The Effect of Low Dose Nylestriol–Levonorgestrel Replacement Therapy on Bone Mineral Density in Women with Postmenopausal Osteoporosis

Liao, Er-Yuan; Luo, Xi; Deng, Xiaoge; Wu, Xuesong; Liao, Huijuan; Pingfang, Wang; Mao, Jiping; Zhu, Xiaoying; Huang, Gan; Wei, Qi-you

doi:10.1081/erc-120022314

Cited by 10 publications

(9 citation statements)

References 8 publications

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“…14 Nylestriol, a derivative of long-acting estriol and a kind of lente estrogen, was synthesized in China in 1984. 15 The estrogenic activity of nylestriol is 3 times that of quinestrol, 23 times that of estriol, and 510 times that of estriol when orally administered. 15 Nylestriol with adequate calcium and vitamin D intake could increase BMD at the lumbar spine, neck, and hip and decrease bone turnover markers in postmenopausal women.…”

Section: Introductionmentioning

confidence: 99%

“…15 The estrogenic activity of nylestriol is 3 times that of quinestrol, 23 times that of estriol, and 510 times that of estriol when orally administered. 15 Nylestriol with adequate calcium and vitamin D intake could increase BMD at the lumbar spine, neck, and hip and decrease bone turnover markers in postmenopausal women. 16 To the best of authors' knowledge, there have been no previous studies on the protective effect of the combination of simvastatin and nylestriol.…”

Section: Introductionmentioning

confidence: 99%

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Effects of Simvastatin and Combination of Simvastatin and Nylestriol on Bone Metabolism in Ovariectomized Rats

Li¹,

Lin²,

Xie³

et al. 2016

American Journal of Therapeutics

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We aim to compare the effects of simvastatin and combination of simvastatin and nylestriol on bone metabolism in ovariectomized (OVX) rats. Fifty healthy Wistar female rats were randomly allocated into 5 groups: sham + saline group (group A), OVX + saline group (group B), OVX + simvastatin (5 mg·kg·d) (group C), OVX + nylestriol (0.01 mg·kg·d) (group D), and OVX + simvastatin (3 mg·kg·d) + nylestriol (0.005 mg·kg·d) (group E). All mice were orally administrated with saline or medicine dissolved in saline for 10 weeks. Body weight of rats before and after the experiment was measured. Twenty-four hours after the experiment, calcium (Ca), creatinine (Cr), and hydroxyproline in urine were detected. Serum levels of osteocalcin (bone Gla-protein, BGP) and alkaline phosphatase (ALP) were measured. Bone mineral density was detected and trabecular bone was observed after the isolation of femur and tibia. Remarkably decreased serum BGP and increased serum ALP levels were detected in group B compared with those in group A. However, notably increased serum BGP and decreased serum ALP levels were found in groups C, D, and E compared with those in group B; femoral and tibial bone mineral density decreased in group B compared with that in group A, but increased in groups C, D, and E compared with that in group B. Simvastatin and combination of simvastatin and nylestriol promote formation of new bone, increase bone density, and improve bone microstructure damage in OVX rats.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effects of Simvastatin and Combination of Simvastatin and Nylestriol on Bone Metabolism in Ovariectomized Rats

Li¹,

Lin²,

Xie³

et al. 2016

American Journal of Therapeutics

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“…As an estrogen derivative, estriol has been showed to prevent postmenopausal bone loss (3,4). Recently our studies showed that administration of nylestriol can prevent bone loss in osteoporotic rats or postmenopausal women (5,6). Recently our studies showed that administration of nylestriol can prevent bone loss in osteoporotic rats or postmenopausal women (5,6).…”

Section: Introductionmentioning

confidence: 99%

Effects of Estriol on the Proliferation and Differentiation of Human Osteoblastic MG‐63 Cells

Luo¹,

Liao²

2003

Endocrine Research

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Estriol has been showed to prevent bone loss in osteoporotic rats and postmenopausal women, but the mechanisms remain unclear. In the present study, we evaluated the effect of estriol on osteoblastic MG-63 cells in vitro, and compared its action with 17beta-estradiol (E2). Cell proliferation was determined by measuring total cell numbers and [3H]thymidine incorporation. Cell function was studied by measuring alkaline phosphatase (ALP) activity and secreted osteocalcin. Our data showed that estriol stimulated MG-63 cells proliferation in a dose-dependent manner, but had no influence on ALP activity in MG-63 cells and osteocalcin production. Compared with estriol treatment, E2 showed a stronger proliferation. Estrogen receptor (ER) alpha and beta expression in MG-63 cells can be detected by Western immunoblot analysis, and the proliferative response to E2 and estriol can be all abrogated by ER antagonist ICI 182,780. In conclusion, estriol stimulates osteoblastic MG-63 cells proliferation, but has no effects on differentiation. The proliferative response to estriol is mediated by the ER. These results suggest that estriol has an effect on osteoblastic proliferation, and this may contribute to its actions on prevention of bone loss.

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“…They found that bone loss was significantly prevented in total forearm in women with active treatment compared with control subjects. BMD at the lumbar spine tended to improve 61 . There was no side-effects observed on the breast by low-dose nylestriol treatment in the women 59,61 .…”

Section: Effects Of Low-dose Nylestriol In Postmenopausal Womenmentioning

confidence: 91%

“…BMD at the lumbar spine tended to improve 61 . There was no side-effects observed on the breast by low-dose nylestriol treatment in the women 59,61 .…”

Section: Effects Of Low-dose Nylestriol In Postmenopausal Womenmentioning

confidence: 91%

Low-dose hormone therapy in postmenopausal women in China

Hong

Speroff

2009

Climacteric

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The Effect of Low Dose Nylestriol–Levonorgestrel Replacement Therapy on Bone Mineral Density in Women with Postmenopausal Osteoporosis

Abstract: These data suggested that CNT is effective, safe and convenient in treating postmenopausal osteoporosis.

Cited by 10 publications

References 8 publications

Effects of Simvastatin and Combination of Simvastatin and Nylestriol on Bone Metabolism in Ovariectomized Rats

Effects of Simvastatin and Combination of Simvastatin and Nylestriol on Bone Metabolism in Ovariectomized Rats

Effects of Estriol on the Proliferation and Differentiation of Human Osteoblastic MG‐63 Cells

Low-dose hormone therapy in postmenopausal women in China

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