The effect of metal clips on the tensile properties of healing skin wounds

Abstract

The effects of nylon sutures and metal skin clips on the tensile properties of healing skin wounds have been studied in the pig. Wounds closed with clips have significantly poorer mechanical properties at 5, 7 and 14 days after wounding than similar wounds in the same animal closed with interrupted nylon sutures. This difference increased progressively with the period of retention of the clips. It is also shown that in equivalent groups of 14-day wounds, those in which clips were retained after the seventh day had a lower tensile strength, poorer ability to absorb energy and a lower elastic modulus than similar wounds where clips had been removed early. No such adverse effect was noted with nylon sutures.

Effect of CD4+ and CD8+ cell depletion on wound healing

“…The point of rupture of the specimen was noted carefully to ensure this conformed to the site of the wound. The complexity of wound biomechanics means that description based on only one parameter may be misleading 18 . Quantitative properties can be calculated from the load versus extension curve (Fig.…”

Inhibition of Nuclear Factor-κB and p38 Mitogen-Activated Protein Kinase Does Not Always Have Adverse Effects on Wound Healing

“…It also is interesting that incision breaking strengths were less on day seven than on day three for all groups. This may be explained in terms of the complexity of wound biomechanics [24,25]. Early healing is characterized by the deposition of a ''fibrin glue,'' the elastic component of which would result in a greater force being required per unit extension for incisions analyzed at an earlier time.…”

Tissue Adhesives and Alternative Wound Closure

“…26 Studies in animals have suggested, however, that wound tensile strength is actually greater for staples compared with sutures. Despite the remarkable amount of time saved by placing staples instead of sutures, early an imal and clinical investigations included questions about the capacity of staples to appose wound edges as accurately or to promote wound tensile strength as effectively as sutures.…”