The effect of long-term diabetes mellitus induced by treatment with streptozotocin in 6-week-old rats on functional activity of the adenylyl cyclase system

Ao, Shpakov; Derkach, K. V.; Chistyakova, O. V.; Moyseyuk, I. V.; Бондарева, В. М.

doi:10.1134/s1990519x14010118

Cited by 3 publications

(5 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The treatment of rats with low-dose STZ induced the model of mild DM1. Characteristics of this model include moderate insulin deficiency and hyperglycemia [16,17], and rats with long-term mild DM1 had a less evident decrease in thyroid hormones levels and unchanged or elevated level of TSH, which is often observed in autoimmune thyroiditis combined with DM1 in humans [15,18]. The duration of mild DM1 in rats is at least 4-5 months, which is quite enough to study progressively developing changes of HPT axis.…”

mentioning

confidence: 99%

The Influence of Intranasal Insulin on Hypothalamic-Pituitary-Thyroid Axis in Normal and Diabetic Rats

et al. 2015

View full text Add to dashboard Cite

The functions of hypothalamic-pituitary-thyroid axis are attenuated in type 1 diabetes mellitus due to insulin deficiency. The use of intranasally administered insulin is of considerable interest for treatment of diabetes and cognitive disorders, but its effect on the thyroid system has not been investigated yet. We studied the influence of long-term treatment with intranasal insulin on the hypothalamic-pituitary-thyroid axis of nondiabetic rats and diabetic animals with streptozotocin models of acute and mild type 1 diabetes mellitus. This treatment was carried out for 28 days in acute (daily does of 0.3, 0.6, and 1.5?IU of insulin per rat) and for 135 days in mild diabetes (daily dose of 0.45?IU/rat). Nondiabetic rats were treated in a similar manner. Intranasal insulin in both models of diabetes resulted in the improvement of thyroid status; manifested as increase of thyroid hormones levels and restoration of response to thyroliberin. In acute diabetes, a daily dose of 0.6?IU/rat was the most effective. Twenty eight days treatment of nondiabetic rats with intranasal insulin at a dose of 0.3?IU/rat resulted in a significant increase of free and total thyroxine levels. Longer treatment of rats with mild diabetes and nondiabetic animals significantly increased thyrotropin level. Thus, long-term intranasal insulin treatment restored the hypothalamic-pituitary-thyroid axis function in type 1 diabetes, but led to a significant increase in the thyrotropin level, which must be considered when designing a strategy for the use of intranasal insulin in clinical applications.

show abstract

mentioning

confidence: 99%

The Influence of Intranasal Insulin on Hypothalamic-Pituitary-Thyroid Axis in Normal and Diabetic Rats

et al. 2015

View full text Add to dashboard Cite

show abstract

“…The study of genotype of patients with DM2 and metabolic syndrome allowed detecting the mutation in a codon 64 of β 3 -AR gene, which led to a significant increase of activity of mutant receptor [47]. We also showed significant changes in the β 1 / β 2 /β 3 ratio in the myocardium of rats with different models of diabetic pathology, and the ratio was restored when the animals were treated with intranasal insulin and, in the case of DM2, with D 2 -agonist BC and metformin [13,20,28,44]. The increase of β 3 -AR activity prevents AC hyperactivation caused by the increased catecholamine levels characteristic for diabetic cardiomyopathy.…”

Section: The Acss In the Diabetic Heartmentioning

confidence: 75%

“…was initiated [44,50]. Our results indicate that changes in adrenergic signaling cascades in the heart are highly dependent on the experimental model of DM1.…”

Section: The Acss In the Diabetic Heartmentioning

confidence: 79%

“…The DM1 and DM2 are closely associated with severe cardiovascular diseases, such as acute myocardial infarction, congestive heart failure, and atherosclerosis [39,40]. The pathological changes in contractile function of the heart in DM are largely due to impairment of the adrenergic, cholinergic, and purinergic pathways of AC regulation in cardiomyocytes [28,39,[41][42][43][44]. The adrenergic signaling has a very important role in the functioning of the cardiovascular system, and it changes to the greatest extent in DM.…”

Section: The Acss In the Diabetic Heartmentioning

confidence: 99%

“…Unlike DM1, in DM2, the number of β-ARs in the myocardium is not substantially different from control, but the sensitivity of β-ARs to agonists and their effects on AC are decreased significantly [11,13,[51][52][53]. The changes in β-AR signaling strongly vary in rats with different models of DM2 depending on duration and severity of the disease [11,44,49,53,54]. In the myocardium of rats with 8-month neonatal model of DM2, the effect of isoproterenol on AC activity was increased, although to a small extent.…”

Section: The Acss In the Diabetic Heartmentioning

confidence: 99%

See 2 more Smart Citations

The Contribution of Changes in Adenylyl Cyclase Signaling System of the Brain and Myocardium to Etiology and Pathogenesis of Diabetes Mellitus

Шпаков¹

2018

Evolutionary Physiology and Biochemistry - Advances and Perspectives

View full text Add to dashboard Cite

The functional changes in hormone-sensitive adenylyl cyclase (AC) signaling system of the central nervous system (CNS) and periphery play a crucial role in etiology and pathogenesis of diabetes mellitus (DM). The identification of these changes in AC signaling system and the abnormalities in AC signaling network are necessary for creation of the new strategies to treat and prevent diabetic pathology. In this chapter, our data and the results of other authors on the changes in hormone-sensitive adenylyl cyclase signaling system (ACSS) in the diabetic brain and heart and on their contribution to etiology and pathogenesis of DM and its complications, diabetic cardiomyopathy in particular, are presented and analyzed, and the promising approaches to treat DM and its complications, which are based on the restoration of AC signaling cascades and their functional interaction, are discussed.

show abstract

The effect of 2-month bromocriptine treatment on the activity of the adenylyl cyclase signaling system in the myocardium and testes of rats with type 2 diabetes

et al. 2015

View full text Add to dashboard Cite

The effect of long-term diabetes mellitus induced by treatment with streptozotocin in 6-week-old rats on functional activity of the adenylyl cyclase system

Cited by 3 publications

References 46 publications

The Influence of Intranasal Insulin on Hypothalamic-Pituitary-Thyroid Axis in Normal and Diabetic Rats

The Influence of Intranasal Insulin on Hypothalamic-Pituitary-Thyroid Axis in Normal and Diabetic Rats

The Contribution of Changes in Adenylyl Cyclase Signaling System of the Brain and Myocardium to Etiology and Pathogenesis of Diabetes Mellitus

The effect of 2-month bromocriptine treatment on the activity of the adenylyl cyclase signaling system in the myocardium and testes of rats with type 2 diabetes

Contact Info

Product

Resources

About