The Effect of Methylene Blue on the Hemodynamic Changes During Ischemia Reperfusion Injury in Orthotopic Liver Transplantation

Koelzow, Heike; Gedney, Jacqueline A.; Baumann, János; Snook, Nicola J.; Bellamy, Mark

doi:10.1097/00000539-200204000-00009

Cited by 95 publications

(69 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These cascades of events may start after the advent of tissue damage-here due to impediment to the vascular tree-even if followed by volume or pressure resuscitation, as demonstrated herein. Support for this contention can be obtained from cases of limb ischemia [38] and its reperfusion [29], aortic cross-clamping and aneurysmectomy [19,24,29,30,34,38], and other traumatic or ischemic events in humans [39,40], as well as during organ transplant [41] and renal decompensation [42]. Importantly, the linear magnitude of changes of XO and GSH also attest to the role of the pressure in generating stress injury in the various kidneys.…”

Section: Discussionmentioning

confidence: 99%

Renal oxidative stress following CO2 pneumoperitoneum-like conditions

et al. 2008

View full text Add to dashboard Cite

Background Physiologic renal changes associated with pneumoperitoneum (PNP) have been described and various underlying mechanisms have been suggested. We investigated the possibility that PNP-associated renal damage is pressure dependent, and that oxidative stress is thereby involved. Materials and methods Seventy Wistar rat kidneys (n = 10 per group) were isolated. They were perfused with oxygenated, warm, Krebs-Henseleit solution containing 5% albumin within an isolated environment and subjected to various CO 2 pressures (0 [control], 3,5,8,12,15, and 18 mmHg) for 60 min. Half of each group was additionally perfused for 30 min at 0 mmHg pressure.Results Renal flow decreased proportionately to the applied pressure as did urine output: both decreased (P \ 0.05) after 60 and 90 min when pressure C8 mmHg was applied. Oxygen extraction decreased (P \ 0.05) during PNP in all pressurized groups. Xanthine oxidase (XO) activity and reduced glutathione in the tissues increased (P \ 0.05) proportionately to pressures C8 mmHg. All parameters slightly reversed toward baseline values, upon the release of the intra-chamber pressure, except for the 18 mmHg group's values. Conclusions CO 2 -PNP pressure induces kidney injury, possibly reversible immediately after pressure is annulled. Pressure is associated with oxidative stress, which interferes with cellular metabolism and function, possibly via an ischemic-reperfusion-like mechanism.

show abstract

Section: Discussionmentioning

confidence: 99%

Renal oxidative stress following CO2 pneumoperitoneum-like conditions

et al. 2008

View full text Add to dashboard Cite

show abstract

“…Preoperative treatment with antioxidants, as currently applied during liver transplant or heart surgery [39,40], could decrease renal tissue damage and enhance kidney recovery period. Such clinical studies will shed more light on the issue of antioxidant PNP renal function and recovery, and promote its amelioration.…”

Section: Discussionmentioning

confidence: 99%

Oxidants as important determinants of renal apoptosis during pneumoperitoneum: a study in an isolated perfused rat kidney model

Khoury

Weinbroum

2011

Surg Endosc

View full text Add to dashboard Cite

show abstract

“…In various experimental studies, MB's antioxidant, antiinflammatory and nitric oxide (NO)-blocking effects have been demonstrated [10][11][12] . MB has also been shown to protect organs like lung, liver and the intestines from I/R injury [13,14] .…”

Section: Introductionmentioning

confidence: 99%

Methylene Blue Decreases Ischemia-Reperfusion (I/R)-Induced Spinal Cord Injury: An in vivo Study in an I/R Rabbit Model

Bardakçi¹,

Kaplan²,

Karadeniz³

et al. 2006

Eur Surg Res

View full text Add to dashboard Cite

Objectives: To evaluate the effects of intravenous methylene blue (MB) administration on ischemia-reperfusion (I/R) injury of the spinal cord (SC). Methods: 16 rabbits were randomly assigned either to group M (n = 8; receiving MB, intervention group) or group C (n = 8; control group) and underwent a 30-min period of SC ischemia by clamping the abdominal aorta between the left renal artery and the aortic bifurcation. 15 min before clamping, rabbits received either intravenous MB (10 mg/kg; group M) or normal saline (group C). The two groups were compared 24 h postoperatively both histologically and for neurological function, using a Tarlov score. Measurements to determine levels of malondialdehyde (MDA) and glutathione (GSH) in the SC tissue were also performed. Results: Neurological impairment and spinal tissue MDA levels were significantly lower in animals treated with MB (p < 0.001). In contrast, spinal GSH levels were significantly higher in group M (p < 0.001). Histological examination revealed that the integrity of the SC was better preserved in the MB group, whereas cords from the control group exhibited evidence of acute neuronal injury. Conclusions: The prophylactic use of MB reduces neurological injury and improves clinical outcomes in the rabbit SC I/R model. These effects are probably mediated by the drug’s antioxidant properties.

show abstract

The Effect of Methylene Blue on the Hemodynamic Changes During Ischemia Reperfusion Injury in Orthotopic Liver Transplantation

Abstract: Methylene blue attenuates the hemodynamic changes of the ischemia reperfusion syndrome in liver transplantation, and this effect involves guanylate cyclase inhibition.

Cited by 95 publications

References 19 publications

Renal oxidative stress following CO2 pneumoperitoneum-like conditions

Renal oxidative stress following CO2 pneumoperitoneum-like conditions

Oxidants as important determinants of renal apoptosis during pneumoperitoneum: a study in an isolated perfused rat kidney model

Methylene Blue Decreases Ischemia-Reperfusion (I/R)-Induced Spinal Cord Injury: An in vivo Study in an I/R Rabbit Model

Contact Info

Product

Resources

About