The effect of long term under- and over-feeding on the expression of genes related to lipid metabolism in the mammary tissue of goats

Tsiplakou, Eleni; Flemetakis, Emmanouil; Kouri, Evangelia D.; Zervas, G.

doi:10.1016/j.livsci.2014.12.010

Cited by 2 publications

(1 citation statement)

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“…This treatment caused a drop in milk production and component secretion in goats [ 157 , 169 , 170 ]. A significant reduction in the mRNA levels of ACACA , FASN , LPL , and SCD1 was also observed in the MG of underfed dairy goats compared with the respective overfed goats [ 171 ]. These data, in the bovine, the ovine, and the caprine MG, suggest a regulation of these genes at a transcriptional level by nutrition and indicate that the decrease in nutrient availability may lead to a lower rate of lipid synthesis.…”

Section: Effects Of Feed Restriction and Deprivation On Ruminant Mammary Gene Expressionmentioning

confidence: 99%

Nutritional Regulation of Mammary Gland Development and Milk Synthesis in Animal Models and Dairy Species

Hue-Beauvais

Faulconnier

Charlier

et al. 2021

Genes

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In mammals, milk is essential for the growth, development, and health. Milk quantity and quality are dependent on mammary development, strongly influenced by nutrition. This review provides an overview of the data on nutritional regulations of mammary development and gene expression involved in milk component synthesis. Mammary development is described related to rodents, rabbits, and pigs, common models in mammary biology. Molecular mechanisms of the nutritional regulation of milk synthesis are reported in ruminants regarding the importance of ruminant milk in human health. The effects of dietary quantitative and qualitative alterations are described considering the dietary composition and in regard to the periods of nutritional susceptibly. During lactation, the effects of lipid supplementation and feed restriction or deprivation are discussed regarding gene expression involved in milk biosynthesis, in ruminants. Moreover, nutrigenomic studies underline the role of the mammary structure and the potential influence of microRNAs. Knowledge from three lactating and three dairy livestock species contribute to understanding the variety of phenotypes reported in this review and highlight (1) the importance of critical physiological stages, such as puberty gestation and early lactation and (2) the relative importance of the various nutrients besides the total energetic value and their interaction.

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