement)

References 38 publications

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“…Melatonin exhibits anti-inflammatory properties that potentially contribute to its analgesic effects. The perception of pain is influenced by inflammation, and the potential reduction of inflammation by melatonin may have analgesic effects [ 20 , 21 ]. The modulation of pain signaling is a complex process that involves the interaction of various neurotransmitter systems responsible for pain regulation [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

Impact of Melatonin as a Premedication Agent in Caesarean Section on Blood Loss and Postoperative Pain Level

Alkhfaji,

Kahloul,

Askar

et al. 2023

Anesthesiology Research and Practice

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Background. Postpartum hemorrhage (PPH) is a serious postdelivery condition with a high incidence of morbidity and mortality for women who undergo childbirth with or without a caesarean section. Melatonin has been suggested to increase the contractility of myometrium and reduce the pain score postoperatively, therefore it is believed that the use of melatonin before surgery may decrease blood loss, reduce pain score, and decrease the need for postoperative opioids. Objectives. The main objectives of this study are focused on the investigation of melatonin as a premedication agent to reduce blood loss and decrease pain score postoperatively in patients undergoing cesarean section under spinal anesthesia. Methods. 80 patients were scheduled for spinal anesthesia-based cesarean sections and randomly assigned to two groups, melatonin group (M) 40 patients and placebo group (P) 40 patients to receive either 10 mg of sublingual melatonin or a placebo of 90 minutes preoperatively. Hemoglobin levels were been measured preoperative and 12 hrs. Postoperatively, blood loss volume was calculated by measuring both the weight of used materials before and after the surgery and the volume sucked in the suction bottle after placental delivery. Postoperative visual pain score and analgesic requirements were used to evaluate pain levels. Results. Analyzed collected data showed a significant decrease in blood loss in the melatonin group in comparison with the placebo group as measured by the hemoglobin level. On the other hand, there is a significant decrease in pain score and analgesia requirement with the melatonin group compared to the placebo group. Conclusion. Melatonin is a promising premedication drug that has a significant impact on postpartum hemorrhage by reducing blood loss and pain levels of mothers who have undergone C-sections.

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Section: Discussionmentioning

confidence: 99%

Impact of Melatonin as a Premedication Agent in Caesarean Section on Blood Loss and Postoperative Pain Level

Alkhfaji,

Kahloul,

Askar

et al. 2023

Anesthesiology Research and Practice

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Melatonin’s Impact on Wound Healing

Sohn,

Kim,

Lee

2024

Antioxidants

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Melatonin (5-methoxy-N-acetyltryptamine) is an indoleamine compound that plays a critical role in the regulation of circadian rhythms. While melatonin is primarily synthesized from the amino acid tryptophan in the pineal gland of the brain, it can also be produced locally in various tissues, such as the skin and intestines. Melatonin’s effects in target tissues can be mediated through receptor-dependent mechanisms. Additionally, melatonin exerts various actions via receptor-independent pathways. In biological systems, melatonin and its endogenous metabolites often produce similar effects. While injuries are common in daily life, promoting optimal wound healing is essential for patient well-being and healthcare outcomes. Beyond regulating circadian rhythms as a neuroendocrine hormone, melatonin may enhance wound healing through (1) potent antioxidant properties, (2) anti-inflammatory actions, (3) infection control, (4) regulation of vascular reactivity and angiogenesis, (5) analgesic (pain-relieving) effects, and (6) anti-pruritic (anti-itch) effects. This review aims to provide a comprehensive overview of scientific studies that demonstrate melatonin’s potential roles in supporting effective wound healing.

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Comparative Analysis of Surgical Techniques for Wisdom Tooth Extraction

Pillai,

Ibrahim,

Malhotra

et al. 2024

Journal of Pharmacy and Bioallied Sciences

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Background: Wisdom tooth extraction often requires various surgical techniques due to differences in tooth position, root morphology, and patient characteristics. This research aims to compare traditional surgical extraction with minimally invasive techniques such as piezo surgery and laser-assisted extraction, as well as extraction with the aid of 3D imaging and navigation systems. Methods: Patients requiring wisdom tooth extraction were randomly assigned to one of the surgical technique groups. Preoperative imaging assessed tooth position and root morphology. Intraoperative variables and postoperative outcomes were recorded, including pain levels, swelling, and healing time. Patient-reported outcomes were assessed using standardized questionnaires. Results: Piezo surgery, 3D imaging, and navigation-guided extraction techniques demonstrated a shorter mean duration of surgery and lower incidence of intraoperative complications compared to traditional extraction and laser-assisted extraction. Postoperative outcomes were superior in the 3D imaging and navigation-guided extraction group, with lower pain scores, reduced swelling, and faster healing time. Conclusion: Advanced imaging-guided techniques, particularly 3D imaging and navigation-guided extraction, offer significant benefits for patients undergoing wisdom tooth extraction by improving surgical precision, minimizing complications, and enhancing postoperative outcomes. Incorporating these technologies into routine practice can optimize patient care and outcomes in oral surgery.

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The Effect of Local Melatonin Application Following the Removal of an Impacted Mandibular Third Molar

Cited by 3 publications

References 38 publications

Impact of Melatonin as a Premedication Agent in Caesarean Section on Blood Loss and Postoperative Pain Level

Impact of Melatonin as a Premedication Agent in Caesarean Section on Blood Loss and Postoperative Pain Level

Melatonin’s Impact on Wound Healing

Comparative Analysis of Surgical Techniques for Wisdom Tooth Extraction

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